ISSN:
1435-604X
Keywords:
Tumour imaging
;
Tc-99m-HpD
;
Kinetics
;
Photodynamic therapy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Physics
,
Technology
Notes:
Abstract The in vivo uptake of Tc-99m-labelled HpD in a murine tumour has been investigated using nuclear imaging techniques. Eighty-four per cent of the palpable tumours were visualized with good contrast resolution. The peak tumour-to-surrounding-normal-tissue ratio of 5:1 was at 4 h post-injection indicating the optimum time of imaging. The high level of HpD in the blood-pool component of the tumour could indicate that photodynamic therapy administered within 2 h after intravenous injection (‘early PDT’) could lead to damage of tumour vasculature and tumour necrosis. The therapeutic response achieved by this early method needs to be investigated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02032449
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