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  • Springer  (128)
  • Cell Press  (13)
  • Public Library of Science (PLoS)
  • 1990-1994  (129)
  • 1965-1969  (12)
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  • 11
    Electronic Resource
    Electronic Resource
    Conservation of the central MHC genome: PFGE mapping and RFLP analysis of complement, HSP70, and TNF genes in the goat (1990)
    Springer
    Immunogenetics 31 (1990), S. 253-264 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A degree of conservation of the genes located between class II and class I [central major histocompatibility complex (MHC) genes] is apparent among mammalian species including primates and the mouse. Few others have been analyzed. The caprine MHC is of particular interest, since it has recently been observed that susceptibility to a lentivirus-induced polyarthritis (caprine arthritis) segregates with serologically defined MHC class I antigens. This arthritis resembles, in a number of respects, rheumatoid arthritis in man. Human cDNA probes were used to examine the caprine central MHC and class I and II genes by restriction fragment length polymorphism (RFLP) and by pulsed field gel electrophoresis (PFGE) in order to define the polymorphism and linkage of central MHC genes to class I and class II genes. An outbred population of dairy goats (Saanen, British Alpine, Anglo Nubian, and Toggenberg) was examined for class I and class II RFLPs. Both regions were found to be highly polymorphic. The number of fragments hybridizing to an HLA-B7 probe after Eco RI, Bam HI, Bgl II, or Hind III digestion suggests there may be 10–13 class I genes. The degree of polymorphism was comparable to that reported in the mouse. Limited polymorphism was found in the central MHC genes. The caprine C4 and CYP21 genes were duplicated and demonstrated RFLP with Bam HI, Hind III, Eco RV, and Taq I. An infrequent Taq I C2 polymorphism was found. PFGE revealed substantial conservation of both the order and linkage of the central MHC genes when compared with mous and man. C4, C2, CYP21, HSP70, and tumor necrosis factor (TNF) genes are all located within 800 kilobase (kb) of the class I loci. Distant from the class I region, the C4, C2, and CYP21 genes are linked on a short genomic segment (180 kb Not I and 190 kb Pvu I fragments). HSP70 cohybridizes with the complement genes on a 380 kb Mlu I fragment. Linkage of HSP70, TNF, and class I genes was found on a single Not I fragment (610 kb). TNF and class I cohybridize on Pvu I (730 kb) and Not I (610 kb) fragments. Conservation of a similar central MHC genomic structure across species argues for functional interaction between the central MHC genes. We postulate selection for these central MHC genes through their role as non antigen-specific regulators of immune response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00204897
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  • 12
    Electronic Resource
    Electronic Resource
    The caprine MHC contains DYA genes (1993)
    Springer
    Immunogenetics 37 (1993), S. 292-295 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187457
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  • 13
    Electronic Resource
    Electronic Resource
    Interaction of metoprolol with lorazepam and bromazepam (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 405-409 
    Details
    ISSN: 1432-1041
    Keywords: Metoprolol ; lorazepam ; bromazepam ; interaction ; psychomotor tests ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The interaction between metoprolol and bromazepam and lorazepam was studied in 12 healthy male volunteers aged 21–37 years. Metoprolol had no significant effect on the pharmacokinetics of bromazepam or lorazepam. However, bromazepam AUC was 35% higher in the presence of metoprolol. Bromazepam enhanced the effect of metoprolol on systolic blood pressure but not on diastolic blood pressure or pulse rate. Lorazepam had no effect on either blood pressure or pulse. Metoprolol did not enhance the effect of bromazepam on the psychomotor tests used in this study. Metoprolol caused a small increase in critical flicker fusion threshold with lorazepam but had no effect on the other tests. Lorazepam (2 mg) was more potent than bromazepam (6 mg) in the doses used in this study. The interaction of metoprolol with bromazepam and lorazepam is unlikely to be of clinical significance. No change in dose is necessary when using these drugs together.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265852
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  • 14
    Electronic Resource
    Electronic Resource
    Comments on “Nd−Sr isotopic compositions of lower crustal xenoliths-Evidence for the origin of mid-Tertiary felsic volcanics in Mexico” by J. Ruiz, P.J. Patchett, and R.J. Arculus (1990)
    Springer
    Contributions to mineralogy and petrology 104 (1990), S. 609-614 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306668
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  • 15
    Electronic Resource
    Electronic Resource
    Replacement of a conserved glycine residue in subunit II of cytochrome c oxidase interferes with protein function (1994)
    Springer
    Current genetics 25 (1994), S. 233-238 
    Details
    ISSN: 1432-0983
    Keywords: Cytochrome c oxidase ; Respiration deficiency ; Redox center
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In this paper we describe the isolation and characterization of a respiration-deficient yeast strain which is defective in the function of subunit II of cytochrome c oxidase. This strain, VC32, carries a mutation in the mitochondrial COX2 gene which converts a conserved glycine residue to arginine. The conserved glycine is in a region implicated as important for ligating the CuA redox center and for interaction with cytochrome c. We have also characterized five revertants of VC32 which have recovered respiratory function; all five were mapped to the mitochondrial genome. In three of the five revertants the wild-type glycine codon is restored, while in two of the five the mutant arginine codon is still present. These two strains are likely to possess alterations either in components of the mitochondrial translation machinery or in mitochondrially-encoded gene products that interact directly with subunit II to assemble an active oxidase complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00357167
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  • 16
    Electronic Resource
    Electronic Resource
    The effects of ingestion time of gliclazide in relationship to meals on plasma glucose, insulin and c-peptide levels (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 465-467 
    Details
    ISSN: 1432-1041
    Keywords: Gliclazide ; non-insulin dependent diabetes ; administration time ; plasma glucose ; insulin ; c-peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of altering the timing of gliclazide administration in relation to a meal was studied in ten type 2 (non-insulin dependent) chronically treated diabetics. Gliclazide was given 30 min before, at the start of and 30 min after breakfast or omitted altogether. Plasma gliclazide was present at greater than 2 mg/l throughout the study periods. Administration at 30 min after the meal significantly delayed the time to peak for plasma gliclazide. No significant difference was noted in plasma glucose, insulin or c-peptide patterns with any protocol. It is concluded that, in clinical practice, with chronically treated diabetics the timing of gliclazide ingestion in relation to meals is not critical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02336685
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  • 17
    Electronic Resource
    Electronic Resource
    Biochemical and energetic composition of bathyal echinoids and an asteroid, holothuroid and crinoid from the Bahamas (1990)
    Springer
    Marine biology 105 (1990), S. 175-183 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The biochemical and energetic composition of body components of ten species of bathyal echinoids, and an asteroid, a holothuroid and a stalked crinoid were determined from individuals sampled from a variety of deep-water sites near the Bahamas (north Caribbean Sea) in October 1988. When compared with other studies of echinoderms, no geographic- or depth-related differences in biochemical or energetic composition were found. Body-wall tissues were composed primarily of skeletal material (mineral ash), but were comparatively high in organic material in the echinothuriid echinoids, and the asteroid and holothuroid. Gut tissues and pyloric cecae had high levels of lipid and protein, indicating their potential role in nutrient storage. Body-wall tissues were generally low in energy, but were highest in the echinoidsAraeosoma belli (7.7 kJ g−1 dry wt) andSperosoma antillense (8.0 kJ g−1 dry wt), the asteroidOphidiaster alexandri (8.9 kJ g−1 dry wt), and the holothuroidEostichopus regalis (13.1 kJ g−1 dry wt). Energy levels of gut and pyloric cecal tissues were two to three times higher than those of body-wall tissues. Total somatic tissue energy values varied greatly among species, ranging from 1.5 kJ in the echinoidAspidodiadema jacobyi to 142.1 kJ inE. regalis. As the bathyal echinoderms examined in this study occur in great abundance, they represent a significant reservoir of organic and inorganic materials and energy in deep-water benthic systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01344284
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  • 18
    Electronic Resource
    Electronic Resource
    Seasonal breeding aggregations in low-density populations of the bathyal echinoid Stylocidaris lineata (1992)
    Springer
    Marine biology 113 (1992), S. 603-612 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Reproduction of bathyal cidaroid sea urchins was studied between 1985 and 1991 with the aid of a manned submersible in the northern Bahamas. During May 1988 and February 1990, discrete, single-species aggregations of Stylocidaris lineata containing 2 to 6 individuals were observed between 510 and 640 m depths. Reproductive conditions of isolated and aggregated individuals were determined histologically. In February, all individuals, regardless of their spatial distribution, contained developing gametes. During the May spawning season, most isolated individuals contained spent gonads with only relict gametes, whereas individuals in discrete aggregations mostly contained ripe gonads with mature or nearly-mature gametes. Aggregations were not observed during the autumn months, when gonads were spent or immature. These data suggest that bathyal cidaroids aggregate for reproduction. An in situ survey during May indicated that pairs of S. lineata are more common than larger clumps, but no more so than predicted by chance. Homosexual and heterosexual pairs occur at the relative frequencies predicted on the basis of sex ratio. We evaluated the need for reproductive aggregation by applying Denny's (1988) model that predicts downstream sperm concentration in a turbulent boundary layer. Flow parameters were measured with dye injected from the submersible, sperm-release rate was estimated in the laboratory, and the relationship between fertilization success and sperm concentration was determined in a laboratory dilution-experiment. The model predicted that, on smooth sandy bottoms at bathyal depths, sperm concentration should remain high enough to fertilize at least some eggs several meters directly downstream from a spawning male. Aggregation may facilitate spawning synchrony, increase gamete encounter probabilities, or cause gametes to be retained at high concentrations near the adults long enough for fertilization to occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00349704
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  • 19
    Electronic Resource
    Electronic Resource
    Differential termination of primer extension: a novel, quantifiable method for detection of point mutations (1992)
    Springer
    Human genetics 〈Berlin〉 89 (1992), S. 155-157 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have developed a novel technique that is useful for the rapid detection of previously characterized point mutations in the human genome. The method relies on the differential termination of primer extension being performed simultaneously on normal and mutant template molecules in the presence of a selectively limited complement of deoxynucleotide triphosphates. We have used this technique to determine the carrier status of two potential carriers of a hemophilia B mutation at codon 145 in the factor IX gene. In addition, the technique has been used to quantify the levels of mutant sequence in several tissues of a hemophilia B patient who is a somatic mosaic for a point mutation at codon 350.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217115
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  • 20
    Electronic Resource
    Electronic Resource
    Complete set of deuteron analyzing powers in deuteron-proton elastic scattering: Measurement and realistic potential predictions (1993)
    Springer
    Few body systems 15 (1993), S. 67-85 
    Details
    ISSN: 1432-5411
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Tensor analyzing powersiT 11,T 20,T 21 andT 22, have been measured for deuteron laboratory energiesE lab d =75, 85, 95, 106, 119, 131, 144, 156, 172, and 187 MeV. The data are compared to rigorous Faddeev calculations with realistic nucleon-nucleon potentials. A generally good description of the data at all energies is obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01076348
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