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  • 1
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    Genes for epilepsy mapped in the mouse (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-08-09
    Description: The neurological mutant mouse strain E1 is a model for complex partial seizures in humans. The inheritance of epileptic seizures with seven conventional chromosomal markers and over 60 endogenous proviral markers was studied by means of back-crosses of E1 with two seizure-resistant strains, DBA/2J and ABP/LeJ. The major gene responsible for this epileptic phenotype (El-1) was localized to a region distal with respect to the centromere on chromosome 9. At least one other gene, El-2, linked to proviral markers on chromosome 2, also influences the seizure phenotype. In addition, a potential modifier of seizures was detected in the DBA/2J background. The location of El-1 on distal chromosome 9 may allow identification of an epilepsy candidate gene in humans on the basis of conserved synteny with human chromosome 3.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rise, M L -- Frankel, W N -- Coffin, J M -- Seyfried, T N -- NS 23355/NS/NINDS NIH HHS/ -- R35CA44385/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1991 Aug 9;253(5020):669-73.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Boston College, Chestnut Hill 02167.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1871601" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; Crosses, Genetic ; Epilepsy/*genetics ; Female ; Genetic Predisposition to Disease ; Male ; Mice ; Mice, Inbred Strains ; Mice, Neurologic Mutants/*genetics ; Recombination, Genetic ; Seizures/genetics ; Software
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Long-term high-titer neutralizing activity induced by octameric synthetic HIV-1 antigen (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-10-11
    Description: A titer for homologous viral neutralization activity (greater than 1:19,683) was observed after a 3.5-year immunization period with an octameric, branching peptide representing the principal neutralizing determinant (PND) of the human immunodeficiency virus-1IIIB envelope protein. Booster immunizations elicited persistent and potent antibodies in guinea pigs, exceeding responses produced by a conventional bovine serum albumin conjugate by 100-fold. Peptide length, central presentation of a conserved sequence, and inclusion of an upstream sequence contributed to immunogenicity. Titers (greater than 1:1,000) of heterotypic neutralizing antibodies also developed. Octameric PND peptides are a promising approach for an acquired immunodeficiency syndrome (AIDS) vaccine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, C Y -- Looney, D J -- Li, M L -- Walfield, A M -- Ye, J -- Hosein, B -- Tam, J P -- Wong-Staal, F -- IU01-AI-30238/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1991 Oct 11;254(5029):285-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉United Biomedical, Inc., Lake Success, NY 11042.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1925584" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/genetics/*immunology ; Amino Acid Sequence ; Animals ; Female ; Guinea Pigs ; HIV Antigens/genetics/*immunology ; HIV-1/*immunology ; Molecular Sequence Data ; Neutralization Tests ; Vaccines, Synthetic/genetics/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-09-09
    Description: The gene aquaporin-1 encodes channel-forming integral protein (CHIP), a member of a large family of water transporters found throughout nature. Three rare individuals were identified who do not express CHIP-associated Colton blood group antigens and whose red cells exhibit low osmotic water permeabilities. Genomic DNA analyses demonstrated that two individuals were homozygous for different nonsense mutations (exon deletion or frameshift), and the third had a missense mutation encoding a nonfunctioning CHIP molecule. Surprisingly, none of the three suffers any apparent clinical consequence, which raises questions about the physiological importance of CHIP and implies that other mechanisms may compensate for its absence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Preston, G M -- Smith, B L -- Zeidel, M L -- Moulds, J J -- Agre, P -- DK32753/DK/NIDDK NIH HHS/ -- HL33991/HL/NHLBI NIH HHS/ -- HL48268/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1994 Sep 9;265(5178):1585-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7521540" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aquaporin 1 ; *Aquaporins ; Base Sequence ; Blood Group Antigens ; Cell Membrane Permeability ; Erythrocyte Membrane/chemistry/physiology ; Exons ; Female ; Homozygote ; Humans ; Ion Channels/blood/*genetics/urine ; Kidney Tubules/chemistry ; Molecular Sequence Data ; Mutation ; Oocytes ; Phenotype ; Polymerase Chain Reaction ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Saltation and stasis: a model of human growth (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-10-30
    Description: Human growth has been viewed as a continuous process characterized by changing velocity with age. Serial length measurements of normal infants were assessed weekly (n = 10), semiweekly (n = 18), and daily (n = 3) (19 females and 12 males) during their first 21 months. Data show that growth in length occurs by discontinuous, aperiodic saltatory spurts. These bursts were 0.5 to 2.5 centimeters in amplitude during intervals separated by no measurable growth (2 to 63 days duration). These data suggest that 90 to 95 percent of normal development during infancy is growth-free and length accretion is a distinctly saltatory process of incremental bursts punctuating background stasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lampl, M -- Veldhuis, J D -- Johnson, M L -- DK 38942/DK/NIDDK NIH HHS/ -- KO4HD00634/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1992 Oct 30;258(5083):801-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology, University of Pennsylvania, Philadelphia 19104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1439787" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Body Height ; Cephalometry ; Female ; *Growth ; Head/growth & development ; Humans ; Infant ; Infant, Newborn ; Kinetics ; Male ; *Models, Biological
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Source characteristics of Jovian narrow-band kilometric radio emissions (1993)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: New observations of Jovian narrow-band kilometric (nKOM) radio emissions were made by the Unified Radio and Plasma Wave (URAP) experiment on the Ulysses spacecraft during the Ulysses-Jupiter encounter in early February 1992. These observations have demonstrated the unique capability of the URAP instrument for determining both the direction and polarization of nKOM radio sources. An important result is the discovery that nKOM radio emission originates from a number of distinct sources located at different Jovian longitudes and at the inner and outermost regions of the Io plasma torus. These sources have been tracked for several Jovian rotations, yielding their corotational lags, their spatial and temporal evolution, and their radiation characteristics at both low latitudes far from Jupiter and at high latitudes near the planet. Both right-hand and left-hand circularly polarized nKOM sources were observed. The polarizations observed for sources in the outermost regions of the torus seem to favor extraordinary mode emission.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); 98; E7; p. 13,163-13,176.
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  • 6
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    Ulysses observations of escaping VLF emissions from Jupiter (1992)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The Ulysses URAP experiment has detected Jovian radio emissions in the VLF range at distances from Jupiter in excess of 1.5 AU. The URAP observations represent the first synoptic observations of Jupiter in the VLF band, from 3 to 30 kHz. In this band lie the low-frequency extent of the bKOM emission, the escaping continuum emission, and the Jovian type IIIs. Initial results indicate that the continuum varies in frequency with the solar wind ram pressure at Jupiter, whereas, the Jovian type IIIs appear to be controlled to some extent by the planetary rotation, often appearing when system III longitude 100 deg faces the spacecraft.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Geophysical Research Letters (ISSN 0094-8276); 19; 649-652
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  • 7
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    In ecliptic observations of Jovian radio emissions by Ulysses - Comparison with Voyager results (1992)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: During the Ulysses inbound cruise to Jupiter the Unified Radio and Plasma Wave (URAP) experiment observed a variety of the planet's radio components in the frequency range below 1 MHz. Most of these emissions were already detected by the Voyager Radio Astronomy and Plasma Wave experiments, however, with much less sensitivity and different spectral coverage. These different radio components within the URAP dynamic spectra are identified, and their appearance with the previous Voyager observations are compared.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Geophysical Research Letters (ISSN 0094-8276); 19; 12, J; 1307-131
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  • 8
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    Phenomenology of Neptune's radio emissions observed by the Voyager planetary radio astronomy experiment (1992)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The Neptune flyby in 1989 added a new planet to the known number of magnetized planets generating nonthermal radio emissions. We review the Neptunian radio emission morphology as observed by the planetary radio astronomy experiment on board Voyager 2 during a few weeks before and after closest approach. We present the characteristics of the two observed recurrent main components of the Neptunian kilometric radiation, i.e., the 'smooth' and the 'bursty' emissions, and we describe the many specific features of the radio spectrum during closest approach.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); 97; A12; p. 19,201-19,211.
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  • 9
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    Time-variable magnetospheric radio emissions from Jupiter (1993)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Jupiter is the source of a large number of independent nonthermal radio sources, all of which vary with time. The known causes of the variations include planetary rotation modulation, modulation by Io and/or its torus, and influence by the solar wind which can reach suprisingly deep into the Jovian magnetosphere. However, a significant number of radio variations, both short-term and long-term, are not currently explained by any known mechanism.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research (ISSN 0148-0227); 98; E10; p. 18,757-18,765
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  • 10
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    Uranus as a radio source (1991)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The complex nature of the Uranus radio emissions, both magnetospheric and atmospheric, is reviewed, with emphasis on the identification of distinct components and the determination of their source locations. Seven radii components were discovered in addition to the RF signature of lightning in the planet's atmosphere. Six of the seven magnetospheric components are freely propagating emissions; one component, the nonthermal continuum, is trapped in the density cavity between the magnetopause and the dense inner magnetosphere. The radio components are divided into two types according to their emission signature: bursty emission and smooth emission. The inferred source location for the dominant nightside emission is above the nightside magnetic pole, largely overlapping the UV auroral region and the magnetic polar cap. The N-burst component appears to be associated with solar-wind enhancements at Uranus, consistent with the idea that the solar wind was triggering magnetospheric substormlike activity during the encounter.
    Keywords: LUNAR AND PLANETARY EXPLORATION
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