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  • 1
    Electronic Resource
    Electronic Resource
    A nonlinear three-compartiment model for the administration of 2′,3′-dideoxycytidine by using red blood cells as bioreactors (1990)
    Springer
    Bulletin of mathematical biology 52 (1990), S. 785-796 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract A non-linear three-compartment model is proposed to describe a new strategy for the administration of 2′,3′-dideoxycytidine (ddCyd) in the treatment of HIV infections. The drug is injected after having been encapsulated in a non-diffusible form (ddCMP) into erythrocytes. Nummerical solutions show that by this treatment the highest ddCyd blood concentration is strongly reduced and in turn its toxicity, while long-lasting therapeutic effect is assured. The model is compared with experimental data in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02460809
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  • 2
    Electronic Resource
    Electronic Resource
    Project analysis using a linear approach (P.A.U.L.A.) (1993)
    Springer
    Decisions in economics and finance 16 (1993), S. 73-86 
    Details
    ISSN: 1129-6569
    Keywords: project analysis ; linear programming ; internal financial law (IFL) ; financial leverage ; discounted cash-flows (DCF) decomposition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Description / Table of Contents: Riassunto Si definisce un modello generale (PAULA) per la valutazione, selezione e gestione ottimale di progetti certi alternativi. Sfruttando i risvolti formali e finanziari dei problemi lineari associati (diretto e duale), si formulano poi due proposte per definire una legge finanziaria interna (IFL) ottimale, utili sia per abbattere la molteplicità intrinseca delleIFL, sia per evitare risultati economicamente arbitrari nel loro uso.
    Notes: Abstract We define a general model (called PAULA) for the valuation, optimal management and selection among mutually exclusive safe projects. By exploiting the formal and financial features of the associated linear problems (primal and dual), we put forward two proposals to define an optimal internal financial law (IFL). They may be used to reduce the multiplicity of the IFLs and to avoid economically arbitrary outcomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02086763
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular analysis of G6PD variants in northern Italy: a study on the population from the Ferrara district (1993)
    Springer
    Human genetics 〈Berlin〉 92 (1993), S. 139-142 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In the Ferrara district, an area south of the Po delta, four different variants of glucose-6-phosphate dehydrogenase (G6PD;E.C.1.1.49) have been described as a result of biochemical characterization of the enzyme protein: one was G6PD Mediterranean (G6PD Med) and three were local variants named Ferrara I, II, and III. The Ferrara I variant was recently analysed at the DNA level and shown to correspond to G6PD A376G/202A, while the mutations causing the variants II and III, still remain unknown. We analysed the G6PD coding region of 18 apparently unrelated G6PD deficient subjects, whose families have lived in the Ferrara district for at least three generations: 12 subjects had G6PD Med563T/1311T, 3, G6PD Santamaria376G/542T and 2, G6PD A-376G/202A. In one subject we found a new mutation, a G→A transition at nucleotide 242 causing an Arg→His amino acid replacement at position 81. We named this new variant G6PD Lagosanto242 A. Phenotypically the enzyme has nearly normal kinetic properties and appears different from the variants Ferrara II and III.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219681
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  • 4
    Electronic Resource
    Electronic Resource
    Flecainide: evidence of non-linear kinetics (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 57-59 
    Details
    ISSN: 1432-1041
    Keywords: Flecainide ; pharmacokinetics ; ventricular arrhythmias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of flecainide has been studied in 12 patients with ventricular arrhythmias, both after single administration and during chronic treatment. Both the half-life and the AUC were significantly increased during chronic treatment. This suggests that the kinetics of flecainide might be non-linear also in patients with normal kidney and liver function. The increase in plasma flecainide levels during chronic treatment could not be predicted, so close monitoring of its plasma levels is advisable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280107
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  • 5
    Electronic Resource
    Electronic Resource
    In situ ATR/FTIR studies of protein adsorption on polymeric materials: effectiveness of surface heparinization (1994)
    Springer
    Journal of materials science 5 (1994), S. 839-843 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The adsorption of two proteins from human plasma (human serum albumin (HSA) and human fibrinogen (HFG) onto six different polymeric surfaces (two of which are heparinized), has been studied byin situ ATR/FTIR spectroscopy. The different surface characteristics are reflected by different interfacial behaviours of the two proteins, but while both proteins unfold upon adsorption on all the different non-heparinized materials, they maintain the native conformation once adsorbed on the heparinized surfaces. These findings emphasize the effectiveness of surface heparinization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01172021
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  • 6
    Electronic Resource
    Electronic Resource
    Sulfated hyaluronic acid as heparin-like material: physicochemical and biological characterization (1994)
    Springer
    Journal of materials science 5 (1994), S. 830-833 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Hyaluronic acid was partially sulfated and a polymer containing a precise number of sulfate groups for each repeating unit was prepared. The properties of this macromolecule in aqueous solution were studied at different pH levels by using potentiometric, viscosimetric techniques and were compared with that of the native hyaluronic acid, partially esterified hyaluronic acid and heparin. The influence of sulfate groups on the macromolecule is evident in the protonation constant and in the conformation of the polymer. This material exhibits an antithrombotic effect as evidenced by the lengthening of both the thrombin time and the whole blood clotting time. Moreover, the absence of hemolysis and the growth and shape of endothelial cells put in contact with the sulfated hyaluronic acid indicate that this polymer is a promising heparin-like compound.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213143
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  • 7
    Electronic Resource
    Electronic Resource
    Preparation and characterization of monoclonal antibodies to human hexokinase type I (1990)
    Springer
    Molecular and cellular biochemistry 97 (1990), S. 145-151 
    Details
    ISSN: 1573-4919
    Keywords: hexokinase ; monoclonal antibodies ; comparative studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract 1. Three different immunization protocols and several screening procedures were used to prepare seven mouse monoclonal antibodies to human placenta hexokinase type I. None of these monoclonals were able to recognize the native enzyme but all detected hexokinase when adsorbed onto polystyrene plates or on immunoblots after SDS/polyacrylamide-gel electrophoresis. 2. All seven monoclonals recognize the two different subtypes of human hexokinase I equally well. Limited tryptic digestion of hexokinase followed by Western blotting and immunodetection show that these monoclonals recognize epitopes that lie in different tryptic peptides. 3. Comparative ELISA studies showed that human hexokinase types I and II have great immunological similarities while hexokinase I from different mammalian species and yeast hexokinase are recognized with different affinities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221056
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  • 8
    Electronic Resource
    Electronic Resource
    Cloning and expression of a new human polypeptide which regulates protein phosphorylation in Escherichia coli (1991)
    Springer
    Molecular and cellular biochemistry 107 (1991), S. 87-94 
    Details
    ISSN: 1573-4919
    Keywords: protein phosphorylation ; human polypeptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary A 1,820bp full-length clone encoding for a new human protein was isolated from a λgt11 placental cDNA library using anti-human hexokinase antibodies. The cDNA complete sequence includes a 12 by 5′ noncoding region, a single open reading frame encoding a protein of 55 KDa (HP-10) and a 177 by non-coding with two putative polyadenylation signals upstream of 3′poly(A)tail. The deduced amino acid sequence reveals a sequence of 492 amino acids that contains a stretch of 7 glutamic acid from position 169 and one potential glycosylation site at position 274. Although antibodies against hexokinase recognize the fusion protein and antibodies against the fusion protein recognize hexokinase, HP-10 is not human hexokinase, by a number of criteria including the alignment of determined amino acid sequences. In searching for a possible functional role of HP-10 its cDNA was inserted into a procaryotic vector which allows the expression of the non-fused protein. Bacteria expressing the HP-10 encoded protein were isolated and found to have a dramatic increase in endogenous phosphorylated proteins. Since HP-10 does not have a protein kinase activity per se it should be considered a new regulatory phosphorylation protein which is active in E. coli
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225511
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  • 9
    Electronic Resource
    Electronic Resource
    Similarities and differences between human and rat hexokinases type I (1990)
    Springer
    Molecular and cellular biochemistry 94 (1990), S. 105-111 
    Details
    ISSN: 1573-4919
    Keywords: hexokinases I ; peptide mapping ; immunological properties ; human ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The intracellular distribution and several properties of hexokinases type I purified to homogeneity from human placenta and rat brain were compared. The specific activity of the human enzyme was 190 ± 5 U/mg protein; 140 ± 5 U/mg protein that of the rat hexokinase. Comparative peptide mapping after limited tryptic digestion indicates a similar domain structure, however analogous experiments performed in the presence of substrates or effectors of the enzyme provide evidence of significant differences among hexokinases. Similarly, immunological studies with polyclonal and monoclonal antibodies while confirming some common epitopes also disclose important differences that cannot be expected on the basis of amino acid composition and of an in vivo identical function. These results are consistent with suggestions by several investigators that amino acid substitutions in mammalian hexokinases have occurred at a relatively fast rate during hexokinase type I evolution
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214117
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  • 10
    Electronic Resource
    Electronic Resource
    Intracellular distribution of hexokinase in rabbit brain (1993)
    Springer
    Molecular and cellular biochemistry 122 (1993), S. 123-132 
    Details
    ISSN: 1573-4919
    Keywords: hexokinase ; intracellular distribution ; rabbit brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Hexokinase in mammalian brain is particulate and usually considered to be bound to the outer mitochondrial membrane. Investigation of rabbit brain mitochondria prepared either by differential centrifugation and discontinuous density gradient centrifugation has provided evidence that this particulate fraction also contains endoplasmic vesicles and synaptosomes. Solubilization of the bound hexokinase by different combinations of detergents and metabolites has proved the existence of different hexokinase binding sites. Electron microscopic examination of hexokinase location by immuno-gold labelling techniques confirmed, that hexokinase is indeed predominantly bound to mitochondria but that a significant proportion is also bound to non-mitochondrial membranes. Attempts to quantify this distribution were unsuccessful since different figures were obtained using anti-hexokinase IgG affinity purified on immobilized native or denatured hexokinase. Binding studies of the purified rabbit brain mitochondrial hexokinase to rabbit liver mitochondria and microsomes confirmed that in addition to a binding site on mitochondria there is another binding site on microsomes. The N-terminal sequence of hexokinase has been shown to be important for mitochondria binding and also for microsome binding. These results suggest that the intracellular localization of hexokinase in rabbit brain is not exclusively mitochondrial and that the metabolic role of this enzyme should be reconsidered by including a binding site on the endoplasmic reticulum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01076096
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