ISSN:
1432-1041
Keywords:
5-Aminosalicylic acid
;
Faecal bacteria
;
Sulphasalazine
;
acetyl-5-aminosalicylic acid
;
drug metabolism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary After oral administration of 5-aminosalicylic acid a substantial proportion of the acetylated form is excreted in the faeces. We have studied the role of the faecal microflora in acetylating 5-aminosalicylic acid. In faeces incubated under both aerobic and anaerobic conditions there was acetylation of 5-aminosalicylic acid. Of the anaerobic bacteria isolated from a 108 faecal dilution 44% were able to acetylate 5-aminosalicylic acid. We conclude that the normal faecal microflora contribute to the acetylation of 5-aminosalicylic acid.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01740669
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