ISSN:
1432-0827
Keywords:
22-oxa-1α, 25 Dihydroxyvitamin D3
;
1,25(OH)2D3
;
Bone histomorphometry
;
Bone Gla protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
,
Physics
Notes:
Summary Thein vivo effects of 22-oxa-1α, 25 dihydroxyvitamin D3 (OCT), on bone mineral metabolism were investigated in normal male Sprague-Dawley rats. The rats were administered either vehicle (control), low-dose OCT (25 ng/100 g body weight), or high-dose OCT (250 ng/100 g body wt). High-dose OCT increased serum ionized calcium (P〈0.05) and decreased serum parathyroid hormone (PTH) (P〈0.05) at all time points and increased serum bone Gla protein on days 7 and 28 (P〈0.05) compared with controls. Lowdose OCT decreased serum PTH at all the time points (P〈0.05) compared with controls. Tibial bone histomorphometry showed no significant differences between the two doses of OCT and controls. We found that OCT has minimal direct effects on bone metabolism in normal male rats in contrast to 1,25 dihydroxyvitamin D3. This property may be advantageous in the treatment with OCT of cell-proliferative diseases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00582166
Permalink
