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Proteasomes (prosomes) inhibit the translation of Tobacco mosaic virus RNA by preventing the formation of initiation complexes (1994)

Homma, Susanne ; Horsch, Andrea ; Pouch, Marie-Noëlle ; [et al.]

Springer

Molecular biology reports 20 (1994), S. 57-61

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ISSN: 1573-4978

Keywords: proteasomes ; prosomes ; Tobacco mosaic virus RNA ; translation inhibition ; initiation complexes

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Proteasomes (prosomes) are large multiprotein complexes. They are involved in protein degradation of ubiquitin-conjugated proteins and in the generation of MHC class I peptides. We gave further evidence that they interfere within vitro protein synthesis. Proteasomes inhibit the translation of Tobacco mosaic virus RNA. Analysis of cell-free systems by sucrose gradient centrifugation revealted that they prevent the formation of 80S initiation complexes but not the early phase of initiation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00996354

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