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  • 1
    Electronic Resource
    Electronic Resource
    Metabolic chiral inversion of ibuprofen in isolated rat hepatocytes (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 2 (1990), S. 74-78 
    Details
    ISSN: 0899-0042
    Keywords: ibuprofen ; in vitro metabolism ; chiral inversion ; rat hepatocytes ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Ibuprofen was used to demonstrate that isolated rat hepatocytes offer a suitable in vitro model to investigate the metabolic chiral inversion of anti-inflammatory 2-arylpropionic acids (profens). The inversion of the pharmacologically inactive (-)-(R)-ibuprofen to the active (+)-(S)-ibuprofen was shown to obey apparent first-order kinetics during 5 h and to increase linearly with increasing hepatocyte concentration up to 4 × 105 cells/ml. No elimination of (R)-ibuprofen by routes other than inversion was seen, whereas the elimination of (S)-ibuprofen appeared to be saturable.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530020203
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  • 2
    Electronic Resource
    Electronic Resource
    Preparative and analytical separation of the zopiclone enantiomers and determination of their affinity to the benzodiazepine receptor binding site (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 5 (1993), S. 419-421 
    Details
    ISSN: 0899-0042
    Keywords: zopiclone ; chiral liquid chromatography ; enantioseparation ; fractional crystallization ; cyclopyrrolone ; benzodiazepine receptor binding ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We report the preparative separation of rac-zopiclone using malic acid as the resolving agent. Furthermore, two different methods for the analytical determination of zopiclone enantiomers by HPLC on chiral stationary phases are described. The benzodiazepine receptor binding of the isolated enantiomers was investigated. Half-maximal inhibitory concentrations of (+)- and (-)-zopiclone were 21 or 1,130 nmol/liter, respectively, indicating a more than 50 times higher affinity of the (+)-enantiomer toward the receptor. © 1993 Wiley-Liss, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530050605
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  • 3
    Electronic Resource
    Electronic Resource
    Solvation of indenyllithium and indenylpotassium studied by 13C NMR spectroscopy (1990)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 3 (1990), S. 9-12 
    Details
    ISSN: 0894-3230
    Keywords: Organic Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Polarization of the π-electron systems of indenyllithium (In -Li+) and indenylpotassium (In -K+), which is generally indicative of the degree and tightness of contact ion pairing, was investigated by 13C NMR spectroscopy. The effect of changing solvent is about two thirds as great for In -K+ as for In -Li+. The indenyl anion is more strongly polarized with Li+/dimethyl sulfoxide than with Li+/ammonia, whereas the reverse is observed for In -K+. Complexation of In -K+ in tetrahydrofuran (THF) by cryptand(2,2,2) results in a π-electron distribution identical with that of In -Li+ in hexamethylphosphoramide, indicative of solvent- or agent-separated ion pairs or free ions. Small but significant cation-anion interactions are observed for In -K+ in hexamethylphosphoramide and for In -N+Me4 in THF.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/poc.610030103
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  • 4
    Electronic Resource
    Electronic Resource
    Phosphonic systems. Part 8. Solution and solid-state conformation of diastereomeric adducts of diethyl prop-2-enylphosphonate to p-nitrobenzaldehyde (1993)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 6 (1993), S. 64-70 
    Details
    ISSN: 0894-3230
    Keywords: Organic Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A mixture of siastereomeric adducts of lithiated diethyl prop-2-enylphosphonate to p-nitrobenzaldehyde was separated and the solution and the solid-state structures of the individual stereoisomers were studied. Conformational analysis demonstrated that in solution the most populated rotamer involves in both cases trans orientation of the PO3Et2 and O2NC6H4 groups and a gauche relationship of the phosphoryl and hydroxyl groups. In the solid state the crystal structure determination demonstrated that the molecules exist in the same conformation as in solution, although the P=O⃛H—O hydrogen bonding changed from intramolecular to intermolecular (dimeric) interactions.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/poc.610060111
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  • 5
    Electronic Resource
    Electronic Resource
    Photoinitiierte Polymerisation mit Dialkoxythiocarbonyldisulfiden - eine Polymerisationsreaktion mit PrimärradikalabbruchLichtinitiierte Polymer- und Polymerisationsreaktionen 37. Mitt.; 36. Mitt.: U. Müller, H.-J. Timpe, K.-G. Häussler, K. Peters, R. Wagner: Acta Polym. 41 (1990) 54. (1990)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 332 (1990), S. 1013-1028 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Photoinitiated Polymerization with Dialkoxy Thiocarbonyl Disulfides - a Polymerization Reaction with Primary Radical TerminationThe photoinduced free radical polymerization of methyl methacrylate (MMA) and some other vinyl monomers using dialkoxy thiocarbonyl disulfides (1-4) as photoinitiators was studied. The photolysis of these initiators leads to cleavage of the S—S bond, which was determined by spin trapping experiments with phenyl tert-butyl nitrone. No evidence was found for a further thermal decomposition of the primary alkoxy thiocarbonyl sulfide radicals (R·) at room temperature. In the absence of scavengers the primary radicals react back exclusively to the initial compounds, due to a strong cage effect. By means of UV spectroscopic measurements and in the presence of MMA the quantum yields of the initiator decomposition were detected to be 0.8. The polymerization of acrylic and methacrylic derivatives can be initiated by the R·, contrary to the situation with fumarates and maleates. The mechanism of MMA polymerization depends on the light intensity absorbed by the initiators. At high intensities the combination of primary and polymer radicals terminates the chain reaction. This follows from the measured monomer exponent of α = 2, the light intensity exponent of β = 0,2 and the number of thiocarbonyl end groups of 2 in the polymers isolated. Contrary to this, in the low intensity region the experimental data obey the ideal kinetic equation. Kinetic modelling gives evidence for an interaction of the monomer with the cage radicals.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19903320619
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  • 6
    Electronic Resource
    Electronic Resource
    Synthese von Pyrazolo[3,4-b]chinolinen aus 4-Aroyl-5-chlor-pyrazolen (1990)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 332 (1990), S. 693-698 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthesis of Pyrazolo[3,4-b]quinolines from 4-Aroyl-5-chloropyrazolesThe reaction of 4-aroyl-5-chloro-3-methyl-1-phenyl-pyrazoles 1 with an excess of 3- or 4-substituted and 3,4-disubstituted anilines 2 gives pyrazolo [3,4-b]quinolines 4a-k. Information about the reaction mechanism was obtained by the isolation of the intermediate product 3e. In some cases it was possible to isolate subsequent products 41-p. The reaction of 1a with 5-amino-3-methyl-1-phenyl-pyrazole (5) gives a bispyrazolopyridine derivative 6.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19903320518
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  • 7
    Electronic Resource
    Electronic Resource
    Synthese und Charakterisierung von Bisphenyl- und Biscyclohexyl-4,4′-bibenzyldicarboxylaten (1993)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 335 (1993), S. 316-320 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Syntheses and Characterisation of Bisphenyl- and Biscyclohexyl-4,4′-bibenzyldicarboxylatesA one pot syntheses gives bisphenyl-4,4′-bibenzyldicarboxylates (2) or biscyclohexyl-4,4′-bibenzyldicarboxylates (3) from bibenzyl (4) and phenols (5) or cyclohexanols (6). 20 compounds 2 and 3 with substituents in the p-position of the peripheric rings have been synthesized; liquid crystalline data are given.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19933350403
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  • 8
    Electronic Resource
    Electronic Resource
    Photovernetzung von Siliconen. VII. Zum Einfluß der Siliconkette - eine kinetische StudieHerrn Prof. Dr. Dr. H. G. O. Becker zum 70. Geburtstag gewidmet (1992)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 334 (1992), S. 603-610 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Photocrosslinking of Silicones. VII. The Influence of the Silicone Backbone - a Kinetic StudyThe photo-induced radical crosslinking of silicone containing pendant acrylate groups was investigated by nanosecond flash photolysis and photocalorimetry. From the results of the flash photolysis is inferred that the photochemically formed benzoyl radicals react with the acrylate groups of the system. A possible H-abstraction from the methyl groups of the silicone backbone was not observed. The silicone backbone functions only as an internal solvent. Calorimetric measurements with model systems support these results.The polymerization process is inhibited by oxygen. From calorimetric results is inferred that oxygen both inhibits and terminates the polymerization process. Due to their high oxygen solubility the silicone units increase the oxygen influence on the crosslinking.The calorimetric measurements shows also that a direct bond between silicone backbone and the acrylate group reduces the oxygen influence. Also, in absence of oxygen a direct bonded acrylate group accelerates the polymerization rate.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19923340710
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  • 9
    Electronic Resource
    Electronic Resource
    Spektroskopische Untersuchungen an Naphtho[1,2-d]thiazolen. II. Bandenanalyse der Absorptions- und Fluoreszenzspektren von 2-Aryl-naphtho[1,2-d]thiazolen (1992)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 334 (1992), S. 619-624 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Spectroscopic Investigations on Naphtho[1.2-d]thiazoles. II. Deconvolution of Absorption and Fluorescence Spectra of 2-Aryl-naphtho[1.2-d]thiazolesFluorescence measurements were carried out of organic fluorescent compounds of the type of 2-aryl-naphtho[1.2-d]thiazoles (1a-k) substituted in the aryl group by different electronic donor and acceptor substituents. 2-Phenyl-naphtho[1.2-d]thiazole was used in the series of these compounds as the reference system for optical properties. A scheme of vibronic terms in ground and excited states resulting from the spectra of emission, ultraviolet absorption and excitation is given.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19923340712
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  • 10
    Electronic Resource
    Electronic Resource
    Flüssigkristalle mit aliphatischen Gruppen zwischen Cyclohexanringen - Synthesen von 1,4-Bis-(4-n-alkylcyclohexyl)butanen und 4-[4-4(4-n-Alkylcyclohexyl)butyl]cyclohexylestern (1992)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 334 (1992), S. 625-629 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Liquid Crystals with Aliphatic Groups between Cyclohexane Rings - Synthesis of 1,4-Bis(4-n-alkylcyclohexyl)butanes and Esters of 4-[4-(4-n-Alkylcyclohexyl)-butyl]cyclohexanolsThe synthesis of 1,4-bis-(4-n-alkylcyclohexyl) butanes (1), esters of 4-[-(4-n-alkylcyclohexyl)butyl]cyclohexanols (2) and some analogous aromatic compounds are described. The thermal stability of mesophases of these compounds are in the order of the analogous ethylene-bridged liquid crystals. The reason for this result seems to be the combination of molecular rigidity and conformational flexibility.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19923340713
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