ALBERT

Description: Hyperthermia, in conjunction with radiation and chemotherapy for treatment of cancers, is an area of current concern. Experiments have shown that hyperthermia can increase the potency of many chemotherapy drugs and the effectiveness of radiation for treating cancer. A combination of whole body or regional hyperthermia with chemotherapy or radiation should improve treatment results. Conventional methods for inducing whole body hyperthermia, such as exposing a patient in a radiant cabinet or under a hot water blanket, conduct heat very slowly from the skin to the body core. Thus a more efficient system, such as the three-plate electric-field hyperthermia applicator (EHA), is developed. This three-plate EHA has one top plate over and two lower plates beneath the patient. It is driven at 27.12 MHz with 500 Watts through a matching circuit. Using this applicator, a 50 kg pig was successfully heated to 42 C within 45 minutes. However, phantom and animal studies have indicated non-uniform heating near the side of the body. In addition, changes in the size and distance between the electrode plates can affect the heating (or electromagnetic field) pattern. Therefore, numerical models using the method of moments (MOM) or the finite difference time domain (FDTD) technique are developed to optimize the heating pattern of this EHA before it is used for human trials. The accuracy of the numerical modeling has been achieved by the good agreement between the MOM and FDTD results for the three-plate EHA without a biological body. The versatile FDTD technique is then applied to optimize the EHA design with a human body. Both the numerical and measured data in phantom blocks will be presented. The results of this study will be used to design an optimized system for whole body or regional hyperthermia.

Description: Variable narrow-line emission at 511 keV, due to positron annihilation, has been observed from the region of the Galactic center for over a decade with high-resolution Ge spectrometers. The variable nature of this emission suggests that a significant fraction of the observed radiation is produced by a single source in the central region of the Galaxy. Recent observations with an imaging gamma-ray spectrometer of low energy resolution have revealed a daylong burst of annihilation radiation from the X-ray source 1E 1740.7-2042 located at an angular distance of 0.9 deg from the Galactic center and aligned with a dense molecular cloud. It is proposed that the variable narrow 511 keV line emission is due to positrons released impulsively (time scale of about 1 day) from 1E 1740.7-2942 into the molecular cloud where they slow down and annihilate on a longer time scale of up to a year.