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  • 1
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    Vaccinia virus: a tool for research and vaccine development (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-06-21
    Description: Vaccinia virus is no longer needed for smallpox immunization, but now serves as a useful vector for expressing genes within the cytoplasm of eukaryotic cells. As a research tool, recombinant vaccinia viruses are used to synthesize biologically active proteins and analyze structure-function relations, determine the targets of humoral- and cell-mediated immunity, and investigate the immune responses needed for protection against specific infectious diseases. When more data on safety and efficacy are available, recombinant vaccinia and related poxviruses may be candidates for live vaccines and for cancer immunotherapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moss, B -- New York, N.Y. -- Science. 1991 Jun 21;252(5013):1662-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2047875" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteriophages/genetics ; Gene Expression ; Genetic Engineering/methods ; *Genetic Vectors ; Humans ; Recombinant Proteins ; *Vaccines, Synthetic ; *Vaccinia virus/genetics/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-01-26
    Description: A synthetic peptidemimetic substrate of the human immunodeficiency virus 1 (HIV-1) protease with a nonhydrolyzable pseudodipeptidyl insert at the protease cleavage site was prepared. The peptide U-81749 inhibited recombinant HIV-1 protease in vitro (inhibition constant Ki of 70 nanomolar) and HIV-1 replication in human peripheral blood lymphocytes (inhibitory concentration IC50 of 0.1 to 1 micromolar). Moreover, 10 micromolar concentrations of U-81749 significantly inhibited proteolysis of the HIV-1 gag polyprotein (p55) to the mature viral structural proteins p24 and p17 in cells infected with a recombinant vaccinia virus expressing the HIV-1 gag-pol genes. The HIV-1 like particles released from inhibitor-treated cells contained almost exclusively p55 and other gag precursors, but not p24. Incubation of HIV-like particles recovered from drug-treated cultures in drug-free medium indicated that inhibition of p55 proteolysis was at least partially reversible, suggesting that U-81749 was present within the particles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McQuade, T J -- Tomasselli, A G -- Liu, L -- Karacostas, V -- Moss, B -- Sawyer, T K -- Heinrikson, R L -- Tarpley, W G -- New York, N.Y. -- Science. 1990 Jan 26;247(4941):454-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Infectious Disease Research Unit, Upjohn Company, Kalamazoo, MI 49001.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2405486" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antiviral Agents/*pharmacology ; DNA, Viral/genetics ; Endopeptidases/*metabolism ; Fusion Proteins, gag-pol/genetics/metabolism ; Gene Products, gag/metabolism ; HIV Protease ; HIV-1/*drug effects/genetics/physiology ; Humans ; Lymphocytes/microbiology ; Molecular Sequence Data ; Molecular Structure ; Oligopeptides/*pharmacology ; Protease Inhibitors/*pharmacology ; Protein Precursors/metabolism ; RNA, Viral/metabolism ; Transfection ; Virus Replication/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-04-20
    Description: The role of the immune response to hepatitis B virus (HBV)-encoded antigens in the pathogenesis of liver cell injury has not been defined because of the absence of appropriate experimental models. HBV envelope transgenic mice were used to show that HBV-encoded antigens are expressed at the hepatocyte surface in a form recognizable by major histocompatibility complex (MHC) class I-restricted, CD8+ cytotoxic T lymphocytes specific for a dominant T cell epitope within the major envelope polypeptide and by envelope-specific antibodies. Both interactions led to the death of the hepatocyte in vivo, providing direct evidence that hepatocellular injury in human HBV infection may also be immunologically mediated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moriyama, T -- Guilhot, S -- Klopchin, K -- Moss, B -- Pinkert, C A -- Palmiter, R D -- Brinster, R L -- Kanagawa, O -- Chisari, F V -- CA34635/CA/NCI NIH HHS/ -- CA38635/CA/NCI NIH HHS/ -- CA40489/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1990 Apr 20;248(4953):361-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research Institute of Scripps Clinic, La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1691527" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Line, Transformed ; Cytotoxicity, Immunologic ; Epitopes/immunology ; Hepatitis B/*immunology ; Hepatitis B Surface Antigens/genetics/*immunology ; Histocompatibility Antigens Class I/immunology ; Liver/*immunology ; Mice ; Mice, Transgenic ; Molecular Sequence Data ; Simian virus 40 ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Regulatory/immunology ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Induction of Plasmodium falciparum transmission-blocking antibodies by recombinant vaccinia virus (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-05-31
    Description: Many candidate antigens of malaria vaccines have limited immunological recognition. One exception is Pfs25, a cysteine-rich, 25-kilodalton sexual stage surface protein of Plasmodium falciparum. Pfs25 is a target of monoclonal antibodies that block transmission of malaria from vertebrate host to mosquito vector. The surface of mammalian cells infected with a recombinant vaccinia virus that expressed Pfs25 specifically bound transmission-blocking monoclonal antibodies. Furthermore, major histocompatibility complex-disparate congenic mouse strains immunized with recombinant Pfs25 elicited transmission-blocking antibodies, demonstrating that the capacity to develop transmission-blocking antibodies is not genetically restricted in mice. Live recombinant viruses may provide an inexpensive, easily administered alternative to subunit vaccines prepared from purified recombinant proteins to block transmission of malaria in developing countries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaslow, D C -- Isaacs, S N -- Quakyi, I A -- Gwadz, R W -- Moss, B -- Keister, D B -- New York, N.Y. -- Science. 1991 May 31;252(5010):1310-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Malaria Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1925544" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/analysis/immunology ; Antibodies, Protozoan/*immunology ; Antigens, Protozoan ; Immunization ; Malaria, Falciparum/*prevention & control ; Mice ; Plasmodium falciparum/*immunology ; Protozoan Proteins/genetics/*immunology ; Recombinant Proteins/immunology ; Transfection ; Vaccinia virus/genetics/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Inhibition of the complement cascade by the major secretory protein of vaccinia virus (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-11-09
    Description: The complement system contributes to host defenses against invasion by infectious agents. A 35-kilodalton protein, encoded by vaccinia virus and secreted from infected cells, has sequence similarities to members of a gene family that includes complement control proteins. Biochemical and genetic studies showed that the viral protein binds to derivatives of the fourth component of complement and inhibits the classical complement cascade, suggesting that it serves as a defense molecule to help the virus evade the consequences of complement activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kotwal, G J -- Isaacs, S N -- McKenzie, R -- Frank, M M -- Moss, B -- New York, N.Y. -- Science. 1990 Nov 9;250(4982):827-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2237434" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Chromatography, Gel ; Complement C4b/*metabolism ; *Complement Pathway, Classical ; Hemolytic Plaque Technique ; Immunoblotting ; Molecular Sequence Data ; Restriction Mapping ; Vaccinia virus/genetics/*immunology ; Viral Proteins/*genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Why the smallpox virus stocks should not be destroyed (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-11-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Joklik, W K -- Moss, B -- Fields, B N -- Bishop, D H -- Sandakhchiev, L S -- New York, N.Y. -- Science. 1993 Nov 19;262(5137):1225-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Duke University Medical Center, Durham, NC 27710.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8235652" target="_blank"〉PubMed〈/a〉
    Keywords: *Biological Specimen Banks ; Centers for Disease Control and Prevention (U.S.) ; *Containment of Biohazards ; Genome, Viral ; Humans ; Preservation, Biological ; Smallpox/*prevention & control ; United States ; *Variola virus/genetics ; World Health Organization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
    Electronic Resource
    Electronic Resource
    Regulation of Vaccinia Virus Transcription (1990)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 59 (1990), S. 661-688 
    Details
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bi.59.070190.003305
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  • 8
    Electronic Resource
    Electronic Resource
    New mammalian expression vectors (1990)
    [s.l.] : Nature Publishing Group
    Nature 348 (1990), S. 91-92 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE high transcriptase activity, stringent promoter specificity, excellent processi-vity, and single-subunit structure of the RNA polymerases from T7 and related bacteriophages have made these enzymes the basis for prokaryotic expression vector systems. Use of prokaryotic RNA polymerases for ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/348091a0
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  • 9
    Electronic Resource
    Electronic Resource
    Long-term responses to fish-stock reduction in small shallow lakes: interpretation of five-year results of four biomanipulation cases in The Netherlands and Denmark (1994)
    Springer
    Hydrobiologia 275-276 (1994), S. 457-466 
    Details
    ISSN: 1573-5117
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The effects of fish stock reduction have been studies in 3 Dutch lakes (Lake Zwemlust, Lake Bleiswijkse Zoom and Lake Noorddiep) and 1 Danish lake (Lake Væng) during 4–5 years. A general response id described. The fish stock reduction led in general to a low fish stock, low chlorophyii-a, high transparency and high abunuance of macrophytes. Large Daphnia became abundant, but their density decreased, due to food limitation and predation by fish. The total nitrogen concentration became low due to N-uptake by macrophytes and enhanced denitrification. In Lake Bleiswijkse Zoom the water transparency deteriorated and the clear water state was not stable. The fish stock increased and the production of young fish in summer was high. lear water occurred only in spring. Large daphnids were absent in summer and the macrophytes decreased. In Lake Zwemlust, Lake Væng and Lake Noorddiep the water remained clear during the first five years. In summer of the sixth year (1992) transparency decreased in Lake Zwemlust (with high P-concentration of 1.0 mg P l-1). Also in Lake Væng (with a low nutrient concentration of 0.15 mg P.⋆-1) a short term turbid stage (1.5 month) occurred in summer 1992 after a sudden collapse of the macrophytes. Deterioration of the water quality seems to start in summer and seems related to a collapse in macrophytes. At a low planktivorous fishstock (e.g. Lake Væng)thhe duration of the turbid state is shorter. than in presence of a high planktivorous fish biomass (e.g. Lake Zwemlust, and later years of Lake Bleiswijkse Zoom).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00026734
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  • 10
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    An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection. (1990)
    National Academy of Sciences
    Details
    Publication Date: 1990-10-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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