ISSN:
1573-904X
Keywords:
microbial and mammalian metabolism
;
antimalarial
;
arteether
;
two-dimensional nuclear magnetic resonance (2D-NMR) techniques
;
thermospray liquid chromatography/mass spectros-copy (LC/MS)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Microbial metabolism studies of the antimalarial drug arteether (1) have shown that arteether is metabolized to six new metabolites in addition to those previously reported (3). Large-scale fermentations with Cunninghamella elegans (ATCC 9245) and Streptomyces lavendulae (L-105) have resulted in the characterization of these metabolites primarily by two-dimensional nuclear magnetic resonance (2D-NMR) methods as 9β-hydroxyarteether (2), a ring rearrangement metabolite (3), 3α-hydroxy-11-epi-deoxydihydroartemisinin (4), 9α-hydroxyarteether (5), 2α-hydroxyarteether (6), and 14-hydroxyarteether (7). Thermospray mass spectroscopy/high-performance liquid chromatographic analyses have shown that four of these metabolites (2, 5, 6, 7) are also present in rat liver microsome preparations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015993722846
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