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  • 2-Arylhydrazono-2-cyan-N-chloracetylacetamide  (1)
  • BAY w 8199  (1)
  • Polymer and Materials Science  (1)
  • General Chemistry
  • Industrial Chemistry
  • 1990-1994  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Synthese und Reaktionen von 2-Arylhydrazono-2-cyan-N,N-dialkyl-acetamidinen (1991)
    Springer
    Monatshefte für Chemie 122 (1991), S. 195-207 
    Details
    ISSN: 1434-4475
    Keywords: 5-Dialkylamino-2-aryl-1,2,3-triazoles ; 4-Amino-2,6-dioxo-tetrahydropyrid-3-yl-pyridiniumchloride ; 2-Arylhydrazono-2-cyan-N-chloracetylacetamide ; Arylhydrazono-2-cyan-N,N-dialkylacetamidines ; Arylhydrazonomalononitriles ; 4-Imino-5-arylazo-6-dialkylamino-1,4-dihydropyrimidines ; 13C-NMR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The title compounds3 were synthesized by reaction of arlyhydrazono-malononitriles1 with secondary amines and used for subsequent cyclization reactions. Thus,3 undergoes cyclooxidation by treatment with CuSO4/pyridine to form the 5-dialkylamino-2-aryl-1,2,3-triazolo-4-carbonitriles4. From4 a and hydrazine hydrate/DMF the 4-(1,3,4-triazolyl-5)-1,2,3-triazole5 c is obtainable. The chloroacetylation of3 is accompanied by hydrolysis of the amino group to yield the arylhydrazono-N-chloracetyl cyanoacetamides6. The quaternisation of6 with pyridins is followed by the Thorpe cyclization to form the 4-amino-5-arylazo-6-hydroxy-3-pyridinio-pyrid-2-on-chlorides8, useful as cationic dyes. The reaction of3 with trichloroacetonitriles yields the 5-arylazo-4-imino-2-trichlormethyl-1,4-dihydropyrimidines10 a–c which can be converted into the 5-arylazo-2-hydrazino-pyrimidine derivatives10 d–f. From10 d the 6-phenylazo-triazolo[4,3-a]pyrimidine derivative11 is obtainable. From3 and phenylisothiocyanate the 5-arylazo-4-imino-1,4-dihydropyrimidin-2-thiones12 arise. The structures were investigated by13C-NMR-spectroscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00809365
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of the active metabolite of the prodrug repirinast in healthy Caucasian volunteers after a single oral dose (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 307-312 
    Details
    ISSN: 1432-1041
    Keywords: Pharmacokinetics ; Caucasians ; Repirinast ; Antiallergic drug ; single dose ; oral administration ; metabolite ; BAY w 8199
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of BAY w 8199, the active metabolite of the prodrug repirinast (BAY u 2372), has been investigated after oral administration of 150, 300 and 450 mg repirinast to twelve healthy male Caucasians. Plasma BAY w 8199 concentrations were very variable between subjects. The mean peak level (geom. mean; 1s-range) was 0.14 (0.08–0.25), 0.19 (0.13–0.29) and 0.24 (0.14–0.42) mg/l after the 150, 300 and 450 mg doses, respectively. Peak levels were reached 0.5–2.5 h after drug intake. Terminal half-lives were calculated as 5.9 h (150 mg), 8.0 h (300 mg) and 9.8 h (450 mg). The dose proportionality of the plasma profiles of BAY w 8199 and of its excretion in urine was demonstrated by testing several parameters. About 7.4% of each dose (calculated as BAY w 8199) was excreted in urine over 36 h. The renal clearance of about 27 l/h suggests that BAY w 8199 is excreted by tubular secretion in addition to glomerular filtration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266353
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  • 3
    Electronic Resource
    Electronic Resource
    Hydrogels based on 2.2.3.3.4.4.4.-heptafluorobutyl methacrylate (1992)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 43 (1992), S. 335-342 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Hydrogele (vernetzte Polymere mit definiertem Wassergehalt) wurden aus hydrophilen Methacrylaten und Perfluorbutylmethacrylat durch radikalische Polymerisation und nachfolgende Quellung in gepufferter isotonischer Natriumchloridlösung hergestellt. Die erhaltenen Hydrogele wurden durch ihre lineare Quellung, den Wassergehalt, den Brechungsindex, den Gehalt an extrahierbaren Bestandteilen, ihre Transparenz für sichtbares Licht sowie durch ihre Sauerstoffpermeation charakterisiert. Derartige Hydrogele sind interessant als Materialien für Kontaktlinsen.
    Notes: Hydrogels (crosslinked polymers with a defined content of water) from hydrophilic methacrylates and perfluorobutyl methacrylate were prepared by radical polymerization, followed by swelling in buffered isotonic sodium chloride solution. The obtained hydrogel samples have been characterized by their linear expansion to hydration, weight-percent hydration, refractive index, extractables, percent transmission of visible light, and oxygen permeability. Such hydrogels are interesting as contact lens materials.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1992.010430608
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