ISSN:
0899-0042
Keywords:
trans-nor-pentazocine
;
Sigma
;
PCP
;
NMR analysis
;
GC analysis
;
chiral derivatizing reagents
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
An efficient resolution of (±)-trans-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan has been developed employing ( - )-(R)- and (+)-(S)-O-acetylmandelic acids. Measurement of optical rotations on the resolved bases, NMR analyses of diastereomeric urea derivatives, as well as gas chromatographic analyses of diastereomeric amide derivatives indicate a net improvement over previous resolution methodology and an enantiomeric excess ≥ 99%. © 1992 Wiley-Liss, Inc.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.530040707
Permalink