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  • 1
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 39 (1993), S. 1124-1134 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Two-phase flow in porous media is described based on the extended form of Darcy's law, which ignores momentum transfer at fluid-fluid interfaces. Two forms of corrections to this simple description have been proposed in the literature: one on the relative permeability dependence on viscosity ratio; the other on the velocities assumed to be proportional to both phase pressure gradients and so introducing an additional saturation-dependent cross coefficient.In this article, to identify the correct form of transport equations, a simple cubic network model of 30 × 30 × 30 bonds is used. The cross section of the bonds is that of a four-cusp duct. The fluid interface in each duct is located by capillary equilibrium. The duct hydraulic conductances are then obtained as a function of viscosity ratio and phase volume fraction using a finite element calculation. These individual duct results are used in the network calculations for which a percolation algorithm is applied to simulate nonwetting phase displacing wetting phase, a process also known as initial drainage. Flow calculations show that both the nonwetting-phase relative permeability and the cross coefficient are strong functions of saturation and viscosity ratio. Also, the off-diagonal terms may contribute to a nonnegligible fraction of the flow. The proposed generalization of the Darcy equations is applicable to all problems involving multiphase flow in porous media. The current practices for relative permeability measurements and reservoir simulation may have to be reexamined in the context of the proposed transport equations.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 142 (1990), S. 480-487 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Treatment of M5076 tumor cells with the phorbol esters 12-O-tetradecanoyl-phorbol 13-acetate (TPA) and phorbol 12, 13 dibutyrate (PdBu) inhibited cellular proliferation, whereas 1,2-dioctanoyl-glycerol (DiC8) and 1-oleoyl2-acetyl-glycerol (OAG) did not affect cell growth. Inhibition of cellular proliferation in this cell line appears to be a consequence of protein kinase C (PKC) down-regulation since phorbol esters, but not a single application of diacylglycerols (DGs) down-regulated cellular PKC levels. By repeated application of DGs, PKC down-regulation was achieved and correlated with inhibition of proliferation. Phorbol ester-induced PKC down-regulation was reversible, upon removal of the phorbol ester, and the reappearance of PKC was associated with resumption of proliferation. The mitogenic responsiveness of these cells to added serum depended upon cellular PKC levels. Phorbol esters also caused the phosphorylation of two proteins which were not phosphorylated in response to DG treatment. Inhibition of growth of M5076 cells appears to be associated with phosphorylation of two novel proteins and/or PKC down-regulation.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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