Publication Date:
1994-09-23
Description:
Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor activation. Previous results suggest that the site for both the induction and expression of this form of LTP is presynaptic. Experimental elevation of cyclic adenosine 3',5'-monophosphate (cAMP) both mimics and interferes with tetanus-induced mossy fiber LTP, and blockers of the cAMP cascade block mossy fiber LTP. It is proposed that calcium entry into the presynaptic terminal may activate Ca(2+)-calmodulin-sensitive adenylyl cyclase I which, through protein kinase A, causes a persistent enhancement of evoked glutamate release.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weisskopf, M G -- Castillo, P E -- Zalutsky, R A -- Nicoll, R A -- New York, N.Y. -- Science. 1994 Sep 23;265(5180):1878-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neuroscience Graduate Program, University of California, San Francisco 94143-0450.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7916482" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium/metabolism
;
*Carbazoles
;
Colforsin/pharmacology
;
Cyclic AMP/*metabolism
;
Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors/metabolism
;
Glutamates/metabolism/pharmacology
;
Glutamic Acid
;
Guinea Pigs
;
Hippocampus/*physiology
;
In Vitro Techniques
;
Indoles/pharmacology
;
Isoquinolines/pharmacology
;
*Long-Term Potentiation/drug effects
;
Models, Biological
;
Nerve Fibers/*physiology
;
Presynaptic Terminals/metabolism
;
Pyramidal Cells/physiology
;
Pyrroles/pharmacology
;
*Sulfonamides
;
Synaptic Transmission/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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