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  • LUNAR AND PLANETARY EXPLORATION  (567)
  • Cell & Developmental Biology  (496)
  • 1985-1989  (1,021)
  • 1955-1959  (37)
  • 1925-1929  (5)
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  • 1
    ISSN: 0730-2312
    Keywords: elastase inhibitors ; β-lactams ; lung damage ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Human polymorphonuclear leukocyte elastase (PMN elastase) is inhibited by L-659, 286 (7α-methoxy-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triaz-in-3-yl)thio]methyl]-5-thia-1-aza-6R-bicyclo [4.2.O]oct-2-ene-2-pyrrolidine carboxamide-5,-dioxide) with a Ki of 0.4 μM. This inhibition is time-dependent, rapid, and only slowly reversible, with a t1/2 of 〉 3 days at 25°C. L-659, 286 is also highly selective for PMN elastase, as it does not inhibit thrombin, trypsin, papain, plasmin, chymotrypsin, or cathepsin G. L-659, 286 administered intratracheally inhibits lung damage caused by administration via the same route of human PMN elastase into hamsters. In marmosets, L-659, 286 is cleared from blood very rapidly after an intravenous injection but is recovered in bronchoalveolar lavage fluid for several hours after intratracheal administration.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2011-08-19
    Description: Saturn was observed in the vicinity of the J = 10 manifold of the pure rotational band of phosphine on 1984 July 10 and 12 from NASA's Kuiper Airborne Observatory with the facility far-infrared cooled grating spectrometer. On each night observations of the full disk plus rings were made at 4 to 6 discrete wavelengths which selectively sampled the manifold and the adjacent continuum. The previously reported detection of this manifold is confirmed. After subtraction of the flux due to the rings, the data are compared with disk-averaged models of Saturn. It is found that PH3 must be strongly depleted above the thermal inversion (approx. 70 mbar). The best fitting models consistent with other observational constraints indicate that PH3 is significantly depleted at even deeper atmospheric levels (or = 500 mbar), implying an eddy diffusion coefficient for Saturn of 10 to the 4 cm sq/sec.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Icarus (ISSN 0019-1035); 64; 549-556
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  • 3
    Publication Date: 2011-08-19
    Description: The results of preliminary analyses of radio occultation data obtained by Voyager 2 as it passed Uranus are described. The occultations took place between 2-7 deg S latitude and yielded atmospheric temperature profiles between pressure levels of 10-900 mbar, an altitude range of 100 km. The mole fractions of hydrogen and helium in the tropopause were estimated, in conjunction with IR data, to about 0.85 and 0.10-0.20, respectively. Radio signal intensity data indicated the presence of a cloud deck of CH4 ice at a pressure level of 1300 mbar and a temperature of 81 K, implying a CH4 mole fraction of 0.02 at very low altitudes. The ionosphere extended upward, in two levels, to more than 10,000 km altitude. The ring system was different than the one around Saturn and possessed cylindrical substructures. The radio data also permitted mass density estimates for the five major moons, i.e., about 1.40 gr/cu cm, a value which rules out cometary origins.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Science (ISSN 0036-8075); 233; 79-84
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  • 4
    Publication Date: 2011-08-19
    Description: The Apollo 16 regolith breccias were characterized in terms of petrography, grain-size distribution, porosity, major and trace element composition, noble gas contents, and ferromagnetic resonance properties. Significant variation was found with respect to density and porosity; the more dense breccias displayed substantial shock damage. The breccias resembled the soils in grain-size distribution and in petrological components, though many were found to be compositionally different from the Apollo 16 soils in that a mafic component was lacking. Nearly all breccias showed evidence of irradiation at the lunar surface, and analyses of disaggregated breccias indicated that this irradiation occurred before compaction. The concentration of surface irradiation parameters were far less than those of lunar soils or breccias of other Apollo missions. Observations with respect to the argon isotope ratio and Xe presence have led to the possibility that breccia-surface irradiation occurred as early as four billion years ago, and that most Apollo 16 regolith breccias were not formed from any known Apollo 16 soil.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); 91; D277-D30
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  • 5
    Publication Date: 2011-08-19
    Description: A total of 28 Apollo 15 regolith breccias were analyzed for their petrographic and textural properties and for the surface exposure indices solar noble gases and I (sub s)/Fe 0. Similarities and differences in compositional components and irradiation history were examined between regolith breccias and local, present day soils.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Lunar and Planetary Inst. Papers Presented to the Workshop on tyhe Geology and Petrology of the Apollo 15 Landing Site; p 7-9
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  • 6
    Publication Date: 2019-07-12
    Description: Observations of electrostatic waves in the magnetosphere of Uranus are discussed with attention focused on the Bernstein emissions. The most intense Bernstein waves were observed near the magnetic equator of the planet, even though the tilt of the Uranian magnetic moment is very large relative to the rotational axis. In addition to the Bernstein modes, a number of highly sporadic emissions were detected in the vicinity of the Miranda L shell.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); 92; 15225-15
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  • 7
    Publication Date: 2019-07-13
    Description: The characteristics of 28 regolith breccias returned from the Apollo 15 site have been compared with those of Apollo 15 soils, Apollo 15 rock types, and Apollo 16 regolith breccias. The results suggest that KREEP basalts are not exotic to the site, and that the site is underlain by KREEP basalts which were converted to a KREEP-rich regolith full of small KREEP basalt fragments and KREEP composition glass. A possible implication of the present model is that agglutinate production was not significant in the time interval from 3.9-3.3 Gy.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Lunar and Planetary Science Conference; Mar 14, 1988 - Mar 18, 1988; Houston, TX; United States
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  • 8
    Publication Date: 2019-08-27
    Description: X-rays are produced in auroral discharges, and their measurement can serve to characterize the interaction processes responsible for the aurora itself. The existence of auroral activity on Saturn was suggested by the observation of a magnetosphere by Pioneer 11 and confirmed by UV measurements during the Voyager encounters. The detection of X-rays from Jupiter with the Einstein Observatory (HEAO 2) satellite provided the impetus for a subsequent observation of Saturn. No emission was detected. This article presents the upper limit established by the observation and derives an expected emission level assuming X-ray production to be the result of bremsstrahlung from keV electrons precipitating into Saturn's atmosphere. The difference is a factor of 100.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 300; 453-455
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal of Morphology 191 (1987), S. 77-87 
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Development and innervation of the lymph heart musculature of chicken, emu, rhea, and duck was studied by electron microscopy at posthatch ages from 3 days to adulthood. Development of innervation was monitored by acetylcholinesterase staining. Horseradish peroxidase was used to determine the extent of the transverse tubule network. Chickens were unusual among these birds in that lymph heart myocytes had already undergone a definitive differentiation and degeneration by 3 days. In ducks and ratite birds, lymph heart myocytes more slowly but progressively differentiate a cytomorphology that does not conform in all characteristics to cardiac or skeletal muscle and even resembles in some aspects, smooth muscle. Myofibrils become the dominant cytoplasmic structure, transverse tubules form ‘internal couplings’ with agranular reticulum cisternae, and ‘external couplings’ are formed between myocytes at myomyal junctions. The myomyal junctions also contain AChE-positive reaction product and some subplasmalemmal vesicles that lack a dense core. The lymph heart myocardium of ducks of 2 weeks demonstrated mitotic figures. In adult ducks the myosatellite cell numbers diminish and a characteristic pattern of myocyte degeneration appears. In juvenile ducks and ratites some myocytes differentiate to conductile cells, much as the conductile myocytes and myofibers of the blood heart. The lymph heart innervation is described, and the role of nerve in differentiation and maintenance of myocyte morphology in the lymph heart is discussed.
    Additional Material: 4 Ill.
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  • 10
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Conjugates of the single-chain ribosome-inactivating protein gelonin with ligands that bind to cell surface molecules vary greatly in their cytotoxicity. Conjugates that are not endocytosed after binding to cells exhibit low cytotoxicity similar to that of free gelonin, while conjugates that are endocytosed demonstrate enhanced cytotoxicity relative to free gelonin. However, the number of internalized gelonin molecules needed to intoxicate cells to the same degree has been found to be similar for all conjugates and for free gelonin. The intracellular concentration of gelonin has to be between 2,000-10,000 molecules/cell to achieve a surviving fraction of 0.37. Our studies revealed the presence of three distinct categories of cell surface molecules, those that are efficient in mediating endocytosis of im-munotoxins, those that are only moderately efficient, and those that seem not to cause internalization of bound immunotoxins.
    Additional Material: 4 Ill.
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