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  • Cell & Developmental Biology  (454)
  • INSTRUMENTATION AND PHOTOGRAPHY  (287)
  • 1985-1989  (741)
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological profile of the substituted beta-lactam L-659,286: A member of a new class of human PMN elastase inhibitors (1989)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 39 (1989), S. 47-53 
    Details
    ISSN: 0730-2312
    Keywords: elastase inhibitors ; β-lactams ; lung damage ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Human polymorphonuclear leukocyte elastase (PMN elastase) is inhibited by L-659, 286 (7α-methoxy-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triaz-in-3-yl)thio]methyl]-5-thia-1-aza-6R-bicyclo [4.2.O]oct-2-ene-2-pyrrolidine carboxamide-5,-dioxide) with a Ki of 0.4 μM. This inhibition is time-dependent, rapid, and only slowly reversible, with a t1/2 of 〉 3 days at 25°C. L-659, 286 is also highly selective for PMN elastase, as it does not inhibit thrombin, trypsin, papain, plasmin, chymotrypsin, or cathepsin G. L-659, 286 administered intratracheally inhibits lung damage caused by administration via the same route of human PMN elastase into hamsters. In marmosets, L-659, 286 is cleared from blood very rapidly after an intravenous injection but is recovered in bronchoalveolar lavage fluid for several hours after intratracheal administration.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240390106
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  • 2
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    An intercomparison of nitric oxide measurement techniques (1985)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Results from an intercomparison of techniques to measure tropospheric levels of nitric oxide (NO) are discussed. The intercomparison was part of the National Aeronautics and Space Administration's Global Tropospheric Experiment and was conducted at Wallops Island, VA, in July 1983. Instruments intercompared included a laser-induced fluorescence system and two chemiluminescence instruments. The intercomparisons were performed with ambient air at NO mixing ratios ranging from 10 to 60 pptv and NO-enriched ambient air at mixing ratios from 20 to 170 pptv. All instruments sampled from a common manifold. The techniques exhibited a high degree of correlation among themselves and with changes in the NO mixing ratio. Agreement among the three techniques was placed at approximately + or - 30 percent. Within this level of agreement, no artifacts or species interferences were identified.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Journal of Geophysical Research (ISSN 0148-0227); 90; 12
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
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    A ground-based experimental test program to duplicate and study the spacecraft glow phenomenon (1985)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: The use of a plasma device, the Advanced Concepts Torus-I, for producing atoms and molecules to study spacecraft glow mechanisms is discussed. A biased metal plate, located in the plasma edge, is used to accelerate and neutralize plasma ions, thus generating a neutral beam with a flux approx. 5 x 10 to the 14th power/sq cm/sec at the end of a drift tube. Our initial experiments are to produce a 10 eV molecular and atomic nitrogen beam directed onto material targets. Photon emission in the spectral range 2000 to 9000 A from excited species formed on the target surface will be investigated.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: NASA. Marshall Space Flight Center 2d Workshop on Spacecraft Glow; p 202-211
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Telemycology - A novel approach to monitoring environmental microbial load in Space Station Freedom (1989)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: The currently available methods for monitoring environmental microbial load call for the cultivation of microbes on laboratory media, a time- and material-consuming task that is potentially hazardous. Telemycology proposed in this communication is designed to eliminate the need for growing microbes, especially fungi, on board the spacecraft and to shift the bulk of the work-load to the ground-based Microbiology Laboratory. The system is based on the principle of trapping microbial propagules on a membrane filter, treating it with a microbe-enhancing reagent, and examining under a microscope down-linked to the central laboratory equipped with a synchronized televideo, telerobotics, and image banking system.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: SAE PAPER 891542
    Format: text
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    NASA TECHNICAL REPORTS
  • 5
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    A 2-lambda laser-induced flurorescence field instrument for ground-based and airborne measurements of atmospheric OH (1985)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: A number of techniques have been proposed for detecting atmospheric OH radicals. Of these, the laser-induced fluorescence (LIF) technique has been used by the largest number of investigators. One of the problems arising in connection with the implementation of this technique is related to the perturbing effect of the UV (lambda approximately 282 nm) laser beam used for OH monitoring, while another problem relates to signal extraction. Several new LIF approaches have been or are currently under development with the objective to bring both problems under control. The present paper deals with the experimental features of one of these new approaches. The considered approach is referred to as 2-lambda laser-induced fluorescence (2-lambda LIF). It is shown that the 2-lambda LIF system provides significant advantages over earlier 1-lambda LIF OH measurement instruments operating at ambient pressure.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Journal of Geophysical Research (ISSN 0148-0227); 90; 12
    Format: text
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    NASA TECHNICAL REPORTS
  • 6
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    A two-photon laser-induced fluorescence field instrument for ground-based and airborne measurements of atmospheric NO (1985)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: This paper reports on a new two-photon laser-induced fluorescence (TP-LIF) sensor capable of making routine measurements at the few parts per trillion volume level. This direct spectroscopic detection method has been demonstrated to be a reliable instrument while performing both on the ground and in the air. As currently designed it is unique in being 'signal' rather than 'signal-to-noise' limited. The latter characteristic enables the TP-LIF sensor to make atmospheric measurements of NO under environmental conditions that might normally be considered unsuitable for a laser technique. These include clouds, rain, and, in general, high-atmospheric-aerosol loading conditions. Of special interest is the insensitivity of the TP-LIF NO instrument to changes in pressure while operating in the troposphere. This characteristic has enabled this sensor to be used to record real-time altitude profiles of NO. Future improvements should make possible two measurement opportunities: (1) NO flux measurements via the airborne eddy-correlation method and (2) nitrogen isotopic distribution measurements (e.g., (N-15)(0-16) versus (N-14)(0-16) as a means of identifying specific NO(x) sources.
    Keywords: INSTRUMENTATION AND PHOTOGRAPHY
    Type: Journal of Geophysical Research (ISSN 0148-0227); 90; 12
    Format: text
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    NASA TECHNICAL REPORTS
  • 7
    Electronic Resource
    Electronic Resource
    Changes in visual fields associated with web reduction in the spider family uloboridae (1987)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 192 (1987), S. 87-100 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: When visual fields of the primitive orb-weaver, Waitkera waitkerensis, are reconstructed using measurements taken from intact lenses and cross and longitudinal sections of the prosoma, they show that this species has complete visual surveillance, but that none of the visual fields of its eight eyes overlap. The more advanced orb-weaver, Uloborus glomosus, also has eight eyes, but each eye has a greater visual angle, giving this species a complex pattern of overlapping visual fields. Uloborids that spin reduced webs are characterized by reduction or loss of the four anterior eyes and other carapace modifications necessary for them to effectively monitor and manipulate their reduced webs. The eyes of these uloborids have greater visual angles than those of orb-weavers, resulting primarily from perimetric expansion of their retinal hemispheres. Additionally, the axes of their visual fields are more ventrally directed due to greater dorsal than ventral retinal expansion and to ventral redirection of the entire eye. Consequently, even though the anterior lateral eyes of the triangle-weaver Hyptiotes cavatus lack retinae, the species' six functional eyes permit complete visual surveillance and exhibit visual overlap. The single-line-weaver, Miagrammopes animotus, has lost its four anterior eyes, and with them much of the anterior vision and all of the visual overlap found in the other species. However, changes similar to those of H. cavatus permit this species to retain most if its dorsal and ventral visual surveillance. Thus, ocular changes act in consort to maintain relatively complete visual surveillance in the face of eye loss and other major carapace modifications necessary for the operation of reduced webs.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051920202
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  • 8
    Electronic Resource
    Electronic Resource
    Transformation of mouse bone marrow cells by transfection with a human oncogene related to c-myc is associated with the endogenous production of macrophage colony stimulating factor 1 (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 125 (1985), S. 403-412 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: We recently derived a series of transformed cell lines by transfecting mouse bone marrow cells highly enriched for macrophage progenitors with a newly described human gene, R-myc, which has homology to the c-myc oncogene. In this report, we show that these lines share some features characteristic of cells of the mononuclear phagocyte lineage. Specifically, all cell lines had macrophage-or monocytelike morphology, contained nonspecific esterase, were phagocytic for latex beads, secreted lysozyme, bore the Mac-1 antigen, and contained a minority of cells with Fc receptors. However, only a single monocytelike clone had appreciable numbers of cells which bore complement receptor 1, and none were phagocytic for antibody or complementcoated particles, or constitutively secreted Interleukin-1. All these cell lines secreted a growth factor capable of supporting the in vitro proliferation of bone marrow macrophages. Radiommunoassay and receptor binding studies indicate that this factor is colony stimulating factor 1.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041250307
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  • 9
    Electronic Resource
    Electronic Resource
    In vitro actions on hemopoietic cells of recombinant murine GM-CSF purified after production in Escherichia coli: Comparison with purified native GM-CSF (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 128 (1986), S. 421-431 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Recombinant murine GM-CSF produced in Escherichia coli was purified to homogeneity and tested in parallel with purified native GM-CSF. Both recombinant and native GM-CSF stimulated granulocyte and/or macrophage colony formation by adult and fetalmouse progenitor cells, and with adult marrow cells the specific activity of the recombinant GM-CSF (25 × 108 U/mg) was similar to that of the native form (15 × 108 U/mg). At high concentrations (〉 200 U/ml), both forms of GM-CSF also stimulated eosinophil colony formation by adult marrow cells and, at very high concentrations (〉 800 U/ml), megakaryocyte and some erythroid and mixed-erythroid colony formation. Recombinant GM-CSF was as effective in stimulating the proliferation of the GM-CSF-dependent cell line FD as the native molecule. Both recombinant and native GM-CSF were able to induce partial differentiation in colonies of WEHI-3B myeloid leukemic cells. Recombinant GM-CSF competed effectively for the binding of 125l-labeled native GM-CSF to hemopoietic cells, and anti-serum to recombinant GM-CSF also neutralized the biological activity of native GM-CSF. The bacterially synthesized GM-CSF was a slightly more effective stimulus for megakayocyte colony formation than then native molecule. The demonstration that purified bacterially synthesized GM-CSF is biologically active in vitro now permits studies to be undertaken on the in vivo effects of this material.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041280311
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  • 10
    Electronic Resource
    Electronic Resource
    PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 132 (1987), S. 65-72 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The platelet-derived growth factor (PDGF) modulated growth response of the MG-63 human osteosarcoma cell line, which neither expresses c-sis mRNA nor secretes a PDGF analogue, was characterized. Scatchard analysis demonstrated that the MG-63 cells have 23,000 receptors per cell with a kd of 5 × 10-11 M. The receptor became phosphorylated, in a PDGF concentration-dependent manner, when 32P-orthophosphate-labeled cells were treated with PDGF for 3 h at 4°C. The phosphorylated receptor was identified by autora-diography and gel electrophoresis after isolation of the 32P-labeled receptor using a solid-phase monoclonal antibody directed against phosphotyrosine. Binding of the receptor to the antibody was inhibited by 5 mM phenyl phosphate, further suggesting that PDGF stimulated tyrosine-specific receptor autophosphorylation. In addition, treatment of MG-63 cells with PDGF for 3 h at 37°C induced a 7.5-fold increase in c-myc mRNA accumulation as analyzed on Northern gels. However, MG-63 cells grew equally well in either serum-(which contains PDGF) or plasma-(which does not) supplemented medium. Furthermore, PDGF did not stimulate DNA synthesis in growth arrested MG-63 cells, nor did it potentiate DNA synthesis modulated by somatomedin C. Thus MG-63 cells are a naturally occurring cell variant in which PDGF stimulates c-myc expression but does not modulate mitogenesis.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041320109
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