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  • ASTROPHYSICS  (30)
  • COMPUTER PROGRAMMING AND SOFTWARE  (7)
  • Animals  (5)
  • 1990-1994  (42)
  • 1
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    GABAergic pathway from zona incerta to neocortex: clarification (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-03-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, C S -- Nicolelis, M A -- Schneider, J S -- Chapin, J K Jr -- New York, N.Y. -- Science. 1991 Mar 8;251(4998):1162.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1706534" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axonal Transport ; Cerebral Cortex/*anatomy & histology ; Diencephalon/*anatomy & histology ; Horseradish Peroxidase ; Mice ; Neurons/cytology ; Rats ; Thalamus/*anatomy & histology ; gamma-Aminobutyric Acid/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Recovery from experimental parkinsonism in primates with GM1 ganglioside treatment (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-05-08
    Description: A parkinsonian syndrome can be produced in nonhuman primates by administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Parkinsonian-like symptoms induced acutely by MPTP were ameliorated after treatment with GM1 ganglioside, a substance shown to have neurotrophic effects on the damaged dopamine system in rodents. Treatment with GM1 ganglioside also increased striatal dopamine and metabolite levels and enhanced the dopaminergic innervation of the striatum as demonstrated by tyrosine hydroxylase immunohistochemistry. These results suggest that GM1 ganglioside may hold promise as a therapeutic agent for the treatment of Parkinson's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schneider, J S -- Pope, A -- Simpson, K -- Taggart, J -- Smith, M G -- DiStefano, L -- New York, N.Y. -- Science. 1992 May 8;256(5058):843-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Hahnemann University, School of Medicine, Philadelphia, PA 19102.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1350379" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology ; 3,4-Dihydroxyphenylacetic Acid/metabolism ; Animals ; Corpus Striatum/drug effects/*metabolism ; Dopamine/*metabolism ; G(M1) Ganglioside/*therapeutic use ; Homovanillic Acid/metabolism ; Immunohistochemistry ; Macaca fascicularis ; *Motor Activity/drug effects ; Parkinson Disease, Secondary/chemically induced/*drug therapy/metabolism ; Putamen/drug effects/metabolism ; Reference Values ; Saimiri ; Tyrosine 3-Monooxygenase/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    A major direct GABAergic pathway from zona incerta to neocortex (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-06-22
    Description: Retrograde fluorescent tracers were used to demonstrate a previously unknown but sizable direct gamma-aminobutyric acid (GABA)-containing neuronal pathway from the zona incerta to the neocortex in rats. This incertocortical pathway was found to project bilaterally to the entire neocortex and exhibited a rough corticotopic organization. Many of the zona incerta neurons projecting to the parietal and occipital cortices could also be immunohistochemically stained with antibodies to glutamic acid decarboxylase and GABA. Few of these neurons were immunoreactive to tyrosine hydroxylase antibodies, which identify dopamine-containing neurons. Injections in the frontal and entorhinal cortices labeled many neurons near or within the dopaminergic A13 subdivision of the zona incerta. In addition, the incertocortical system was found to be significantly larger during early postnatal (2 to 3 weeks) development. The projection pattern of this newly discovered pathway resembles that of the monoaminergic and cholinergic systems, arising from the brainstem and forebrain, suggesting possible similarities of function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, C S -- Nicolelis, M A -- Schneider, J S -- Chapin, J K -- AA 06965/AA/NIAAA NIH HHS/ -- KO2-AA 00089/AA/NIAAA NIH HHS/ -- NS 26722/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1990 Jun 22;248(4962):1553-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology and Biophysics, Hahnemann University, Philadelphia, PA 19102.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2360049" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/analysis/enzymology/*physiology ; Diencephalon/analysis/enzymology/*physiology ; Dopamine/analysis ; Glutamate Decarboxylase/analysis ; Immunohistochemistry ; Neural Pathways/physiology ; Neurons/analysis/enzymology/*physiology ; Rats ; gamma-Aminobutyric Acid/analysis/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-11-18
    Description: Muscle enhancer factor-2A (MEF2A), a member of the MADS family, induced myogenic development when ectopically expressed in clones of nonmuscle cells of human clones, a function previously limited to the muscle basic helix-loop-helix (bHLH) proteins. During myogenesis, MEF2A and bHLH proteins cooperatively activate skeletal muscle genes and physically interact through the MADS domain of MEF2A and the three myogenic amino acids of the muscle bHLH proteins. Thus, skeletal myogenesis is mediated by two distinct families of mutually inducible and interactive muscle transcription factors, either of which can initiate the developmental cascade.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaushal, S -- Schneider, J W -- Nadal-Ginard, B -- Mahdavi, V -- New York, N.Y. -- Science. 1994 Nov 18;266(5188):1236-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7973707" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Binding Sites ; Cell Differentiation ; Cell Line ; DNA/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; *Gene Expression Regulation ; Genes, Reporter ; Haplorhini ; Helix-Loop-Helix Motifs ; Humans ; MADS Domain Proteins ; MEF2 Transcription Factors ; Mice ; Molecular Sequence Data ; Muscle, Skeletal/*cytology/metabolism ; MyoD Protein/biosynthesis/*metabolism ; Myogenic Regulatory Factors ; Myogenin/biosynthesis/genetics/metabolism ; Transcription Factors/genetics/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-06-03
    Description: The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb-/-) were induced by serum to re-enter the cell cycle. Development of the myogenic phenotype in Rb-/- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-/- myotubes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schneider, J W -- Gu, W -- Zhu, L -- Mahdavi, V -- Nadal-Ginard, B -- New York, N.Y. -- Science. 1994 Jun 3;264(5164):1467-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8197461" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood ; Cell Cycle ; Cell Differentiation ; Cell Line ; Culture Media ; Gene Expression ; Helix-Loop-Helix Motifs ; Humans ; Mice ; Muscles/*cytology/metabolism ; Myogenin/metabolism ; *Nuclear Proteins ; Proteins/genetics/*physiology ; Recombinant Fusion Proteins/metabolism ; Retinoblastoma Protein/genetics/*physiology ; Retinoblastoma-Like Protein p107 ; Transcriptional Activation ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Lessons learned in the development of the Hubble Space Telescope software (1991)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: An effort is made to document what was successful in the HST software development, and to present a retrospective analysis indicating what could have been done more efficiently. Consideration is given to systems engineering and design definition, standards and tools, system architecture and design, operational considerations, and reuse and adaptation of existing resources.
    Keywords: COMPUTER PROGRAMMING AND SOFTWARE
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    NASA TECHNICAL REPORTS
  • 7
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    Selection effects and binary galaxy velocity differences (1990)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: Measurements of the velocity differences (delta v's) in pairs of galaxies from large statistical samples have often been used to estimate the average masses of binary galaxies. A basic prediction of these models is that the delta v distribution ought to decline monotonically. However, some peculiar aspects of the kinematics have been uncovered, with an anomalous preference for delta v approx. equal to 72 km s(sup-1) appearing to be present in the data. The authors examine a large sample of binary galaxies with accurate redshift measurements and confirm that the distribution of delta v's appears to be non-monotonic with peaks at 0 and approx. 72 km s (exp -1). The authors suggest that the non-zero peak results from the isolation criteria employed in defining samples of binaries and that it indicates there are two populations of binary orbits contributing to the observed delta v distribution.
    Keywords: ASTROPHYSICS
    Type: NASA, Marshall Space Flight Center, Paired and Interacting Galaxies: International Astronomical Union Colloquium No. 124; p 485-490
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    NASA TECHNICAL REPORTS
  • 8
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    A CAM-based LZ data compression IC (1993)
    In:  Other Sources
    Details
    Publication Date: 2013-08-29
    Description: A custom CMOS processor is introduced that implements the Data Compression Lempel-Ziv (DCLZ) standard, a variation of the LZ2 Algorithm. This component presently achieves a sustained compression and decompression rate of 10 megabytes/second by employing an on-chip content-addressable memory for string table storage.
    Keywords: COMPUTER PROGRAMMING AND SOFTWARE
    Type: New Mexico Univ., The Fifth NASA Symposium on VLSI design; 8 p
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    NASA TECHNICAL REPORTS
  • 9
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    Massive low surface brightness galaxies (1993)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: A multi-wavelength study of an extreme type of galaxy which will assist us in our attempts to understand the formation and evolution of galaxies was completed. In particular, a subset of low surface brightness (bar-mu(sub B) is approximately greater than 25 mag arcsec(sup -2)), giant galaxies (LSBG's) which contain large amounts of atomic gas (M(HI) is approximately greater than 10(exp 10) solar mass), have blue optical diameters similar to those of giant spiral galaxies, but which do not seem to have prodigious amounts of ongoing star formation were observed. Our sample was drawn from the first and second Palomar Sky Surveys. This population of galaxies has been largely ignored because of selection effects which make it difficult to detect optically. The question of how these massive systems differ from the higher surface brightness 'normal' spiral galaxies is addressed. Using B and R surface photometry, in conjunction with H-alpha, HI, CO-12, and far-infrared data, an attempt is made to determine if these galaxies had an early epoch of star formation that has since faded, have ongoing star formation with an unusual interplanetary magnetic field (IMF), or are perhaps galaxies which have never efficiently formed stars due to a lack of molecular clouds.
    Keywords: ASTROPHYSICS
    Type: NASA. Ames Research Center, The Evolution of Galaxies and Their Environment; p 84-85
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    NASA TECHNICAL REPORTS
  • 10
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    Optimal primary-backup protocols (1992)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: We give primary-backup protocols for various models of failure. These protocols are optimal with respect to degree of replication, failover time, and response time to client requests.
    Keywords: COMPUTER PROGRAMMING AND SOFTWARE
    Type: NASA-CR-190673 , NAS 1.26:190673 , TR-92-1299 , AD-A255494
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    NASA TECHNICAL REPORTS
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