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  • drug interaction  (21)
  • Best. von Kupfer(II) mit Succinimid
  • Bone
  • Collagen
  • Dehydration
  • transformation
  • Springer  (42)
  • American Physical Society
  • Annual Reviews
  • International Union of Crystallography
  • 1985-1989  (31)
  • 1965-1969  (9)
  • 1955-1959  (2)
  • 1945-1949
Collection
Keywords
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  • Springer  (42)
  • American Physical Society
  • Annual Reviews
  • International Union of Crystallography
  • Wiley-Blackwell  (1)
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    The pharmacodynamic and pharmacokinetic interaction of flecainide acetate with propranolol: Effects on cardiac function and drug clearance (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 97-99 
    Details
    ISSN: 1432-1041
    Keywords: flecainide ; propranolol ; pharmacodynamics ; pharmacokinetics ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00610389
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  • 2
    Electronic Resource
    Electronic Resource
    Evolution of chick type I procollagen genes (1985)
    Springer
    Journal of molecular evolution 22 (1985), S. 209-219 
    Details
    ISSN: 1432-1432
    Keywords: Collagen ; Ancestral genetic domain ; Simple sequence amplification ; Consensus sequence ; Introns
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Although the major types of vertebrate collagen have a number of structural properties in common, significant DNA sequence homologies have not been detected between different portions of the helical coding domains within the same gene or between different genes. However, under non-stringent hybridization conditions we found considerable cross-homology within and between α1(I) and α2(I) chick cDNAs in the coding regions for helical sequences. Detailed analyses at the DNA sequence level have led us to propose that the gene for chick pro α2(I) collagen arose from a 9-bp primordial sequence. A consensus sequence for the 9-bp repeat was derived: GGTCCTCCT, which codes for a Gly-Pro-Pro triplet. The primordial ancestor of this 9-bp unit, GGTCCTXCT, apparently underwent duplication and divergence. Each resulting 9-bp sequence was triplicated to form a 27-bp domain, and a condensation event produced a 54-bp domain. This genetic unit then underwent multiple rounds of amplification to form the ancestral gene for the full-length helical section of α2(I). A different 9-bp consensus sequence (GGTCCCCCC) seems to have been the basis of the chick pro α1(I) gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02099750
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  • 3
    Electronic Resource
    Electronic Resource
    Interaction study of fenoldopam — digoxin in congestive heart failure (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 395-397 
    Details
    ISSN: 1432-1041
    Keywords: fenoldopam ; digoxin ; drug interaction ; CHF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The potential interaction between fenoldopam, a DA1 selective agonist, and digoxin has been studied in 10 patients with heart failure (NYHA Class II or III) on chronic digoxin treatment. Plasma levels and urinary recovery of the glycoside were monitored for 24 h before and after 9 days of treatment with fenoldopam 100 mg tid. Fenoldopam caused a small, non-significant decrease in the mean steady state plasma concentration and area under the plasma concentration curve of digoxin. As the clearance of digoxin was unchanged there does not appear to be an interaction between fenoldopam and digoxin at the level of the renal tubule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558507
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  • 4
    Electronic Resource
    Electronic Resource
    Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol (1986)
    Springer
    European journal of clinical pharmacology 29 (1986), S. 717-719 
    Details
    ISSN: 1432-1041
    Keywords: sulphinpyrazone ; oxprenolol ; antihypertensive activity ; cyclo-oxygenase ; prostaglandins ; drug interaction ; drug metabolizing enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The interfering effect of sulphinpyrazone, a uricosuric agent which reduces the activity of cyclo-oxygenase, with the antihypertensive activity of oxprenolol, a non-cardioselective beta-blocker with sympathomimetic activity, has been evaluated. Ten patients with primary arterial hypertension of mild to moderate degree entered a randomized doubleblind cross-over study versus placebo. They were given oxprenolol + placebo or oxprenolol + sulphinpyrazone for 15 days, and then the treatments were crossed-over for a further 15 days. Oxprenolol significantly reduced blood pressure (161±3/101±1 vs 149±4/96±2 mmHg) and heart rate (72±3 vs 66±3 beats/min). During administration of the combination with sulphinpyrazone the blood pressure increased to its pretreatment level (156±5/101±2 mmHg). The effect of oxprenolol on heart rate was not influenced by the combined treatment (67±6 beats/min). The results may be explained by 1) sulphinpyrazone-induced inhibition of prostaglandin synthesis, which could interfere with the antihypertensive activity of oxprenolol, or 2) sulphinpyrazone-induced acceleration of the metabolism of oxprenolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00615965
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  • 5
    Electronic Resource
    Electronic Resource
    Transformation of cotton (Gossypium hirsutum L.) by Agrobacterium tumefaciens and regeneration of transgenic plants (1987)
    Springer
    Plant molecular biology 10 (1987), S. 105-116 
    Details
    ISSN: 1573-5028
    Keywords: Agrobacterium tumefaciens ; cotton ; Gossypium hirsutum L. ; regeneration ; transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cotton (Gossypium hirsutum L.) cotyledon tissues have been efficiently transformed and plants have been regenerated. Cotyledon pieces from 12-day-old aseptically germinated seedlings were inoculated with Agrobacterium tumefaciens strains containing avirulent Ti (tumor-inducing) plasmids with a chimeric gene encoding kanamycin resistance. After three days cocultivation, the cotyledon pieces were placed on a callus initiation medium containing kanamycin for selection. High frequencies of transformed kanamycin-resistant calli were produced, more than 80% of which were induced to form somatic embryos. Somatic embryos were germinated, and plants were regenerated and transferred to soil. Transformation was confirmed by opine production, kanamycin resistance, immunoassay, and DNA blot hybridization. This process for producing transgenic cotton plants facilitates transfer of genes of economic importance to cotton.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00016148
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  • 6
    Electronic Resource
    Electronic Resource
    The Effect of Amiodarone on Theophylline Pharmacokinetics in the Rat (1986)
    Springer
    Pharmaceutical research 3 (1986), S. 167-169 
    Details
    ISSN: 1573-904X
    Keywords: amiodarone ; theophylline ; pharmacokinetics ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Amiodarone is an investigational antiarrhythmic agent which has been implicated in reducing the activity of the hepatic mixed-function oxidase system. To evaluate this effect further, two groups of six male Sprague–Dawley rats each received theophylline (6 mg/kg, iv) preceded by either normal saline or amiodarone HC1 (100 mg/kg, iv). Blood samples were obtained serially for a period of 6 hr and the sera were assayed for theophylline by high-pressure liquid chromatography (HPLC). In rats pretreated with amiodarone, a significant 45% reduction in the mean (± SD) systemic clearance [0.057 (0.010) vs 0.031 (0.004) liter/hr/kg, P 〈 0.001] and a greater than 100% increase in the mean elimination half-life [2.03 (0.46) vs 4.29 (0.71) hr, P 〈 0.001] of theophylline were observed. These data demonstrate an acute inhibitory effect of amiodarone on the hepatic microsomal enzyme system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016366008696
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  • 7
    Electronic Resource
    Electronic Resource
    In vitro model systems of carcinogenesis: Interaction between c-Ha-ras oncogene and immortalized cells (1988)
    Springer
    Bulletin of experimental biology and medicine 105 (1988), S. 389-392 
    Details
    ISSN: 1573-8221
    Keywords: immortalization ; oncogenes ; transfection ; transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00835760
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  • 8
    Electronic Resource
    Electronic Resource
    Are mitochondria directly involved in biological mineralisation? (1969)
    Springer
    Calcified tissue international 3 (1969), S. 103-105 
    Details
    ISSN: 1432-0827
    Keywords: Mitochondrion ; Calcium ; Excretion ; Bone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058652
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of high dietary strontium levels on bone and egg shell calcium and strontium (1969)
    Springer
    Calcified tissue international 4 (1969), S. 180-184 
    Details
    ISSN: 1432-0827
    Keywords: Strontium ; Calcium ; Bone ; Shell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Des poules ont été nourries avec une alimentation riche en strontium stable. Des concentrations de strontium de 3000 p.p. m. à 50000 p.p.m. montre une augmentation nette en strontium du tibia, alors que le contenu en calcium n'est pas modifié. Les concentrations en calcium sérique diminue, lorsque le strontium alimentaire augmente. Le calcium des coquilles d'oeufs diminue progressivement avec l'augmentation du strontium alimentaire, alors que le contenu en strontium des coquilles présente une augmentation correspondante. Des analyses de diffraction par rayons X des os et des coquilles ne permettent pas de déterminer sous quelle forme le strontium est déposé.
    Abstract: Zusammenfassung Die Resultate einer Verfütterung von hohen stabilen Strontiumdosen an Hühnern werden erläutert. Strontiumzusätze zur Nahrung in der Höhe von 3000–50000 p.p.m. führten zu einer signifikanten Zunahme des Strontiumgehaltes der Tibia und verursachten keine wesentlichen Änderungen des Calciumgehaltes. Die Calciumkonzentration im Plasma verminderte sich, wenn der Nahrung ansteigende Strontiummengen zugegeben wurden. Mit zunehmendem Strontiumzusatz zur Nahrung zeigte der Calciumgehalt der Eischale eine fortlaufende Abnahme, während sich der Strontiumgehalt entsprechend erhöhte. Durch Röntgendiffraktionsanalysen der stark Strontium-haltigen Knochen und Eischalen konnte nicht festgestellt werden, in welcher Form das Strontium abgelagert wurde.
    Notes: Abstract The results of feeding high dietary levels of stable strontium to hens are reported. Dietary levels of strontium from 3,000 p.p.m. to 50,000 p.p.m. showed a significant increase in strontium content of the tibia bone and essentially no change in the calcium content. Plasma calcium concentration was shown to decrease with increasing dietary strontium treatment. Egg shell calcium showed a progressive decrease with increasing dietary strontium treatment, whereas the strontium content has a corresponding increase. X-ray diffraction analyses of bones and shells containing large amounts of strontium were unsuccessful in evaluating the from in which strontium was deposited.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279119
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  • 10
    Electronic Resource
    Electronic Resource
    Determination of45Calcium and14Carbon ascorbic acid in bone using a liquid scintillation system (1969)
    Springer
    Calcified tissue international 4 (1969), S. 202-209 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Radiocalcium ; Ascorbic acid ; Scintillimetry ; Radiocarbon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Les auteurs on décrit des méthodes pour la détermination de45Ca plus L-1-14C acide asorbique dans les os d'animaux aprés administration des deux isotopes. Calcium et acide asorbique ont été extraits totalement par l'acide trichloracétique a 6% des os a l'état frais en évitant de détruire l'acide asorbique. La détermination chimique du calcium et de l'acide asorbique selon les méthodes classique a été faite dans des portions de l'échantillon. La détermination de la radioactivité du calcium et de l'acide asorbique a été faite ensuite dans des portions du même échantillon. Du Triton a servi pour le scintillant liquide dans le compteur de scintillation liquide. Un procédé de détermination des deux isotopes dans le meme echantillon a été décrit. Différents critéres on été appliques a chacque étape afin d'établir la validité et les limites d'application de la méthode.
    Abstract: Zusammenfassung Eine Methode ist beschrieben, die die quantitative und radioaktive Bestimmung von45Ca und L-[-L14C] Ascorbinsäure in Knochen von Tieren, denen die beiden Isotopen verabreicht worden sind, erlaubt. Calcium und Ascorbinsäure werden quantitativ mit 6% Trichloressigsäure ausgezogen, wobei die Ascorbinsäure erhalten bleibt. Quantitative Analysen für Calcium und Ascorbinsäure werden nach bekannten Methoden in einem Teil des Extraktes bestimmt und die Bestimmung der Radioaktivität in einem anderen Anteil mit Hilfe eines Flüssigkeits-Szintillations-Zählers durchgeführt. Dem flüssigen Szintillanten wird Triton zugesetzt. Diese Versuchsanordnung ermöglicht außerdem die gleichzeitige Bestimmung der beiden Isotopen im Knochen-Extrakt. Die Methode wurde sorgfältig auf ihre Verwendbarkeit ausgewertet.
    Notes: Abstract Methods were developed for the determination of45Ca plus L-[1-14C] asorbic acid in bones of animals following administration of both isotopes. Asorbic acid and calcium were extracted quantitatively with 6% trichloracetic acid from fresh bone under such mild conditions that asorbic acid was not destroyed. The chemical determinations of calcium and ascorbic acid according to standard procedures were performed in aliquots of the same extract. The determination of the radioactivity of calcium and ascorbic acid were then carried out in aliquots of the same extract. A Triton-containing liquid scintillation fluid was employed for the radioassay of45Ca and L-[1-14C] ascorbic acid in the liquid scintillation spectrometer. A procedure allowing the determination of both isotopes in the same extract is described. A number of criteria were applied to each step, in order to determine the validity and limitations of the procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279123
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