Publication Date:
1994-04-22
Description:
Angiogenesis depends on the adhesive interactions of vascular cells. The adhesion receptor integrin alpha v beta 3 was identified as a marker of angiogenic vascular tissue. Integrin alpha v beta 3 was expressed on blood vessels in human wound granulation tissue but not in normal skin, and it showed a fourfold increase in expression during angiogenesis on the chick chorioallantoic membrane. In the latter assay, a monoclonal antibody to alpha v beta 3 blocked angiogenesis induced by basic fibroblast growth factor, tumor necrosis factor-alpha, and human melanoma fragments but had no effect on preexisting vessels. These findings suggest that alpha v beta 3 may be a useful therapeutic target for diseases characterized by neovascularization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brooks, P C -- Clark, R A -- Cheresh, D A -- CA45726/CA/NCI NIH HHS/ -- CA50286/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1994 Apr 22;264(5158):569-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7512751" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal
;
Blood Vessels/metabolism
;
Chick Embryo
;
Fibroblast Growth Factor 2/pharmacology
;
Granulation Tissue/*blood supply/metabolism
;
Humans
;
Integrins/biosynthesis/immunology/*physiology
;
Laminin/analysis
;
Melanoma/blood supply/metabolism
;
Neovascularization, Pathologic/*metabolism
;
Receptors, Cytoadhesin/biosynthesis/immunology/*physiology
;
Receptors, Vitronectin
;
Skin/blood supply/metabolism
;
Tumor Necrosis Factor-alpha/pharmacology
;
von Willebrand Factor/analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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