Publication Date:
1993-02-12
Description:
The maintenance of transplantation tolerance induced in adult mice after short-term treatment with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4+ T cells from tolerant mice disabled naive lymphocytes so that they too could not reject the graft. The naive lymphocytes that had been so disabled also became tolerant and, in turn, developed the capacity to specifically disable other naive lymphocytes. This process of "infectious" tolerance explains why no further immunosuppression was needed to maintain long-term transplantation tolerance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Qin, S -- Cobbold, S P -- Pope, H -- Elliott, J -- Kioussis, D -- Davies, J -- Waldmann, H -- New York, N.Y. -- Science. 1993 Feb 12;259(5097):974-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Cambridge, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8094901" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal/therapeutic use
;
Antigens, CD2
;
Antigens, CD4/immunology
;
Antigens, CD8/immunology
;
Antigens, Differentiation, T-Lymphocyte/analysis/immunology
;
CD4-Positive T-Lymphocytes/*immunology
;
Graft Rejection/immunology
;
*Immune Tolerance
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred CBA
;
Mice, Transgenic
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Receptors, Immunologic/analysis/immunology
;
Skin Transplantation/*immunology
;
Spleen/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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