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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 97 (1993), S. 8250-8253 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 97 (1993), S. 8808-8811 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    R & D management 22 (1992), S. 0 
    ISSN: 1467-9310
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: The discovery and development of a new therapeutic agent may take five to ten years, cost in excess of £90m with a significant risk of product failure, due either to lack of safety or efficacy. Pharmaceutical companies require a new product every three to five years in order to sustain growth. This need is often met by licensing a product from a competitor. The evaluation of a potential licensing opportunity is a complex task in technology transfer since firstly, the time frame for decision taking is markedly foreshortened compared with the usual time involved when developing a drug from within the company. In addition the therapeutic field may be unfamiliar to the company personnel. The evaluation process involves a parallel but closely linked activity involving pharmacologists, toxicologists, pharmacy, pharmaceutical physicians, strategic marketing, legal experts as well as representatives from the major territorial international markets. This paper attempts to identify some problems in technology transfer which include organisational, attitudinal and behavioural factors. Possible topics for future research are identified.
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 24 (1991), S. 3291-3299 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 24 (1991), S. 1071-1076 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 24 (1991), S. 1064-1070 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1434-601X
    Keywords: 21.60.Cs ; 23.20.-g ; 27.60.+j
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The γ-decay and half life of the t1/2=60(3) ns Iπ=8+ isomer in100Cd have been studied with a recoil catcher setup inside the multidetector π-array OSIRIS. Evaporation neutrons and charged particles from the reaction58Ni+46Ti were measured in coincidence with delayed γ-rays. Six new γ-ray transitions with intensities of 1–10% of the main γ-ray cascade were found, two new states established and firm spin-parity assignments were made to all states below the isomer. The new states were identified as the 4+ and 6+ members of the proton πg9/2 −2 multiplet.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Biology and fertility of soils 10 (1990), S. 50-56 
    ISSN: 1432-0789
    Keywords: Sulfonate ; C-bonded sulfur ; Ester sulfate ; Organic sulfur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Several forests of varying elevations, soils and vegetation were studied to evaluate the relative importance of sulfonate S, amino acid S, and ester sulfate as constituents of soil organic S. Suflonate S exceeded 40% of total S in the O1 horizon of all but one site examined, and comprised at least 50% of total S in the O2 horizons of 14 out of 18 study sites examined. Sulfonate pool sizes, on a percentage basis, tended to decrease with increasing sample depth within the mineral horizons, but sulfonate S was still a major form of organic S in the C horizon. Amino-acid S pool sizes were, as a general rule, lower than those for sulfonate in the O1 and O2 horizons, and lower than those for both ester sulfate and sulfonate when mineral soil horizons were considered. In no case did amino-acid S represent〉25% of total S. Amino-acid S decreased with increasing depth at all but one site examined. Ester sulfate pool sizes were generally less than those of sulfonate S and greater than those of amino-acid S. This trend was observed with the O1, O2, and A horizons, but it was not apparent with samples from the intermediate and lowest soil horizons, where ester sulfate levels exceeded those for sulfonate S in 4 out of 8 and 5 out of 14 sites, respectively, in these latter horizons. Although there were some exceptions, collectively, the data suggest that sulfonate S is a major form of organic S in forest soils, irrespective of depth.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Biology and fertility of soils 10 (1991), S. 281-284 
    ISSN: 1432-0789
    Keywords: Sulfate concentration ; Saturation kinetics ; Organic S ; Mobilization ; Potential ; Net accumulation ; Saturation ; Acidic precipitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Increasing the sulfate concentration and concomitant increases in the organic S concentration failed to exert any effect on organic S mobilization in samples collected from all depths within the mineral soil profile, from 15 sites differing in soil type, vegetation, and geographic location. Mobilization capacities at saturating concentrations of sulfate for organic S formation generally tended to increase with increasing depth. The potentials for the accumulation of organic S with various sulfate inputs exhibited saturation kinetics similar to those observed for organic S formation; values for the former parameter ranged from 3×10-3 to 12.6 μmol S g−1 dry weight 24 h-1 for the uppermost (A, E) soil horizons, 3 nmol to 10 μmol S g-1 dry weight 24 h−1 for intermediate (primarily AB) soil horizons, and from 3 nmol to 13.4 μmol S g-1 dry weight 24 h−1 for the lowermost (B, C) soil horizons. Irrespective of depth, the Fullerton, Tarklin, and Loblolly sites in Tennessee and the Florida site showed the least net accumulation of organic S at saturation (〈0.2 μmol S g-1 dry weight 24 h−1 for all horizons examined), while the Duke Forest (North Carolina), Douglas Fir (Washington), Whiteface (New York) and the Howland (Maine) sites had the highest potential net accumulation of organic S at saturation (〉1.0 μmol S g-1 dry weight 24 h-1 for most horizons examined).
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  • 10
    ISSN: 1432-0789
    Keywords: Sulfate adsorption ; Organic S formation ; Organic S mobilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Forest and grassland soils that contained varying amounts of Fe and Al were collected from England and Wales. Fractionation of free Fe and Al was accomplished to determine which components affected sulfate adsorption. Organic Fe and Al were the dominant fractions in most soil horizons and high amounts of these organically bound metals and, to some extent, crystalline Fe oxide were associated with high sulfate adsorption potentials. These adsorption potentials reflected naturally occurring amounts of absorbed sulfate and ester sulfate. Overall, the C content exhibited a positive relationship with sulfate adsorption potentials. Soils with a high C content also exhibited high rates of organic S formation. The rate of organic S mobilization was greater in soils with higher amounts of soluble sulfate. Organic S was the largest pool and, typically, sulfonate S was the most abundant constituent of the organic pool.
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