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  • Drosophila melanogaster  (3)
  • 1985-1989  (3)
  • 1975-1979
  • 1970-1974
  • 1935-1939
  • 1890-1899
  • 1
    Electronic Resource
    Electronic Resource
    Positive regulation of theDrosophila melanogaster G6PD gene by an insertion sequence (1989)
    Springer
    Biochemical genetics 27 (1989), S. 379-393 
    Details
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; glucose-6-phosphate dehydrogenase (G6PD) ; transposable genetic element ; positive regulation ; chromatin structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In a previous study, we have shown that the three high-G6PD activity mutants are characterized by insertion of the Ins1 sequence consisting of a core sequence flanked by two defective P elements (KP and KP'; the 32nd base of the KP was replaced by guanine in the KP') in front of exonI of the G6PD gene and that the sequence responsible for positive regulation of the G6PD gene expression might be the core sequence but not the flanking KP and KP' elements. The core sequence is composed of either one or two identical units in each mutant. In this report we present evidence (1) that insertion of the Ins1 sequence gives rise to overproduction of G6PD mRNA, (2) that the length and the 5′ end of G6PD mRNA do not differ in wild-type and three mutants, (3) that the insertion site of the Ins1 sequence is the same in the mutants, and (4) that each unit of the core sequence has a pair of DNase I-hypersensitive sites. The possibility exists that the binding of some regulatory proteins to the DNase I-hypersensitive sites might accelerate the transcription rate of the G6PD gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553905
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Positive regulation of theDrosophila melanogaster G6PD gene by an insertion sequence (1989)
    Springer
    Biochemical genetics 27 (1989), S. 379-393 
    Details
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; glucose-6-phosphate dehydrogenase (G6PD) ; transposable genetic element ; positive regulation ; chromatin structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In a previous study, we have shown that the three high-G6PD activity mutants are characterized by insertion of the Ins1 sequence consisting of a core sequence flanked by two defective P elements (KP and KP'; the 32nd base of the KP was replaced by guanine in the KP') in front of exonI of the G6PD gene and that the sequence responsible for positive regulation of the G6PD gene expression might be the core sequence but not the flanking KP and KP' elements. The core sequence is composed of either one or two identical units in each mutant. In this report we present evidence (1) that insertion of the Ins1 sequence gives rise to overproduction of G6PD mRNA, (2) that the length and the 5′ end of G6PD mRNA do not differ in wild-type and three mutants, (3) that the insertion site of the Ins1 sequence is the same in the mutants, and (4) that each unit of the core sequence has a pair of DNase I-hypersensitive sites. The possibility exists that the binding of some regulatory proteins to the DNase I-hypersensitive sites might accelerate the transcription rate of the G6PD gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02399667
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  • 3
    Electronic Resource
    Electronic Resource
    X-linked mutations that give rise to overproduction of glucose-6-phosphate dehydrogenase in Drosophila melanogaster (1986)
    Springer
    Biochemical genetics 24 (1986), S. 319-327 
    Details
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; glucose-6-phosphate dehydrogenase ; X-linked mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Two X-linked mutations that give rise to overproduction of glucose-6-phosphate dehydrogenase (G6PD) were found among the progenies of isogenic strains which had been subjected to selection for high G6PD activity. Mapping of the high-activity factor in these mutants was carried out using car Zw B sw males of low G6PD activity. As a result, the factor mapped 0.02–0.04 unit to the left of the Zw locus. The amount of the G6PD gene was also quantitated utilizing a cloned G6PD gene as a probe, but no significant difference was found between the mutants and low-G6PD activity flies which shared the same X, second, and third chromosomes with the mutants. These findings are consistent with our notion that the mutations might be regulatory mutations, possibly resulting from the insertion of a novel class of transposable genetic elements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00502798
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