Publication Date:
1994-01-07
Description:
Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, interleukin-11, and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenically related to the p91 subunit of the interferon-stimulated gene factor-3 alpha (ISGF-3 alpha). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3 alpha p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1 associated with gp130. These data indicate that Jak family protein kinases may participate in IL-6 signaling and that APRF may be activated in a complex with gp130.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lutticken, C -- Wegenka, U M -- Yuan, J -- Buschmann, J -- Schindler, C -- Ziemiecki, A -- Harpur, A G -- Wilks, A F -- Yasukawa, K -- Taga, T -- New York, N.Y. -- Science. 1994 Jan 7;263(5143):89-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Biochemistry, RWTH Aachen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8272872" target="_blank"〉PubMed〈/a〉
Keywords:
*Antigens, CD
;
Base Sequence
;
Cytokine Receptor gp130
;
Cytokines/pharmacology
;
DNA-Binding Proteins/*metabolism
;
Humans
;
Interferon-Stimulated Gene Factor 3
;
Interferon-Stimulated Gene Factor 3, gamma Subunit
;
Interferon-gamma/pharmacology
;
Interleukin-6/*pharmacology
;
Janus Kinase 1
;
Membrane Glycoproteins/*metabolism
;
Molecular Sequence Data
;
Phosphorylation
;
Protein-Tyrosine Kinases/*metabolism
;
STAT1 Transcription Factor
;
STAT3 Transcription Factor
;
Signal Transduction
;
*Trans-Activators
;
Transcription Factors/metabolism
;
Tumor Cells, Cultured
;
Tyrosine/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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