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  • Elsevier  (140)
  • Wiley-Blackwell  (15)
  • 1985-1989  (85)
  • 1980-1984  (70)
  • 1
    Electronic Resource
    Electronic Resource
    Interaction of the antimalarial drug fluoroquine with DNA, tRNA, and poly(A): 19F-NMR chemical-shift and relaxation, optical absorption, and fluorescence studies (1981)
    New York : Wiley-Blackwell
    Biopolymers 20 (1981), S. 435-449 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The interaction of the fluorinated antimalarial drug fluoroquine [7-fluoro-4-(diethyl-amino-1-methylbutylamino)quinoline] with DNA, tRNA, and poly(A) has been investigated by optical absorption, fluorescence, and 19F-nmr chemical-shift and relaxation methods. Optical absorption and fluorescence experiments indicate that fluoroquine binds to nucleic acids in a similar manner to that of its well-known analog chloroquine. At low drug-to-base pair ratios, binding of both drugs appears to be random. Fluoroquine and chloroquine also elevate the melting temperature (Tm) of DNA to a comparable extent. Binding of fluoroquine to DNA, tRNA, or poly(A) results in a downfield shift of about 1.5 ppm for the 19F-nmr resonance. The chemical shift of free fluoroquine depends on the isotopic composition of the solvent (D2O vs H2O). The solvent isotope shift is virtually eliminated by fluoroquine binding to any one of the nucleic acids. 19F-nmr relaxation experiments were carried out to measure the spin-lattice relaxation time (T1), 19F{1H} nuclear Overhauser effect (NOE), off-resonance intensity ratio (R), off-resonance rotating-frame spin-lattice relaxation time (T1ρoff), and linewidth for fluoroquine in the nucleic acid complexes. By accounting for intramolecular proton-fluorine dipolar and chemical-shift anisotropy contributions to the fluorine relaxation, all of the relaxation parameters for the fluoroquine-DNA complex can be well described by a motional model incorporating long-range DNA bending on the order of a microsecond and an internal motion of the drug on the order of a nanosecond. Selective NOE experiments indicate that the fluorine in the drug is near the ribose protons in the RNA complexes, but not in the DNA complex. Details of the binding evidently differ for the two types of nucleic acids. This study provides the foundation for an investigation of fluoroquine in intact cells.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1981.360200303
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  • 2
    Electronic Resource
    Electronic Resource
    Prediction of DNA structure from sequence: A build-up technique (1989)
    New York : Wiley-Blackwell
    Biopolymers 28 (1989), S. 1195-1222 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A build-up technique has been devised that permits prediction of DNA structure form sequence. No experimental information is employed other than the force field parameters. This strategy for dealing with the multiple minimum problem requires a supercomputer to make the necessary global searches. The number of energy minimization trials that were made for each of the 16 deoxydinucleoside monophosphate conformational building blocks of DNA was 1944. As a test case, the minimum energy conformations of d(GpC) and d(CpG) to 5.5 kcal/mole were then combined to generate energy-minimized structures for d(CpGpC). The number of trials that were made for d(CpGpC) was 3752. Minima for this single-stranded trimer to 15 kcal/mole were then employed to search for minimum energy conformations of the duplex d(CpGpC) · d(GpCpG). The number of starting conformations that were utilized at this stage was 1514. The lowest energy duplex had a Z-II-DNA conformation, followed by a B-DNA form at 1.2 kcal/mole. The A- and Z-I-forms as well as many novel Watson-Crick base-paired structures were found at higher energy. Finally, energy-minimized structures of d(CG)6 in Z-II and B-DNA conformations were computed using torsion angles from the analogous duplex trimer minima.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360280703
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  • 3
    Electronic Resource
    Electronic Resource
    19F-NMR study of DNA bis-intercalation (1983)
    New York : Wiley-Blackwell
    Biopolymers 22 (1983), S. 2497-2500 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360221202
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  • 4
    Electronic Resource
    Electronic Resource
    Classical limit of quantum mechanics in the large (1983)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 23 (1983), S. 99-113 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Hilbert space may be regarded as a convenient standard approximation by interpolation and extrapolation to a unitary space, in general decomposable into a sum of semisimple spaces. In the limit we expect a particle theory expanded in powers of h according to the number of interacting particles. In the classical limit h tending to zero, phase space, with equations of motion reducible to Hamiltonian form, replaces Hilbert space. The modification of states by observing them is taken care of by considering probability distributions of petty ensembles. If the equations for any single observer can be made autonomous by replacing empirical time by universal time with an arrow we have a causal system. We then obtain the relation between probability and negentropy required for the second law of thermodynamics. An approximate Newtonian theory provides proximate particles with internal and external variables and admits the Poincaré group. For the internal variables we have approximately the Breit interaction. For the external variables we have equivalence for observers of the homogeneous Lorentz group of relativity. We introduce grand ensembles of ultimate particles, and nebulae as proximate particles in the large. We assume the Einstein principle of equivalence for the ten parameter set of observers suggested by relativity and suppose the second law of thermodynamics holds for each observer. The Einstein law of gravitation follows in classical theory to the order of the reciprocal of the large constant, in general with positive natural curvature as well as that corresponding to mass. Replacing particle interactions by fields we include them in classical theory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560230112
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  • 5
    Electronic Resource
    Electronic Resource
    Cytological and cytochemical investigations of development from dormant gemmules of the marine sponge, Haliclona loosanoffi (1987)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 193 (1987), S. 99-116 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Vernalized gemmules of the marine sponge Haliclona loosanoffi were cultured at 20°C, fixed at 24-hour intervals (0-11 days), and processed for light microscopy by using a variety of absorption and fluorescent staining methods. The cytochemistry and morphology of development were compared to the well-studied developmental patterns of freshwater sponges and to the patterns described in the marine sponge Suberites domuncula. The precocious development of H. loosanoffi gemmules involves early morphogenesis occurring within the unhatched gemmule, as opposed to the patterns in freshwater sponges, where most development occurs after the gemmule hatches. Definitive sponge tissue surrounding a single osculum is present 9 days after release from dormancy.
    Additional Material: 25 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051930110
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  • 6
    Electronic Resource
    Electronic Resource
    A continuous, farm-scale, solid-phase fermentation process for fuel ethanol and protein feed production from fodder beets (1984)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 26 (1984), S. 1098-1107 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Fuel ethanol (95%) was produced from fodder beets in two farm-scale processes. In the first process, involving conventional submerged fermentation of the fodder beets in a mash, ethanol and a feed (PF) rich in protein, fat, and fiber were produced. Ethanol yields of 70 L/metric ton (7 gal/ton) were obtained; however, resulting beers had low ethanol concentrations [3-5% (v/v)]. The high viscosity of medium and low sugar, beet mashes caused mixing problems which prevented any further increase of beet sugar in the mash. The severely limited the maximum attainable ethanol concentration during fermentation, thereby making the beer costly to distill into fuel ethanol and the process energy inefficient. In order to achieve distillably worthwhile ethanol concentrations of 8-10% (v/v), we developed and tested a solid-phase fermentation process (continuous). In preliminary trials, this system produced fermented pulp with over 8% (v/v) ethanol corresponding to an ethanol yield of 87 L/metric ton (21 gal/ton). Production costs with this novel process are $0.47/L ($1.77/gal) and the energy balance is 2.11. These preliminary cost estimates indicate that fodder beets are potentially competitive with corn as an ethanol feedstock. Additional research, however, is warranted to more precisely refine individual costs, energy balances and the actual value of the PF.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260260913
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  • 7
    Electronic Resource
    Electronic Resource
    Werkstoffe für die direkte Nutzung der SonnenstrahlungVortrag, gehalten anläßlich der Berliner Werkstoff-Tage 1987 und erstveröffentlicht in der Zeitschrift der Förderer des Bergbaus und des Hüttenwesens an der Technischen Universität Berlin e.V., Heft Nr. 2/1987 - Nr. 1/1988, S.51/58, publiziert mit freundlicher Genehmigung der Veranstalter. (1988)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 19 (1988), S. 213-219 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Materials for Conversion of Solar EnergyMaterials for thermal, electrical and chemical conversion of solar energy are reviewed together with information on the physical basis common to all kinds of conversion. The natural and economical limits of the various techniques are mentioned.
    Notes: Es wird ein Überblick über die Werkstoffe gegeben, die für die thermische, elektrische und chemische Umwandlung der Sonnenstrahlung in Frage kommen, wobei die allen Umwandlungsarten gemeinsamen physikalischen Vorgänge besprochen werden. Die natürlichen und wirtschaftlichen Grenzen der verschiedenen Verfahren kommen zur Sprache.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19880190702
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  • 8
    Electronic Resource
    Electronic Resource
    The surface rejuvenation theory of wall turbulence for momentum, heat and mass transfer: Application to moderate and high schmidt (Prandtl) fluids (1985)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 31 (1985), S. 1614-1620 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The surface rejuvenation model of the turbulent burst process, already developed for the momentum and heat transfer processes, is applied to the field of mass transfer. The range of applicability of the theory, previously shown to be valid for the Prandtl number range 0.7 to 64 is extended to Schmidt numbers of 6,500 without introducing any new parameters. Concentration and temperature profiles for high Schmidt and Prandtl numbers are in agreement with experimental data. Theoretical expressions for Sherwood and Stanton numbers are calculated and shown to be in agreement with experimental data over five orders of magnitude.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690311005
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  • 9
    Electronic Resource
    Electronic Resource
    Molecular-Mechanical studies of the mismatched base analogs of d(CGCGAATTCGCG)2:d(CGTGAATTCGCG)2, d(CGAGAATTCGCG)2, d(CGCGAATTCACG)2, d(CGCGAATTCTCG)2, and d(CGCAGAATTCGCG)·d(CGCGAATTCGCG) (1984)
    New York : Wiley-Blackwell
    Biopolymers 23 (1984), S. 2901-2929 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Molecular-mechanical simulations have been carried out on “mismatched base” analogs of the DNA double-helical structure d(CGCGAATTCGCG)2, in which the base pairs CG at the 3 and 10 positions have been replaced by CA, AG, TC, and TG base pairs, as well as an insertion analog in which an extra adenine has been incorporated into one strand of the above structure between bases 3 and 4. The results of these simulations (calculated relative stabilities, structures, and nmr ring-current shifts) have been compared with calorimetric and nmr data. The calculated relative stabilities of the double-helical parent dodecamer and the various “wobble” base pairs qualitatively correlate with the experimental melting temperatures. The base-pairing structure for the GT wobble pair is in agreement with that previously determined from nmr experiments. For the GA base pair, the structure with both bases anti has a slightly more favorable energy from base pairing and stacking than a structure with non-Watson-Crick H-bonding with adenine syn, in agreement with nmr experiments. The CA wobble base is calculated to favor an adenine 6NH2 … cytosine N3 H-bond over cytosine 4NH2 … adenine N1, again, in agreement with nmr experiments. There is no definitive experimental data on the TC base pair, but the existence of (somewhat long and weak) H-bonds involving cytosine 4NH2 … thymine 4CO and cytosine N3 … thymine HN3 seems reasonable. We find a structure in which the extra adenine base of the insertion analogs sits “inside” the double helix.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360231214
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  • 10
    Electronic Resource
    Electronic Resource
    Thermospray mass spectrometry of thiazides. A novel elimination and rearrangement resulting from a molecular adduct ion (1988)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 2 (1988), S. 25-27 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290020202
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