ISSN:
0749-1581
Keywords:
Alphitonia zizyphoides
;
Saponin
;
2D NMR
;
INADEQUATE
;
Molecular structure
;
Computerized spectral analysis
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
High-field NMR experiments, including the 2D INADEQUATE technique coupled with a computerized spectral analysis, were used to determine the full structure of a new saponin extracted from a plant (Alphitonia zizyphoides) found in the Samoan rain forests. The saponin, which shows significant pharmacological activity, consists of an aglycone framework of six rings (three saturated six-membered rings, two oxygen-containing five-membered rings and a five-membered carbon ring) to which are attached four sugar units and a six-carbon side-chain. The INADEQUATE experiment, which was carried out on 60 mg of sample, provided absolute confirmation of the assignments for 35 of the possible 53 C—C bonds from the 13C-13C connectivities.
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260310511
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