Publication Date:
1992-03-13
Description:
Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are multifunctional cytokines with many similar activities. LIF is structurally and functionally related to another cytokine, Oncostatin M (OSM), that binds to the high-affinity LIF receptor but not to the low-affinity LIF receptor. A complementary DNA was isolated that encodes the high-affinity converting subunit of the LIF receptor. The converter conferred high-affinity binding of both LIF and OSM when expressed with the low-affinity LIF receptor and is identical to the signal transducing subunit of the IL-6 receptor, gp130. The gp130 subunit alone confers low-affinity binding of OSM when expressed in COS-7 cells. This receptor system resembles the high-affinity receptors for granulocyte-macrophage colony-stimulating factor, IL-3, and IL-5, which share a common subunit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gearing, D P -- Comeau, M R -- Friend, D J -- Gimpel, S D -- Thut, C J -- McGourty, J -- Brasher, K K -- King, J A -- Gillis, S -- Mosley, B -- New York, N.Y. -- Science. 1992 Mar 13;255(5050):1434-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunex Research and Development Corporation, Seattle, WA 98101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1542794" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Antigens, CD
;
Binding, Competitive
;
Cell Line, Transformed
;
Cytokine Receptor gp130
;
Growth Inhibitors/*metabolism
;
Interleukin-6/*metabolism
;
Leukemia Inhibitory Factor
;
Lymphokines/*metabolism
;
Membrane Glycoproteins/*metabolism
;
Oncostatin M
;
Peptides/*metabolism
;
Radioligand Assay
;
*Receptors, Cytokine
;
Receptors, Immunologic/*metabolism
;
Receptors, OSM-LIF
;
Recombinant Proteins/metabolism
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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