Publication Date:
1990-07-20
Description:
Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-gamma 1 (PLC-gamma 1) from a predominantly cytosolic localization to membrane fractions. The temporal coincidence of this redistribution with EGF stimulation of inositol phosphate formation and EGF increased phosphorylation of PLC-gamma 1 suggests that the membrane association of PLC-gamma 1 is a significant event in second messenger transduction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Todderud, G -- Wahl, M I -- Rhee, S G -- Carpenter, G -- CA24071/CA/NCI NIH HHS/ -- GM07347/GM/NIGMS NIH HHS/ -- T32 AM07491/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1990 Jul 20;249(4966):296-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2374928" target="_blank"〉PubMed〈/a〉
Keywords:
Carcinoma, Squamous Cell
;
Cell Line
;
Cell Membrane/drug effects/enzymology
;
Cytosol/enzymology
;
Epidermal Growth Factor/*pharmacology
;
Humans
;
Isoenzymes/*metabolism
;
Kinetics
;
Phosphopeptides/isolation & purification
;
Protein Binding
;
Trypsin
;
Type C Phospholipases/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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