ISSN:
0749-1581
Keywords:
1H NMR
;
19F Corticosteroids
;
1H-19F long-range coupling
;
Heteronuclear COSY
;
1H-19F 2D correlation
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The analysis of the 1H and 19F NMR spectra of the corticosteroid fluocinonide and five related steroids is reported. The 500 MHz 1H NMR spectra revealed several previously undetected long-range 1H-19F coupling constants. These couplings were assigned by the application of the heteronuclear equivalent of the COSY pulse sequence. The fluorine substituent effects and long-range heteronuclear couplings were examined in relation to structures derived from molecular mechanics (MMX) calculations.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260290417
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