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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 85 (1990), S. 319-323 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The PstI polymorphism detected by probe KM19 is a highly informative marker in linkage disequilibrium with the cystic fibrosis locus and has been used extensively for prenatal diagnosis. The currently available primers used for polymerase chain reaction- (PCR-) based analysis of this locus have been shown to produce spurious amplification products. In this report, we describe the sequence of the KM19 locus and the major contaminating PCR product. We have used this information to design a more specific amplification procedure for analysis of the KM19 locus.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-739X
    Keywords: Antibiotics ; Automatic data processing ; Costs and cost analysis ; Data collection ; Drug utilization ; Formularies, hospital
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract To identify the most suitable method to continuously monitor antibiotic prescriptions in a United Kingdom hospital, a study was performed in three phases over four years between 1985 to 1989 in a Liverpool teaching hospital. The aim of the study was to perfect a method to collect and analyse hospital-wide antibiotic prescribing data. The emphasis was laid on identifying problems and practicalities and also to minimize manpower and resource requirements. The data were used to illustrate the effect of the hospital's antibiotic policy on prescribing trends. The policy recommendation that co-trimoxazole be substituted by trimelhoprim was only partially adhered to because Augmentin® was the other replacement antibiotic in a significant number of cases. Therefore, it is important to monitor the effects of target drug programmes on all antibiotics since certain sequelae may be unexpected. A total of 1,804, 2,526 and 3,226 antibiotic prescriptions were collected and analysed during phases I, II and III respectively. 72–73% of the prescriptions were for the treatment of infection which equated to 81–89% of the total antibiotic cost. Therefore, cost control campaigns need to concentrate on infection treatment as opposed to prophylaxis. Specifically, respiratory tract, septicaemia and pyrexias of unknown origin account for the bulk of antibiotic expenditure. The method for phases I and II was multidisciplinary and very time-consuming. Phase III was very fast in operation, with data collection and analysis being performed on a single computer dedicated for the task. The minimum staff required to monitor all antibiotic prescriptions is one full-time pharmacist and clerk. Continuous intensive antibiotic monitoring in United Kingdom hospitals will not be feasible until antibiotic prescription forms are introduced on all wards.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 32 (1992), S. 54-61 
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Local-velocity feedback (LVF) and linear-quadratic Gaussain (LQG) control schemes are implemented on passively tuned reaction mass actuators to control the vibrations of a flexible structure. The structure is lightly damped and possesses closely coupled low-frequency resonant modes. Both LVF and LQG controllers successfully eliminate the structure's vibrations. However, if the passive tuning parameters of the actuators are slightly mistuned, implementing LVF control actually results in an unstable system. On the other hand, LQG control proves to be insensitive to large changes in the passive tuning parameters of the actuators. In fact, the system with LQG control is never unstable, no matter what the actuator's passive tuning parameters are.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 1992-03-01
    Print ISSN: 0014-4851
    Electronic ISSN: 1741-2765
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Springer
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