Publication Date:
1989-08-18
Description:
The expression of proto-oncogenes representative of several functional categories has been investigated during development of mouse male germ cells. The c-raf proto-oncogene and three members of the c-ras gene family were expressed in mitotically active stem cells, throughout the prophase of meiosis and to varying extents in post-meiotic cell types. In contrast, the nuclear proto-oncogenes c-fos, c-jun, and c-myc were specifically expressed at high levels in type B spermatogonia. High levels of c-myc and c-jun RNAs were also detected in spermatocytes early in the prophase of meiosis. The type B spermatogonia represent the last mitotic cell division before entry into meiotic prophase; therefore, these nuclear proto-oncogenes may be involved in altering programs of gene expression at this developmental transition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolfes, H -- Kogawa, K -- Millette, C F -- Cooper, G M -- CA 21082/CA/NCI NIH HHS/ -- CA 28946/CA/NCI NIH HHS/ -- HD 15269/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1989 Aug 18;245(4919):740-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute, Boston, MA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2475907" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Nucleus/*metabolism
;
DNA-Binding Proteins/genetics
;
*Gene Expression Regulation
;
Male
;
*Meiosis
;
Mice
;
Nucleic Acid Hybridization
;
Proto-Oncogene Proteins/genetics
;
Proto-Oncogene Proteins c-fos
;
Proto-Oncogene Proteins c-jun
;
Proto-Oncogene Proteins c-myc
;
Proto-Oncogene Proteins c-raf
;
Proto-Oncogene Proteins p21(ras)
;
*Proto-Oncogenes
;
RNA/analysis
;
Spermatids/metabolism
;
Spermatocytes/metabolism
;
*Spermatogenesis
;
Spermatogonia/metabolism
;
Spermatozoa/analysis/metabolism/*ultrastructure
;
Transcription Factors/genetics
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
