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  • 1
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    Physiological variation in alpha-adrenoceptor-mediated arterial sensitivity: relation to agonist affinity (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-10-10
    Description: Vascular smooth muscle from different arteries of the rabbit varies in sensitivity to norepinephrine, even when factors known to contribute to this variation are excluded. Sensitivity to norepinephrine mediated through the alpha-adrenoceptor is linearly related to the agonist dissociation constant, but is not significantly related to receptor reserve. These results suggest that agonist affinity is the primary determinant of sensitivity to norepinephrine, at least in these arteries, and that this is a locally regulated characteristic which may account for regional sensitivity changes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bevan, J A -- Oriowo, M A -- Bevan, R D -- HL 32383/HL/NHLBI NIH HHS/ -- HL 32985/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1986 Oct 10;234(4773):196-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3018932" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteries ; Muscle Contraction/drug effects ; Muscle, Smooth, Vascular/*drug effects/physiology ; Norepinephrine/*pharmacology ; Rabbits ; Receptors, Adrenergic, alpha/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Sites of transition between functional systemic and cerebral arteries of rabbits occur at embryological junctional sites (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: The vascular smooth muscle of cerebral blood vessels is relatively insensitive to sympathomimetic stimulation compared with muscle from systemic vessels. The transition in the vertebral artery occurs just rostral to the emergence of that artery from the foramen of the lateral process of the atlas and in the internal carotid artery just before it enters the carotid canal. These sites in the adult correspond to embryological junctions between segments of the vertebral and internal carotid arteries derived from the primitive dorsal aortas and their branches with vessels originating locally from the bilateral longitudinal neural arteries. Topographic patterns of vascular properties may in some cases be explained by the different sites of origin of their primordial mesodermal cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bevan, J A -- New York, N.Y. -- Science. 1979 May 11;204(4393):635-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432670" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/embryology ; Animals ; Carotid Artery, Internal/embryology/*innervation ; Cerebral Arteries/embryology/innervation ; Muscle Contraction/drug effects ; Muscle, Smooth/drug effects/innervation ; Norepinephrine/*pharmacology ; Rabbits ; Vertebral Artery/embryology/*innervation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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