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  • Cell & Developmental Biology  (523)
  • ASTRONOMY  (310)
  • 1985-1989  (764)
  • 1960-1964  (31)
  • 1950-1954  (38)
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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological profile of the substituted beta-lactam L-659,286: A member of a new class of human PMN elastase inhibitors (1989)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 39 (1989), S. 47-53 
    Details
    ISSN: 0730-2312
    Keywords: elastase inhibitors ; β-lactams ; lung damage ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Human polymorphonuclear leukocyte elastase (PMN elastase) is inhibited by L-659, 286 (7α-methoxy-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triaz-in-3-yl)thio]methyl]-5-thia-1-aza-6R-bicyclo [4.2.O]oct-2-ene-2-pyrrolidine carboxamide-5,-dioxide) with a Ki of 0.4 μM. This inhibition is time-dependent, rapid, and only slowly reversible, with a t1/2 of 〉 3 days at 25°C. L-659, 286 is also highly selective for PMN elastase, as it does not inhibit thrombin, trypsin, papain, plasmin, chymotrypsin, or cathepsin G. L-659, 286 administered intratracheally inhibits lung damage caused by administration via the same route of human PMN elastase into hamsters. In marmosets, L-659, 286 is cleared from blood very rapidly after an intravenous injection but is recovered in bronchoalveolar lavage fluid for several hours after intratracheal administration.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240390106
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  • 2
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    Observations of the J = 10 manifold of the pure rotational band of phosphine on Saturn (1986)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Saturn was observed in the vicinity of the J = 10 manifold of the pure rotational band of phosphine on 1984 July 10 and 12 from NASA's Kuiper Airborne Observatory with the facility far-infrared cooled grating spectrometer. On each night observations of the full disk plus rings were made at 4 to 6 discrete wavelengths which selectively sampled the manifold and the adjacent continuum. The previously reported detection of this manifold is confirmed. After subtraction of the flux due to the rings, the data are compared with disk-averaged models of Saturn. It is found that PH3 must be strongly depleted above the thermal inversion (approx. 70 mbar). The best fitting models consistent with other observational constaints indicate that PH3 is significantly depleted at even deeper atmospheric levels ( or = 500 mbar), implying an eddy diffusion coefficient for Saturn of 10 to the 4 cm sq/sec.
    Keywords: ASTRONOMY
    Type: NASA-TM-86851 , REPT-85434 , PREPRINT-SER-042 , NAS 1.15:86851
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Fast spectroscopic variations on rapidly-rotating, cool dwarfs. 3: Masses of circumstellar absorbing clouds on AB Doradus (1989)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: New time-resolved H alpha, Ca II H and K and Mg II h and k spectra of the rapidly-rotating K0 dwarf star AB Doradus (= HD 36705). The transient absorption features seen in the H alpha line are also present in the Ca II and Mg II resonance lines. New techniques are developed for measuring the average strength of the line absorption along lines of sight intersecting the cloud. These techniques also give a measure of the projected cloud area. The strength of the resonance line absorption provides useful new constraints on the column densities, projected surface areas, temperatures and internal turbulent velocity dispersions of the circumstellar clouds producing the absorption features. At any given time the star appears to be surrounded by at least 6 to 10 clouds with masses in the range 2 to 6 x 10(exp 17) g. The clouds appear to have turbulent internal velocity dispersions of order 3 to 20 km/s, comparable with the random velocities of discrete filamentary structures in solar quiescent prominences. Night-to-night changes in the amount of Ca II resonance line absorption can be explained by changes in the amplitude of turbulent motions in the clouds. The corresponding changes in the total energy of the internal motions are of order 10(exp 29) erg per cloud. Changes of this magnitude could easily be activated by the frequent energetic (approximately 10(exp 34) erg) x ray flares seen on this star.
    Keywords: ASTRONOMY
    Type: NASA-CR-186563 , NAS 1.26:186563
    Format: application/pdf
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  • 4
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    Research in planetary astronomy and operation of the 2.2-meter telescope (1986)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The turn-around in the secular change in brightness of Pluto was detected, the planet is now beginning to brighten. The spectral signature was found of an ammonia bearing compound in the surface ices of Europa. Specific Io volcanic hotspots were detected from infrared photometry of the mutual events of the Jovian satellites. The polarized emission from the volcanic hotspots on Io was discovered and the locations of those hotspots were determined. The orbit of Charon was refined from speckle observations of the Pluto-Charon system. The spectral properties of liquid nitrogen-methane mixtures with reference to the infrared spectrum of Triton were studied. Major progress was made in modeling asteroid lightcurves from a modern theory of photometric properties of the asteroid surfaces. Several additional olivine-rich asteroids from near-infrared spectrophotometry were discovered. Important photometric, spectroscopic, narrow-band imaging data on Comet P/Halley was acquired, along with Schmidt photographs of Comet P/Halley and its tail.
    Keywords: ASTRONOMY
    Type: NASA, Washington Reports of Planetary Astronomy, 1985; p 28-31
    Format: text
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  • 5
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    The project EGRET (Energetic Gamma-Ray Experiment Telescope) on NASA's Gamma-Ray Observatory (GRO) (1988)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: The design, predicted performance, and scientific objectives of the 20-30,000-MeV gamma-ray telescope EGRET for the NASA GRO spacecraft (scheduled for Space Shuttle launch to a 450-km 28.5-deg orbit in 1990) are reviewed. The other GRO instruments are briefly characterized, including the burst and transient-source experiment, the oriented scintillation spectrometer, and the imaging Compton telescope. EGRET comprises an anticoincidence system, a spark chamber, a triggering telescope, an NaI total-absorption spectrometer, a gas supply capable of refilling the chamber four times, and support electronics. EGRET will operate with energy resolution about 15 percent, effective area about 2000 sq cm, sensitivity about 5 x 10 to the -8th/sq cm sec, angular resolution 0.1-0.4 deg, and FOV about 40 deg FWHM. Observations of Galactic point sources, Galactic and extragalactic diffuse emission, gamma-ray bursts, and solar flares are planned.
    Keywords: ASTRONOMY
    Type: Space Science Reviews (ISSN 0038-6308); 49; 1-2,
    Format: text
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  • 6
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    A VLBI survey at 2.29 GHz (1985)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: VLBI observations at 2.29 GHz with fringe spacings of about 3 milliarcsec have been performed on 1398 radio sources spread over the entire sky. 917 sources were detected, including 93 percent of the identified BL Lacertae objects, 86 percent of the quasars, and 36 percent of the galaxies. The resulting catalog of compact radio sources is useful for various astrophysical studies and in the formation of VLBI celestial reference frames.
    Keywords: ASTRONOMY
    Type: Astronomical Journal (ISSN 0004-6256); 90; 1599-164
    Format: text
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  • 7
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    Arcsecond positions for milliarcsecond VLBI nuclei of extragalactic radio sources. III - 74 sources (1985)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: VLBI measurements at 2290 and 8420 MHz on baselines of 10,000 km have been used to determine the positions of the milliarcsecond nuclei in 74 extragalactic radio sources. Estimated accuracies range from 0.1 to 4.3 arcsec in both right ascension and declination with typical accuracies of about 0.3 arcsec. The observed sources are part of an all-sky VLBI catalog of milliarcsecond radio sources. Arcsecond positions have been determined for 819 sources. These positions are presently being used to identify optical counterparts in the southern hemisphere.
    Keywords: ASTRONOMY
    Type: Astronomical Journal (ISSN 0004-6256); 90; 590-594
    Format: text
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  • 8
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    Infrared Astronomical Satellite (IRAS) image reconstruction and restoration (1987)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: IRAS sky mapping data is being reconstructed as images, and an entropy-based restoration algorithm is being applied in an attempt to improve spatial resolution in extended sources. Reconstruction requires interpolation of non-uniformly sampled data. Restoration is accomplished with an iterative algorithm which begins with an inverse filter solution and iterates on it with a weighted entropy-based spectral subtraction.
    Keywords: ASTRONOMY
    Type: Advances in image processing; Mar 31, 1987 - Apr 03, 1987; The Hague; Netherlands
    Format: text
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  • 9
    Electronic Resource
    Electronic Resource
    Changes in visual fields associated with web reduction in the spider family uloboridae (1987)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 192 (1987), S. 87-100 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: When visual fields of the primitive orb-weaver, Waitkera waitkerensis, are reconstructed using measurements taken from intact lenses and cross and longitudinal sections of the prosoma, they show that this species has complete visual surveillance, but that none of the visual fields of its eight eyes overlap. The more advanced orb-weaver, Uloborus glomosus, also has eight eyes, but each eye has a greater visual angle, giving this species a complex pattern of overlapping visual fields. Uloborids that spin reduced webs are characterized by reduction or loss of the four anterior eyes and other carapace modifications necessary for them to effectively monitor and manipulate their reduced webs. The eyes of these uloborids have greater visual angles than those of orb-weavers, resulting primarily from perimetric expansion of their retinal hemispheres. Additionally, the axes of their visual fields are more ventrally directed due to greater dorsal than ventral retinal expansion and to ventral redirection of the entire eye. Consequently, even though the anterior lateral eyes of the triangle-weaver Hyptiotes cavatus lack retinae, the species' six functional eyes permit complete visual surveillance and exhibit visual overlap. The single-line-weaver, Miagrammopes animotus, has lost its four anterior eyes, and with them much of the anterior vision and all of the visual overlap found in the other species. However, changes similar to those of H. cavatus permit this species to retain most if its dorsal and ventral visual surveillance. Thus, ocular changes act in consort to maintain relatively complete visual surveillance in the face of eye loss and other major carapace modifications necessary for the operation of reduced webs.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051920202
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  • 10
    Electronic Resource
    Electronic Resource
    Transformation of mouse bone marrow cells by transfection with a human oncogene related to c-myc is associated with the endogenous production of macrophage colony stimulating factor 1 (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 125 (1985), S. 403-412 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: We recently derived a series of transformed cell lines by transfecting mouse bone marrow cells highly enriched for macrophage progenitors with a newly described human gene, R-myc, which has homology to the c-myc oncogene. In this report, we show that these lines share some features characteristic of cells of the mononuclear phagocyte lineage. Specifically, all cell lines had macrophage-or monocytelike morphology, contained nonspecific esterase, were phagocytic for latex beads, secreted lysozyme, bore the Mac-1 antigen, and contained a minority of cells with Fc receptors. However, only a single monocytelike clone had appreciable numbers of cells which bore complement receptor 1, and none were phagocytic for antibody or complementcoated particles, or constitutively secreted Interleukin-1. All these cell lines secreted a growth factor capable of supporting the in vitro proliferation of bone marrow macrophages. Radiommunoassay and receptor binding studies indicate that this factor is colony stimulating factor 1.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041250307
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