Publikationsdatum:
1992-04-17
Beschreibung:
Chlamydial cell types are adapted for either extracellular survival or intracellular growth. In the transcriptionally inert elementary bodies, the chromosome is densely compacted; in metabolically active reticulate bodies, the chromatin is loosely organized. Condensation of the chlamydial nucleoid occurs concomitant with expression of proteins homologous to eukaryotic histone H1. When the Chlamydia trachomatis 18-kilodalton histone homolog Hc1 is expressed in Escherichia coli, a condensed nucleoid structure similar to that of chlamydiae is observed with both light and electron microscopy. These results support a role for Hc1 in condensation of the chlamydial nucleoid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barry, C E 3rd -- Hayes, S F -- Hackstadt, T -- New York, N.Y. -- Science. 1992 Apr 17;256(5055):377-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Host-Parasite Interaction Unit, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1566085" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Blotting, Western
;
Cell Nucleus/*ultrastructure
;
Centrifugation, Density Gradient
;
Chlamydia trachomatis/*genetics/ultrastructure
;
Chromatin/ultrastructure
;
DNA/metabolism
;
Deoxyribonuclease I
;
Escherichia coli/genetics/*ultrastructure
;
*Gene Expression
;
Histones/*genetics/metabolism/physiology
;
Microscopy, Immunoelectron
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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