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  • Antibiotic biosynthesis  (2)
  • Springer  (2)
  • American Geophysical Union (AGU)
  • 1990-1994  (2)
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Keywords
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  • Springer  (2)
  • American Geophysical Union (AGU)
Years
  • 1990-1994  (2)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of penicillin biosynthetic enzymes by halogen derivatives of phenylacetic acid (1994)
    Springer
    Journal of industrial microbiology and biotechnology 13 (1994), S. 144-146 
    Details
    ISSN: 1476-5535
    Keywords: Penicillin ; Halogenated phenylacetic acid ; Antibiotic biosynthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The effect of phenylacetic acid (PAA) and several analogs on the activity of isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransferase (AT) fromPenicillium chrysogenum Wis 54-1255 has been tested. Whereas the substitution on the ring of a hydrogen atom by hydroxy-, methyl- or methoxy- groups did not cause any effect, the presence of halogens (Cl or Br) at positions 3 and/or 4 of PAA strongly inhibited these two enzymes. The replacement of hydrogen atoms by fluorine in certain positions also caused inhibition, but to a lesser extent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01583998
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  • 2
    Electronic Resource
    Electronic Resource
    Organisation and functions of the actV A region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor (1991)
    Springer
    Molecular genetics and genomics 230 (1991), S. 401-412 
    Details
    ISSN: 1617-4623
    Keywords: Antibiotic biosynthesis ; Antibiotic resistance ; Hydroxylases ; Streptomyces
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Sequence analysis of the actVA region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor revealed a succession of six open reading frames (ORFs), all running in the same direction and extending over 5.32 kb. The protein product of actVA-ORF1 strongly resembles that of another gene, elsewhere in the act cluster (actII-ORF2), which codes for a trans-membrane protein previously implicated in actinorhodin export from the mycelium. This suggests that the two gene products may co-operate in actinorhodin export, perhaps being sufficient for self-protection of the organism against suicide. At least four of the other five ORFs are implicated in the control of the C-6 and C-8 ring-hydroxylation reactions, lacking in actVA mutants, that occur at middle to late stages in the actinorhodin biosynthetic pathway. This conclusion was reached by genetic mapping of actVA mutants to actVA-ORF3 and-ORF5 (and perhaps -ORF4), and by the finding of strong resemblances between the protein products of actVA-ORF2 and -ORF6 and the products of genes of the oxytetracycline or tetracenomycin gene clusters that have been implicated in ring-hydroxylation reactions in the biosynthesis of these other aromatic polyketide antibiotics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280297
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    Paper (German National Licenses)
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