ISSN:
1573-6830
Keywords:
CGP 42112
;
1-methyl-4-phenylpyridine
;
brain injury
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary 1. Intracerebral injection of the oxidative metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridine (MPP+), into the substantia nigra of adult rats resulted in a lesion at the injection site. 2. Using autoradiography, we localized specific [125]CGP 42112 binding that was not recognized by angiostensin II or angiotensin II AT1 or AT2 receptorselective ligands. 3. Our results suggest that [125I]CGP 42112 may be binding to activated microglia that appear at the lesion site.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02088592
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