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  • AERODYNAMICS  (9)
  • GEOPHYSICS  (6)
  • pharmacokinetics  (3)
  • 1985-1989  (18)
  • 1955-1959
  • 1930-1934
  • 1
    Electronic Resource
    Electronic Resource
    The effect of cimetidine on the pharmacokinetics, pharmacodynamics and alpha1-adrenoceptor responsiveness of trimazosin in man (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 301-306 
    Details
    ISSN: 1432-1041
    Keywords: trimazosin ; cimetidine ; pharmacokinetics ; alpha-adrenoceptor antagonism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of cimetidine treatment on the pharmacokinetics and pharmacodynamics of single doses of trimazosin was studied in 6 normotensive volunteers. Co-administration of cimetidine did not significantly affect the overall magnitude of the hypotensive effect of trimazosin. However, the time profile of the blood pressure response was significantly modified particularly with attenuation of the delayed component. Co-administration of cimetidine did not alter alpha1-adrenoceptor antagonism by trimazosin. There was no significant change in the clearnace and volume of distribution of trimazosin but there was a significant reduction in the area under the concentration-time curve for the metabolite, 1-hydroxytrimazosin. The reduction in the AUC of 1-hydroxy-trimazosin corresponds in time with the attenuation of the delayed hypotensive response. This is consistent with the suggestion that the delayed hypotensive response is related to an active metabolite, probably 1-hydroxytrimazosin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544084
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Antisecretory effect and oral pharmacokinetics of omeprazole in patients with chronic renal failure (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 637-640 
    Details
    ISSN: 1432-1041
    Keywords: omeprazole ; renal failure ; gastric secretion ; pharmacokinetics ; haemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The inhibitory effect of omeprazole on gastric acid secretion was tested in a group of patients on haemodialysis for chronic renal failure. Single 30 mg doses almost totally inhibited basal acid output on both dialysis and non-dialysis days. Plateau acid output was reduced by a mean of 77% and 90% on non-dialysis and dialysis days respectively. The absorption and pharmacokinetic profile of omeprazole were not affected by dialysis. Omeprazole was not recoverable from dialysis fluid. It is concluded that omeprazole is a potent inhibitor of gastric acid secretion in patients with chronic renal failure, and its effect is not influenced by haemodialysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607907
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of low-dose dexamethasone in congenital adrenal hyperplasia (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 75-77 
    Details
    ISSN: 1432-1041
    Keywords: dexamethasone ; congenital adrenal hyperplasia ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of dexamethasone, given at low dose, were studied in 13 patients with congenital adrenal hyperplasia (CAH) to ascertain whether kinetics differed in this inherited disorder of cortisol metabolism from those seen in healthy individuals. Changes in plasma dexamethasone concentration after intravenous bolus, measured using a simple novel radioimmunoassay, were well described by a two-compartment open model with first-order kinetics. Values for λ2: 0.206 h−1, t1/2: 3.53 h, Vc: 24.41 and f: 0.64 were similar to those previously reported for normal subjects. There were considerable interindividual differences in parameter values and Cmaxp.o. (range 22–67 nmol/l). As suppression of the hypothalamo-pituitary-adrenal axis correlates with plasma dexamethasone levels, this variability may partly explain the differing dose and dose schedule requirements necessary to achieve adequate therapeutic control in the clinical management of CAH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609429
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  • 4
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    Enhancements of energetic ions associated with travelling compression regions in the deep geomagnetic tail (1987)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: This paper presents a representative example of an enhancement in energetic ion flux associated with the International Sun-Earth Explorer 3 (ISEE 3) spacecraft's encounter with a traveling compression region (TCR). Data from the energetic particle anisotropy spectrometer (EPAS) instrument on ISEE 3 are studied, along with magnetic field data from the vector helium magnetometer. It is concluded that the ion enhancements seen are spatial in nature, thus supporting the idea that TCRs are the lobe signatures of plasmoids moving along the magnetotail, away from earth.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 92; 64-70
    Format: text
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  • 5
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    Effects of thrust reversing in ground proximity (1987)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: The changes in stability and control characteristics encountered by a thrust reversing aircraft during its final approach, landing, and ground roll are described. These changes include a strong pitch-up accompanied by the loss of horizontal tail and aileron control effectiveness. The magnitude of reverser induced changes in ground effect are much larger than corresponding changes in free air. Some unexpected unsteady motions exhibited in wind tunnel by an aircraft model with reversers operating in ground proximity are also described. The cause of this oscillatory behavior was determined to be an unsteady interaction between the wall jets formed by impingement of reverser jets on the ground and the on-coming free stream. Time histories of rolling moments measured by the wind tunnel balance or support system were removed and frequencies were scaled by Strouhal number to full scale. Corrected time series were used to simulate the motion of a fighter aircraft with thrust reversers in ground effect. The simulation predicted large roll angles and nose down attitude at touchdown. Some phenomena of jet attachment to solid surfaces are discussed and areas for future research are recommended.
    Keywords: AERODYNAMICS
    Type: NASA. Ames Research Center Proceedings of the 1985 NASA Ames Research Center's Ground-Effects Workshop; p 239-288
    Format: application/pdf
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  • 6
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    A Petrov-Galerkin finite element method for the compressible Euler and Navier-Stokes equations (1986)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: An overview of a new finite element method for the compressible Euler and Navier-Stokes equations is presented. The discretization is based on entropy variables. The method is developed within the framework of a Petrov-Galerkin formulation. Two perturbations are added to the weighting function; one is a generalization of the SUPG operator and the other is designed to enhance shock capturing capability. The treatment of boundary conditions and the consistent calculation of boundary fluxes are addressed. Results of numerical tests are presented which confirm the robustness and wide applicability of the method.
    Keywords: AERODYNAMICS
    Format: text
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  • 7
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    CDAW 8 observations of plasmoid signatures in the geomagnetic tail - An assessment (1989)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Magnetotail observations from the ISEE 3 distant (1983) tail mission taken during the Coordinated Data Analysis Workshop 8 (CDAW 8) A and G events are investigated. The ISEE 3 magnetic field, plasma, and energetic particle measurements taken in these two plasmoids have been analyzed and compared with various equilibrium structures and propagating waves/tail oscillation modes. Results indicate general agreement with either the closed-loop (Hones, 1977) or very small pitch angle flux rope (Hughes and Sibeck, 1987; Birn et al., 1989) models of plasmoid structure and poorer agreement with other hypotheses. Calculations based upon typical plasmoid and tail parameters are presented, indicating that the J and B force associated with the disconnected lobe field lines may be sufficient to accelerate plasmoids up to the speeds observed by ISEE 3. Overall, the energy expended in accelerating the plasmoids down the tail appears comparable to that dissipated in the inner magnetosphere and ionosphere. The study produces strong evidence in favor of the plasmoid model of substorm tail dynamics.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research (ISSN 0148-0227); 94; 15153-15
    Format: text
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  • 8
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    Summary of low-speed wind tunnel results of several high-speed counterrotation propeller configurations (1988)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: The low speed aerodynamic performance characteristics of several advanced counterrotation pusher propeller configurations with cruise design Mach numbers of 0.72 and 0.80 were investigated in the NASA Low Speed Wind Tunnel. The tests were conducted at Mach numbers representative of the takeoff and landing flight regime. The investigation included: (1) the propeller performance characteristics over a range of blade angle settings and rotational speeds at a Mach number of 0.20; (2) the effect on the propeller performance of varying the axial rotor spacing and mismatching the power and rotational speeds on the propeller rotors; and (3) determining the reverse thrust performance characteristics at Mach numbers of 0.0, 0.10, 0.15 and 0.20. The results of the investigation indicated that the overall low speed performance of the counterrotation propeller configurations was reasonable.
    Keywords: AERODYNAMICS
    Type: AIAA PAPER 88-3149
    Format: text
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  • 9
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    Summary of low-speed wind tunnel results of several high-speed counterrotation propeller configurations (1988)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: The low speed aerodynamic performance characteristics of several advanced counterrotation pusher propeller configurations with cruise design Mach numbers of 0.72 and 0.80 were investigated in the NASA Low Speed Wind Tunnel. The tests were conducted at Mach numbers representative of the takeoff and landing flight regime. The investigation included: (1) the propeller performance characteristics over a range of blade angle settings and rotational speeds at a Mach number of 0.20; (2) the effect on the propeller performance of varying the axial rotor spacing and mismatching the power and rotational speeds on the propeller rotors; (3) determining the reverse thrust performance characteristics at Mach numbers of 0.0, 0.10, 0.15 and 0.20. The results of the investigation indicated that the overall low speed performance of the counterrotation propeller configurations was reasonable.
    Keywords: AERODYNAMICS
    Type: NASA-TM-100945 , E-4234 , NAS 1.15:100945 , AIAA PAPER 88-3149
    Format: application/pdf
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  • 10
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    Low-speed wind tunnel performance of high-speed counterrotation propellers at angle-of-attack (1989)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: The low-speed aerodynamic performance characteristics of two advanced counterrotation pusher-propeller configurations with cruise design Mach numbers of 0.72 were investigated in the NASA Lewis 9- by 15-Foot Low-Speed Wind Tunnel. The tests were conducted at Mach number 0.20, which is representative of the aircraft take/off/landing flight regime. The investigation determined the effect of nonuniform inflow on the propeller performance characteristics for several blade angle settings and a range of rotational speeds. The inflow was varied by yawing the propeller mode to angle-of-attack by as much as plus or minus 16 degrees and by installing on the counterrotation propeller test rig near the propeller rotors a model simulator of an aircraft engine support pylon and fuselage. The results of the investigation indicated that the low-speed performance of the counterrotation propeller configurations near the take-off target operating points were reasonable and were fairly insensitive to changes in model angle-of-attack without the aircraft pylon/fuselage simulators installed on the propeller test rig. When the aircraft pylon/fuselage simulators were installed, small changes in propeller performance were seen at zero angle-of-attack, but fairly large changes in total power coefficient and very large changes of aft-to-forward-rotor torque ratio were produced when the propeller model was taken to angle-of-attack. The propeller net efficiency, though, was fairly insensitive to any changes in the propeller flowfield conditions near the take-off target operating points.
    Keywords: AERODYNAMICS
    Type: AIAA PAPER 89-2583
    Format: text
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