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  • 1
    Electronic Resource
    Electronic Resource
    A · T → C · G transversions and their prevention by the Escherichia coli mutT and mutHLS pathways (1989)
    Springer
    Molecular genetics and genomics 219 (1989), S. 256-262 
    Details
    ISSN: 1617-4623
    Keywords: mutT mutator ; A · T → C · G transversions ; A · G mispairs ; Mismatch correction ; trpA system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Escherichia coli mutT strains are strong mutators yielding only A · T → C · G transversion mutations. These are thought to result from uncorrected (or unprevented) A · G mispairings during DNA replication. We have investigated the interaction of mutT-induced replication errors with the mutHLS-encoded postreplicative mismatch repair system. By measuring mutation frequencies in both forward and reversion systems, we have demonstrated that mutTmutL and mutTmutS double mutators produce no more mutants than expected from simple additivity of the frequencies in the single mutators. We conclude that mutT-induced A · G replication errors are not recognized by the MutHLS system. On the other hand, direct measurements of mismatch repair by transfection of bacteriophage M13mp2 heteroduplex DNA as well as mutational data from strains other than mutT indicate that the MutHLS system can repair at least certain A · G mispairs. We suggest that A · G mispairs may exist in several different conformations, some of which are recognized by the MutHLS system. However, the A · G mispairs normally prevented by the mutT function are refractory to mismatch repair, indicating that they may represent a structurally distinct class.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261185
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  • 2
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    The immunoglobulin octanucleotide: independent activity and selective interaction with enhancers (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-03-20
    Description: The thymidine kinase (tk) promoter of herpes simplex virus includes an octanucleotide sequence motif (ATTTGCAT) that is also an essential component of immunoglobulin kappa gene promoters. In the absence of an enhancer, tk promoter derivatives that contain this element support a higher rate of transcription than those that lack it. The action of the kappa enhancer augments that of the octanucleotide in B lymphoid cells; when both elements are present, tk promoter activity is increased by more than an order of magnitude. In contrast, the presence of the octanucleotide in this promoter markedly reduces its response to a nonimmunoglobulin enhancer. These results suggest that the octanucleotide may mediate a selective interaction among promoters and enhancers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parslow, T G -- Jones, S D -- Bond, B -- Yamamoto, K R -- AI22536/AI/NIAID NIH HHS/ -- CA20535/CA/NCI NIH HHS/ -- CM07810/CM/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Mar 20;235(4795):1498-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3029871" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Viral/genetics ; *Enhancer Elements, Genetic ; *Gene Expression Regulation ; *Genes, Regulator ; Immunoglobulin kappa-Chains/*genetics ; Lymphocytes/physiology ; Moloney murine sarcoma virus/genetics ; *Promoter Regions, Genetic ; Simplexvirus/genetics ; Thymidine Kinase/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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