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  • Cell & Developmental Biology  (648)
  • INSTRUMENTATION AND PHOTOGRAPHY  (606)
  • 1985-1989  (741)
  • 1975-1979  (394)
  • 1960-1964  (80)
  • 1950-1954  (39)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological profile of the substituted beta-lactam L-659,286: A member of a new class of human PMN elastase inhibitors (1989)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 39 (1989), S. 47-53 
    Details
    ISSN: 0730-2312
    Keywords: elastase inhibitors ; β-lactams ; lung damage ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Human polymorphonuclear leukocyte elastase (PMN elastase) is inhibited by L-659, 286 (7α-methoxy-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triaz-in-3-yl)thio]methyl]-5-thia-1-aza-6R-bicyclo [4.2.O]oct-2-ene-2-pyrrolidine carboxamide-5,-dioxide) with a Ki of 0.4 μM. This inhibition is time-dependent, rapid, and only slowly reversible, with a t1/2 of 〉 3 days at 25°C. L-659, 286 is also highly selective for PMN elastase, as it does not inhibit thrombin, trypsin, papain, plasmin, chymotrypsin, or cathepsin G. L-659, 286 administered intratracheally inhibits lung damage caused by administration via the same route of human PMN elastase into hamsters. In marmosets, L-659, 286 is cleared from blood very rapidly after an intravenous injection but is recovered in bronchoalveolar lavage fluid for several hours after intratracheal administration.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240390106
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Airborne laser induced fluorescence system for measuring OH and other trace gases in the parts-per-quadrillion to parts-per-trillion range (1979)
    In:  Other Sources
    Details
    Publication Date: 2011-08-17
    Description: Described in detail is a laser induced fluorescence system which has been successfully interfaced with two aircraft sampling platforms (i.e., Sabreliner jet and an L-188C Electra). This system, which has been under development for four years, presently consists of the following major components: (1) a Nd-Yag laser driven oscillator-amplifier dye laser; (2) a sampling manifold with associated fluorescence detection optics; (3) an OH calibration chamber; (4) a laser beam steering assembly; and (5) sampling electronics and data processing hardware. During the last three years, this system has been flown some 50,000 air miles making tropospheric OH radical measurements over the latitude range of 70 N to 57 S. OH concentrations measured during these flights have ranged from 30 parts-per-quadrillion (3.7 x 10 to the 5th molecules/sq cm) at altitudes of 6 km to 0.8 parts-per-trillion (2.0 x 10 to the 7th molecules/sq cm) at 0.5 km. Computations have been completed which indicate that the existing aircraft system with modest modifications should also be capable of detecting natural tropospheric levels of NO, SO2, CH2O, NO2, HNO2, NO3, H2O2 and CS2 by using both conventional laser-induced fluorescence methodology and multiphoton techniques.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Review of Scientific Instruments; 50; Dec. 197
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
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    An intercomparison of nitric oxide measurement techniques (1985)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Results from an intercomparison of techniques to measure tropospheric levels of nitric oxide (NO) are discussed. The intercomparison was part of the National Aeronautics and Space Administration's Global Tropospheric Experiment and was conducted at Wallops Island, VA, in July 1983. Instruments intercompared included a laser-induced fluorescence system and two chemiluminescence instruments. The intercomparisons were performed with ambient air at NO mixing ratios ranging from 10 to 60 pptv and NO-enriched ambient air at mixing ratios from 20 to 170 pptv. All instruments sampled from a common manifold. The techniques exhibited a high degree of correlation among themselves and with changes in the NO mixing ratio. Agreement among the three techniques was placed at approximately + or - 30 percent. Within this level of agreement, no artifacts or species interferences were identified.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Journal of Geophysical Research (ISSN 0148-0227); 90; 12
    Format: text
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  • 4
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    A ground-based experimental test program to duplicate and study the spacecraft glow phenomenon (1985)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: The use of a plasma device, the Advanced Concepts Torus-I, for producing atoms and molecules to study spacecraft glow mechanisms is discussed. A biased metal plate, located in the plasma edge, is used to accelerate and neutralize plasma ions, thus generating a neutral beam with a flux approx. 5 x 10 to the 14th power/sq cm/sec at the end of a drift tube. Our initial experiments are to produce a 10 eV molecular and atomic nitrogen beam directed onto material targets. Photon emission in the spectral range 2000 to 9000 A from excited species formed on the target surface will be investigated.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Marshall Space Flight Center 2d Workshop on Spacecraft Glow; p 202-211
    Format: application/pdf
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  • 5
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    Telemycology - A novel approach to monitoring environmental microbial load in Space Station Freedom (1989)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: The currently available methods for monitoring environmental microbial load call for the cultivation of microbes on laboratory media, a time- and material-consuming task that is potentially hazardous. Telemycology proposed in this communication is designed to eliminate the need for growing microbes, especially fungi, on board the spacecraft and to shift the bulk of the work-load to the ground-based Microbiology Laboratory. The system is based on the principle of trapping microbial propagules on a membrane filter, treating it with a microbe-enhancing reagent, and examining under a microscope down-linked to the central laboratory equipped with a synchronized televideo, telerobotics, and image banking system.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: SAE PAPER 891542
    Format: text
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  • 6
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    Laser velocimetry applied to transonic and supersonic aerodynamics (1976)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Measurements obtained with laser velocimetry in a Mach 2.9 separated turbulent boundary layer and in the transonic flow past a two-dimensional airfoil section are presented and compared to data realized by conventional techniques. Agreement in mean velocities was realized where the pressure measurements could be considered reliable; however, in regions of instantaneous reverse velocities, the laser results were found to be consistent with the physics of the flow whereas the pressure data were not. Streamwise turbulence intensities are also presented. In the transonic airfoil study, velocity measurements obtained immediately outside the upper surface boundary layer of a 6-inch chord NACA 64A010 airfoil are compared to edge velocities inferred from surface pressure measurements. For free-stream Mach numbers of 0.6 and 0.8, the agreement in results was very good. "Dual scatter" optical arrangements in conjunction with a single particle, counter-type signal processor were employed in these investigations.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA-TM-X-73117 , A-6510
    Format: application/pdf
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  • 7
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    Measurements on the development of cascades in a tungsten-scintillator ionization spectrometer (1975)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: The response of a tungsten-scintillator ionization spectrometer to accelerated particle beams has been investigated. Results obtained from exposure of the approx. 1000 g/sq cm apparatus to 5, 10, and 15 GeV/c electrons and pions as well as to 2.1 GeV/nucleon C-12 and O-16 ions are presented. These results include cascade-development curves, fractions of the primary energy measured by the spectrometer, and resolutions of the apparatus for measuring the primary energies. For 15 GeV/c electrons, an average of about 82% of the incident energy is measured by the apparatus with resolution (normal standard deviation) of about 6%. For 15 GeV/c pions, an average of about 65% of the incident energy is measured with resolution of about 18%. The energy resolution improves with increasing energy and with increasing depth of the spectrometer.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Nuclear Instruments and Methods; 126; 1975
    Format: text
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    NASA TECHNICAL REPORTS
  • 8
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    New technique for single-scan T1 measurements using solid echoes (1978)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: A simple technique for single-scan T1 measurements in solids is proposed and analyzed for single exponential spin-lattice relaxation. In this technique, the direct spin heating caused by the sampling process is significantly reduced in comparison with conventional techniques by utilizing the 'solid echo' to refocus the magnetization. The applicability of this technique to both the solid and liquid phases is demonstrated.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Review of Scientific Instruments; 49; Aug. 197
    Format: text
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  • 9
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    Recent developments in parallel-grid, gas-scintillation proportional counters (1977)
    In:  Other Sources
    Details
    Publication Date: 2019-06-27
    Description: The problems of developing large-area, gas-scintillation proportional counters with high resolution are considered. It is found that simple large-area, parallel-grid proportional counters suffer from a variation in gain over the counter window. Some success has been achieved in overcoming this problem by focusing the charge cloud as it drifts into the multiplication region. Measurements are reported for various mixtures of argon and xenon as well as pure xenon.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Format: text
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  • 10
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    Laser velocimeter supersonic and transonic wind tunnel studies (1976)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Wind tunnel investigations of a shock-induced separated flow and the flow about a two-dimensional airfoil section at transonic speeds using laser velocimetry techniques are described. Laser velocimeter data are presented and compared with conventional pressure type measurements (pitot and static pressure probe measurements for the shock-induced separation, and surface pressure measurements for the two-dimensional airfoil section). In addition to these data comparisons, a simple optical arrangement for the incorporation of a Bragg cell in a laser velocimeter system is described. The effects of particle concentration gradients within a turbulent boundary layer on laser velocimeter measurements are also demonstrated.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Minnesota Symposium on Laser Anemometry; Oct 22, 1975 - Oct 24, 1975; Bloomington, MN
    Format: text
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    NASA TECHNICAL REPORTS
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