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  • 1
    Electronic Resource
    Electronic Resource
    Determination of the acyl moieties of the antibiotic complex A40926 and their relation with the membrane lipids of the producer strainPresented in part at the Budapest 91 Informal Meeting on Mass Spectrometry, Budapest, June 3-5, 1991. (1992)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 6 (1992), S. 109-114 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Structures of the fatty acid characterizing the various components of A40926 were determined by gas chromatography/mass spectrometry on the methyl esters obtained by methanolysis of the complex. The results confirm the residues previously assigned to Factor A (n-Undecanoic acid) and B (10-methyl-undecanoic acid) and establish the residues of Factor A1(9-methyl-decanoic acid), B1 (n-dodecanoic acid), RS1 (8-methyl-nonanoic acid), RS2 (n-decanoic acid), and RS3 (n-tridecanoic acid). As the actinomadura species contain in their mycelia large quantities of C15-C17 fatty acid residues as membrane phospholipids, these mycelia were saponified and the fatty acids obtained were analyzed as above. There is a close correlation beterrn the fatty acid content of A40923 complex and that of longer homologues in the producer mycelia.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290060208
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  • 2
    Electronic Resource
    Electronic Resource
    Targeting polysaccharide-methotrexate conjugates to the rat brain (1992)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 3 (1992), S. 317-321 
    Details
    ISSN: 1042-7147
    Keywords: Cationic drug conjugates ; Blood/brain barrier ; Methotrexate brain concentrations ; Drug delivery ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Delivery of drugs to brain tumors is difficult due to the impermeability, and variable nature of the blood/tumor barrier. Of the various strategies designed to improve drug uptake-intracellularly and into the brain, cationic carriers seem to offer an advantage. In the current investigation cationic polysaccharide-methotrexate conjugates were examined in the rat. Conjugates were prepared from N,O-carboxymethyl chitosan (NOCC) and 3H-methotrexate (MTX) by two different synthetic schemes, resulting in NOCCMTX-1 and NOCCMTX-2. NOCCMTX-1 appeared to have a higher degree of cross-polymerization than NOCCMTX-2. Each conjugate and free MTX were administered intra-arterially in a retrograde manner in the external carotid artery at a MTX dose of 1 mg/kg as a constant rate infusion over 30 min. Animals were sacrificed at various times after administration, and blood and tissue samples collected, processed in a sample oxidizer, and then measured for radioactivity. Brain MTX concentrations were 18- and 12-fold greater at 15 min and 3 hr, respectively, following NOCCMTX-1 administration compared to free MTX treatment. However, NOCCMTX-1 resulted in animal death at about 12 hr after administration. NOCMTX-2 was found to be non-toxic, yet did not increase brain MTX concentrations compared to free drug administrations after correction for MTX in residual blood. Further investigations are planned to combine the positive drug targeting effect of NOCCMTX-1 with the safety of NOCCMTX-2.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1992.220030606
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  • 3
    Electronic Resource
    Electronic Resource
    Transformation of arginine into ornithine during the preparation of its tert-butyldimethylsilyl derivative for analysis by gas chromatography/mass spectrometry (1993)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 22 (1993), S. 698-702 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reaction of N-methyl-N-tert-butyldimethylsilyltrifluoroacetamide with arginine proceeds with cleavage of the guanidino group, producing a mixture of the tert-butyldimethylsilyl derivatives of ornithine and carbodiimide. These compounds are identified by analysing the reaction mixture using gas chromatography/mass spectrometry.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200221205
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  • 4
    Electronic Resource
    Electronic Resource
    Mass spectrometric techniques for structure and novelty determination of kirromycin-like antibiotics (1992)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 21 (1992), S. 51-59 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Direct liquid introduction negative ion mass spectra have been studied for some kirromycin class antibiotics. A scheme for the interpretation of the mass spectral fragmentation patterns is presented and shown to be useful for structure elucidation and novelty determination. Since these spectra are obtained by liquid chromatography/mass spectrometry, antibiotic isolates need not be highly purified. However, where pure preparations are available confirmation of molecular weight assignments may be obtained with fast atom bombardment ionization.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200210110
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  • 5
    Electronic Resource
    Electronic Resource
    Structure of toluene sulfonamide formal resins: Molecular models from mechanistic schemes and analytical results (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 49 (1993), S. 461-467 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Toluene Sulfonamide Formaldehyde Resins (TSFR), having elemental analysis close to (C8H9NSO2)n, are shown by GPC to exist as a mixture of a few (5 to 6) oligomers, having masses between 400 and 1900 g. A complete scheme of all the possible intermediates involved in their preparation is derived from the results of synthesis and from mechanistic steps; this allows one to propose the structure of oligomers having end groups OH and NH. IR, 1H NMR, and 13C NMR data on oligomers, compared to those of authentic samples specially designed and prepared, agree with the structures proposed. These results are helpful in designing modified or new resins to be used in nail lacquers. © 1993 John Wiley & Sons, Inc.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1993.070490310
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  • 6
    Electronic Resource
    Electronic Resource
    Electrochemical behavior of triazolobenzodiazepine derivativesDedicated to the memory of Professor G. J. Patriarche. (1994)
    Weinheim : Wiley-Blackwell
    Electroanalysis 6 (1994), S. 1040-1044 
    Details
    ISSN: 1040-0397
    Keywords: Triazolobenzodiazepine ; Voltammetry ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electrochemical behavior of two novel triazolobenzodiazepines (adinazolam and U43.465F) has been studied in the pH range 3 to 13.5. Both compounds are reduced on the dropping mercury electrode and yield one reduction wave attributed to the azomethine group. The two-electron transfer is polarographically reversible. However, the transfer is followed by a fast conversion of the elearolysis product by a chemical reaction with an irreversible global process. A weak adsorption of the reactant has been observed under certain conditions. Quantitative analysis has been performed, showing that adinazolam and U43,465F can be determined up to 1.1 × 10-6M using differential pulse polarography.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140061121
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  • 7
    Electronic Resource
    Electronic Resource
    A novel succinyl dipeptide stimulates directed cell migration by modulating protein kinase C activity (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 142 (1990), S. 401-409 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: In determining the mechanism of the chemokinetic action of the thiol protease inhibitor, E-64, in endothelial cell monolayers subjected to wounding, we synthesized succinyl-leucyl-agmatine (SLA), an analogue of E-64 that lacked the epoxy group and protease inhibitory effect. We observed that this analogue retained its chemokinetic effect on wounded endothelial cells. Its stimulatory action on en-dothelial cell polarization response to wounding was rapid and associated with directed cell migration. Furthermore, its effect on cellular polarization was blocked by protein kinase C (PKC) inhibitors and mimicked by pharmacologic agents that stimulated PKC activity. To determine if SLA's chemokinetic action was mediated by protein kinase C activation, we compared the effects of SLA and the tumor promoter phorbol myristate acetato (PMA) on the translocation of PKC activity in endothelial cells. We observed that both SLA and PMA induced the translocation of PKC activity from the cytosolic to the particulate fraction of the cells. We also observed that both SLA and PMA induced the phosphorylation of two proteins (Mr 23.4 and 36.5 kDa) in intact 32P-labeled cells. Thus, SLA stimulates the endothelial cell locomotor response to wounding by stimulating PKC activity.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041420225
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  • 8
    Electronic Resource
    Electronic Resource
    Role of Na+/H+ exchange in the granulocyte-macrophage colony-stimulating factor-dependent growth of a leukemic cell line (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 143 (1990), S. 133-139 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The growth of the human leukemia cell line AML-193 in a serum-free medium is strictly dependent on the presence of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), which is one of the major regulators of the myelomonocytic lineage. At present, little is known about the mechanisms by which this growth factor transduces the signal intracellularly. The results of this study demonstrate that GM-CSF needs the operation of a Na+/H+ exchanger, which is located in the plasma membrane of almost every vertebrate cell. In fact, the GM-CSF-dependent proliferation of AML-193 cells is strongly reduced in the presence of the amiloride analog EIPA, a specific inhibitor of the Na+/H+ exchanger. When acidified, AML-193 cells are able to recover the original pH, in a Na+-dependent and EIPA-inhibitable way; this demonstrates for the first time the presence of the Na+/H+ exchanger in these cells. Finally, GM-CSF, at doses superimposable to those needed for triggering proliferation, induces in AML-193 cells a sustained alkalinization, which is dependent on a operating Na+/H+ exchange, as it is inhibited by EIPA. These results suggest that GM-CSF, like other growth factors in other cell systems, exerts its mitogenic activity in AML-193 cells by inducing a Na+/H+ exchanger-mediated rise in pHi.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041430118
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  • 9
    Electronic Resource
    Electronic Resource
    Contribution of mass spectrometric techniques to the structure elucidation of antibiotic GE2270A, a novel inhibitor of bacterial protein synthesis (1992)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 27 (1992), S. 219-225 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: GE2270A is a novel antibiotic active against Gram-positive bacteria and anaerobes. Its structure originates from a peptidic backbone, the amino acids of which have been modified to produce a macrocycle and a side-chain. It contains a heterocyclic chrornophonc system, a number of thiazoleamino acids and three unmodified natural amino acids. The structure [relative molecular mass (RMM) 1289] was determined using various spectroscopic techniques, of which fast atom bombardment mess spectrometry, gas chromatography/mass spectrometry, desorption chemical ionization mass spectrometry and fast atom bombardment tandem mass spectrometry played an important role. The mass spectrometric approach was applied to the intact molecule and to the various hydrolysis products, including the chromophoric part (RMM 634).
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210270312
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  • 10
    Electronic Resource
    Electronic Resource
    Mechanical properties-structure relationship in blends of polyamide 6 with γ-irradiated LDPE (1993)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 33 (1993), S. 1336-1340 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Blends of γ-irradiated and unirradiated low density polyethylene with polyamide 6 were made in order to study possible modifications induced by this irradiation. Blends with γ-irradiated polyethylene show structure and properties significantly different with respect to blends made with the unirradiated polyethylene. In this paper data on mechanical properties (tensile and impact) of these blends are presented. Results are related to the different morphologies in the blends.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760332006
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