Publication Date:
1992-07-27
Description:
Lethargic (lh/lh) mice, which function as an animal model of absence seizures, have spontaneous seizures that have behavioral and electrographic features and anticonvulsant sensitivity similar to those of human absence seizures. Antagonists of the gamma-aminobutyric acidB (GABAB) receptor suppressed these seizures in lethargic mice, whereas agonists of GABAB receptors exacerbated them. Furthermore, GABAB receptor binding and synaptically evoked GABAB receptor-mediated inhibition of N-methyl-D-aspartate responses were selectively increased in lh/lh mice. Therefore, enhanced GABAB receptor-mediated synaptic responses may underlie absence seizures in lh/lh mice, and GABAB receptor antagonists hold promise as anticonvulsants for absence seizures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hosford, D A -- Clark, S -- Cao, Z -- Wilson, W A Jr -- Lin, F H -- Morrisett, R A -- Huin, A -- New York, N.Y. -- Science. 1992 Jul 17;257(5068):398-401.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Duke University, Durham, NC.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1321503" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anticonvulsants/pharmacology
;
Baclofen/analogs & derivatives/pharmacology
;
Disease Models, Animal
;
Dose-Response Relationship, Drug
;
Electroencephalography
;
Electrophysiology
;
Epilepsy, Absence/drug therapy/*physiopathology
;
Hippocampus/drug effects/physiology
;
In Vitro Techniques
;
Mice
;
Mice, Inbred Strains
;
Organophosphorus Compounds/pharmacology
;
Picrotoxin/pharmacology
;
Quinoxalines/pharmacology
;
Receptors, GABA-A/*physiology
;
Receptors, N-Methyl-D-Aspartate/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink