Publication Date:
1991-10-04
Description:
Insects and other invertebrates use glutamate as a neurotransmitter in the central nervous system and at the neuromuscular junction. A complementary DNA from Drosophila melanogaster, designated DGluR-II, has been isolated that encodes a distant homolog of the cloned mammalian ionotropic glutamate receptor family and is expressed in somatic muscle tissue of Drosophila embryos. Electrophysiological recordings made in Xenopus oocytes that express DGluR-II revealed depolarizing responses to L-glutamate and L-aspartate but low sensitivity to quisqualate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and kainate. The DGluR-II protein may represent a distinct glutamate receptor subtype, which shares its structural design with other members of the ionotropic glutamate receptor family.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schuster, C M -- Ultsch, A -- Schloss, P -- Cox, J A -- Schmitt, B -- Betz, H -- New York, N.Y. -- Science. 1991 Oct 4;254(5028):112-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zentrum fur Molekulare Biologie, Universitat Heidelberg, Federal Republic of Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1681587" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Cloning, Molecular
;
DNA/genetics
;
Drosophila melanogaster/*genetics/physiology
;
Gene Expression
;
Glutamates/pharmacology
;
Glutamic Acid
;
Molecular Sequence Data
;
Muscles/*physiology
;
Oligonucleotides/chemistry
;
Receptors, Glutamate
;
Receptors, Neurotransmitter/*genetics/physiology
;
Sequence Alignment
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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