ISSN:
1573-8221
Keywords:
interferon
;
thymus
;
cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Changes in the thymus of male Wistar rats were studied under a light microscope at various times after intranasal administration of α-interferon. The relative mass of the organ, the cortex volume, the total number of cells, the number of small and medium lymphocytes, and the number of mitoses decrease 14 days after interferon administration. At the same time, the number of macrophages, neutrophils, mature plasmacytes, eosinophils, and erythrocytes increases, and mast cells appear. Thus, α-interferon probably suppresses the formation of T cells, facilitates allergization of the organism, and increases the permeability of the vascular endothelium.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445735
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