ISSN:
1573-9171
Keywords:
acidity
;
basicity
;
2(1H)-pyrimidinethiones
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The acid-base properties of 4,6-dimethyl- and 4,6-diamino-2(1H)-pyrimidinethiones (1 and2) were investigated by potentiometric titration. Dissosiation of1 and protonation of its anion occur in two steps, the first of which affords the deprotonated dimer [HA2)−. The relative stability of the dimer depends on the nature of the solvent. The effect of kinetic factors on the acid-base behavior of1 was elucidated by comparing the results of potentiometric titrations carried out under various kinetic conditions. It was concluded that the difference between the acid-base properties of1 and2 results from the electron-donating effect of the amino groups.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00700162
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