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  • Engineering  (1)
  • Periplaneta americana  (1)
  • Polymer and Materials Science  (1)
  • Models, Biological
  • 1990-1994  (3)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of comparative physiology 172 (1993), S. 359-368 
    ISSN: 1432-1351
    Keywords: Acetylcholine receptors ; Muscarinic ; Nicotinic ; Cockroach ; Periplaneta americana
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of a number of cholinergic agonists and antagonists have been examined on the cell body of the fast coxal depressor (Df) of the cockroach Periplaneta americana using voltage-clamp techniques. Acetylcholine (ACh), when applied to this neurone voltage-clamped at its normal resting potential, results in the generation of an inward current through the activation of receptors which are blocked by α-bungarotoxin (α-bgt). At more depolarized membrane potentials acetylcholine induces an inward current which is strongly voltage-dependent and which is insensitive to α-bgt. An α-bgt-resistant current is also induced by the application of a number of cholinergic agonists. In order of potency these are: decamethonium〉oxotremorine = McN-A-343 = (+)-muscarine = arecaidine propargyl ester 〉nicotine 〉ACh. This α-bgt-resistant response to cholinergic agonists is blocked by a range of antagonists. In order of potency these are : decamethonium 〉pirenzipine 〉quinuclidinyl benzilate = atropine = p-f-hexahydro-sila-difenidol = dexetimide 〉scopolamine = methoctramine. The receptors mediating this response have been termed ‘mixed cholinergic’ due to their sensitivity to both nicotinic and muscarinic ligands. Pharmacological similarities between these ‘mixed’ receptors and binding components found in high speed supernatant fractions of insect nervous tissue are discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Adhesion formation associated with tendon surgery is a widespread problem in which a healing tendon becomes adherent via scar tissue to surrounding structures such as bone, muscle, skin, tendon sheath, or other tendons. A model is described in which adhesions were generated reproducibly between the plantaris and Achilles tendons of the rabbit using a partial tenotomy, a Bunnel suture, and immobilization. Using this model, the effect of an absorbable barrier, INTERCEED (TC7),INTERCEED (TC7) Absorbable Adhesion Barrier is a trademark of Johnson & Johnson Patient Care Inc. on adhesion formation was investigated. This material, which is a fabric comprised of oxidized regenerated cellulose, was found to diminish significantly the extent and severity of intertendinous adhesions, assessed both mechanically and histologically. No evidence of a foreign body reaction was observed.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 17 (1993), S. 385-400 
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The equations governing the elastic-plastic deformation of granular materials are typically hyperbolic, or contain small-magnitude damping or rate effects. A finite element algorithm is the standard method for the numerical integration of these systems. In particular, finite elements allow great flexibility in the design of grid geometry. However, modern finite difference methods for hyperbolic systems have been successful in aerodynamics computations, resolving wave structures more sharply than finite element schemes. In this paper we develop a finite difference scheme for granular flow problems. We report on a second-order Godunov-type scheme for the integration of hyperbolic equations for the elastoplastic deformation of a simple model of granular flow. The Godunov method includes a characteristic tracing step in the integration, providing minimal wave dispersion, and a slope limiting step, preventing unphysical oscillations.The granular flow model we consider is hyperbolic, but hyperbolicity is lost at a large value of accumulated plastic strain. This loss of hyperbolicity is a tell-tale signal for the formation of a shear band within the sample. Typically, when systems lose hyperbolicity a regularization mechanism is added to the model equations in order to maintain the well posedness of the system. These regularizations include viscosity, viscoplasticity, higher-order gradient effects or stress coupling. Here we appeal to a very different kind of regularization. When the system loses hyperbolicity and a shear band forms, we treat the band as an internal boundary, and impose jump conditions at this boundary. Away from the band, the system remains hyperbolic and the integration step proceeds as usual.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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