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  • European corn borer  (3)
  • healthy volunteers  (3)
  • Springer  (6)
  • American Geophysical Union
  • American Geophysical Union (AGU)
  • American Physical Society (APS)
  • Elsevier
  • 1990-1994  (6)
Collection
Publisher
  • Springer  (6)
  • American Geophysical Union
  • American Geophysical Union (AGU)
  • American Physical Society (APS)
  • Elsevier
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 47 (1991), S. 980-984 
    ISSN: 1420-9071
    Keywords: European corn borer ; Ostrinia nubilalis ; sex pheromone polymorphism ; interracial hybrids ; F1 male-response profiles ; flight tunnel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Unlike the narrow response windows exhibited by the parent races, hybrid male European corn borers resulting from crosses of the E and Z races respond to a wide range of sex pheromone blends. The F1 response profile consists of some individuals that respond to both the Z pheromone and the 65∶35 E/Z blend produced by F1 females. Some F1 males fail to respond to any blend and some do not respond as broadly as others. The hybrid male populations, however, are not tuned optimally to the pheromone blend produced by F1 females and there is no coupling of F1 blend production and response.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 46 (1994), S. 361-365 
    ISSN: 1432-1041
    Keywords: Flosequinan ; Xamoterol ; pharmacodynamic interactions ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The possible cardiovascular pharmacodynamic interactions at rest and during exercise of combining oral flosequinan (100 mg) with xamoterol (200 mg) was investigated in a four-way randomised double-blind placebo-controlled crossover trial in eight healthy male volunteers. Xamoterol was better tolerated than flosequinan. The most common adverse events were mild to moderate headache and facial flushing. One volunteer developed headache and vomiting following flosequinan treatment and was replaced. Compared to placebo, at supine rest, flosequinan significantly increased heart rate (HR) by 5 beats·minv1, but had no effect on cardiac output (CO), stroke volume (SV) and mean blood pressure (MBP). Xamoterol significantly increased CO by 1.5 l·min-1, HR (5 beats·min-1) and MBP (6 mmHg) but not SV. The combined treatment (flosequinan + xamoterol) significantly increased CO (1.71·min-1) and HR (10 beats·min-1), but had no effect on SV and MBP. During exercise, flosequinan had no significant effect on any variable compared to placebo. Both xamoterol and combined treatment reduced the increase in CO (-4.61·min-1 after xamoterol and -3.41·min-1 after combined treatment vs. 0.1 l·min-1 after placebo), but had no effect on other variables. The effect of the combined treatment on each haemodynamic variable were no more than the anticipated additive effects of the two drugs. Thus, no cardiovascular pharmacodynamic interaction was found between flosequinan and xamoterol in healthy volunteers.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1041
    Keywords: Savoxepine ; Neuroleptic drug ; dopamine D2 receptor antagonist ; positron emission tomography ; striatal receptor binding ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The extent and duration of striatal dopamine-D2 receptor occupancy by savoxepine in humans has been studied using positron emission tomography with [11C]-raclopride, in order to investigate why the anticipated favourable ratio between its extrapyramidal and antipsychotic effects was not achieved in practice. After 0.25 mg savoxepine, striatal D2 receptor occupancy peaked at 50–60% after 24–36 h and disappeared within 6 days. After doses of 0.1 mg to 0.5 mg, D2 receptor occupancy in the putamen and caudate nucleus increased from 20 to 70% 3–7 h after administration and amounted to 40 to 75% at the peak time (20–29 h). This suggests that cumulative D2 receptor blockade would occur if equal or increasing doses of savoxepine were given repeatedly. Extrapyramidal adverse-effects would be likely to occur under such circumstances. An adequate test of the theory that preference for hippocampal dopamine D2 receptors with afford a good therapeutic ratio requires an alternative dosing regimen.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 38 (1990), S. 165-169 
    ISSN: 1432-1041
    Keywords: nicotine ; cimetidine ; ranitidine ; pharmacokinetics ; H2-receptor antagonists ; hepatic oxidation ; renal secretion ; tobacco smoking ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a randomized, double-blind, cross-over experiment, 6 healthy consenting male subjects were administered cimetidine 600 mg or ranitidine 300 mg or placebo p.o. q12h×2 days. Nicotine bitartrate was administered i.v. on day 2 (1 ug/kg/min)×30 min. After cimetidine mean nicotine total and metabolic clearances were decreased by 30% and 27% while after ranitidine the clearances were decreased by 10% and 7% respectively. Since smokers regulate their smoke intake based in large part on their nicotine blood levels these results suggest that the diminished nicotine total clearance in the presence of cimetidine could be important in assisting smoking reduction or cessation.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-5060
    Keywords: Zea mays ; maize ; Ostrinia nubilalis ; European corn borer ; resistance ; taxonomy ; germplasm ; indigenous land races
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The resistance to the European corn borer, Ostrinia nubilalis (Hubner), of thirty-seven indigenous landraces of Mexican maize was examined. The relationship of resistance and existing taxonomy of maize according to Wellhausen et al., (1952), was subjected to numerical analyses. Variables examined were: seedling DIM-BOA content, the extent of leaf feeding damage by early instar larvae both in the field and in the laboratory, the extent of plant breakage and stalk tunneling by late instar larvae, plant height, and the extent of fungal damage by Gibberella zeae and Ustilago maydis. Significant differences in resistance among the major taxonomic groupings were reflected in the existing taxonomy of maize (Wellhausen et al., 1952). The most resistant landrace grouping was Wellhausen et al.'s Prehistoric Mestizos. Eighty-five percent of a series of modern inbred lines, pools, and Argentine landraces were found to have affinities with one of the more susceptible groupings, the Ancient Indigenous Races, based upon analysis of the resistance data.
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  • 6
    ISSN: 1573-1561
    Keywords: Ostrinia nubilalis ; European corn borer ; Pyralideae ; Lepidoptera ; cytochrome P-450 ; cytochrome b5 ; cytochromec reductase ; glutathioneS-transferase ; α-terthienyl ; phototoxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The biochemical basis for the tolerance of the European corn borer,Ostrinia nubilalis, to the phototoxinα-terthienyl was investigated by measuring the midgut polysubstrate monooxygenases and glutathioneS-transferase activities.α-Terthienyl administered in the diet to the corn borers increased the level of cytochromeb 5, NADH-cytochromec reductase,O-demethylase, and glutathioneS-transferase activities. The induced detoxification enzyme activities should enable the corn borer to metabolizeα-terthienyl more efficiently and therefore render the corn borer highly tolerant toα-terthienyl.
    Type of Medium: Electronic Resource
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