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  • Articles  (21)
  • Springer  (15)
  • Wiley  (6)
  • 1990-1994  (16)
  • 1975-1979  (5)
  • Medicine  (21)
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  • Articles  (21)
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  • 1
    Electronic Resource
    Electronic Resource
    Studies on GABA accumulation induced byγ-glutamyl-hydrazide in regions of rat brain following treatment with a tyrosine hydroxylase inhibitor and 6-hydroxy-dopamine (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 945-947 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Reduction of DA receptor activity via depletion of DA stores does not seem to influence GABA turnover in the forebrain and in the DA cell body rich region of the midbrain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951297
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of lead on pregnant women in metropolitan Mexico City (1993)
    Springer
    Bulletin of environmental contamination and toxicology 50 (1993), S. 533-539 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00191242
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  • 3
    Electronic Resource
    Electronic Resource
    Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. I: Concentrations of organo chlorine insecticides, polychlorinated biphenyls, dioxin equivalents, and mercury (1994)
    Springer
    Archives of environmental contamination and toxicology 27 (1994), S. 202-212 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Fishes of the Great Lakes contain hazardous chemicals such as synthetic halogenated hydrocarbons and metals. These fish can move from the lakes into the Great Lakes tributaries of Michigan. In doing so, they transport concentrationsof contaminants which may represent a risk to wildlife. Concentrations of mercury (Hg), total polychlorinated biphenyls (PCBs), 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TCDD-EQ), total DDT complex, aldrin, endrin, dieldrin, heptachlor, heptachlor epoxide, lindane, hexachlorobenzene, cis-chlordane, oxychlordane, endosulfan-I, methoxychlor, trans-chlordane, and trans-nonachlor were determined in composite samples of fishes from above and below Michigan hydroelectric dams, which separate the fishes which have access to the Great Lakes from fishes that do not. Mean concentrations of total PCBs, TCDD-EQ, DDT, and most of the other pesticides were greater in composite samples of six species of fishes from below than above the dams on the Au Sable, Manistee, and Muskegon Rivers. Concentrations of mercury, were the same or greater above the dams than below. However, this difference was statistically significant only on the Au Sable. Mercury concentrations ranged from less than 0.05 mg/kg to 0.73 mg Hg/kg, ww. Total concentrations of PCBs ranged from 0.02 to 1.7 mg/kg, ww. Concentrations of 2,3,7,8-tetrachlordibenzo-p-dioxin equivalents varied among fishes and locations. The concentrations of TCDD-EQ ranged from 2.4 to 71 μg/kg, ww, with concentrations in carp being the greatest. Concentrations of TCDD-EQ were greater than the concentrations which would be expected to occur, due solely to the presence of polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PCDF), and technical mixtures of PCBs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214264
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  • 4
    Electronic Resource
    Electronic Resource
    Seasonal and geographical variation of organochlorine residues in birds from Northwest Mexico (1991)
    Springer
    Archives of environmental contamination and toxicology 21 (1991), S. 541-548 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Eight species of birds (129 individuals) were collected from three agricultural areas with long histories of pesticide use in northwestern Mexico. Plucked carcasses were analyzed for organochlorine (OC) pesticides and polychlorobiphenyls (PCBs). DDE was found in all of the samples and at higher levels than other OCs. Mean (geometric) DDE concentrations varied from 0.04 (μg/g) ppm in mourning doves (Zenaida macroura) to 5.05 ppm in double-crested cormorants (Phalacrocorax auritus). Hexachlorocyclohexane (HCH) was detected in 95% of the samples, but at lower levels than DDE. Hexachlorobenzene (HCB) residues were detected more frequently in birds from Mexicali (62%, p 〈 0.05) than in those from Yaqui and Culiacan. HCH and HCB concentrations were significantly higher in birds from Mexicali during the winter than in the summer (p 〈 0.05), indicating accumulation of these compounds during that period. Other OCs such as DDT, DDD, dieldrin, oxychlordane, heptachlor epoxide, endosulfan, and endrin were found at lower levels and less frequently. PCBs (quantitated as Aroclor® 1260) were found mostly in cattle egrets (Bubulcus ibis) and cormorants at the three locations. Overall, concentrations of OCs were higher for Mexicali than for Yaqui and Culiacan (p 〈 0.01). In a few cases, DDE levels were above those that might adversely affect birds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01183876
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  • 5
    Electronic Resource
    Electronic Resource
    Polychlorinated biphenyls and chlorinated insecticides in plasma of Caspian terns: Relationships with age, productivity, and colony site tenacity in the great lakes (1993)
    Springer
    Archives of environmental contamination and toxicology 24 (1993), S. 320-331 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Chlorinated hydrocarbons such as polychlorinated biphenyls (PCBs) and chlorinated insecticides have often been detected in Great Lakes fish-eating birds at concentrations that are correlated with greater than expected embryo mortality and reduced reproductive success. Blood from 111 known-age, adult Caspian terns (Sterna caspia) nesting in several regions of the upper Great Lakes was collected in 1990 to examine bioavailability of PCBs, to compare concentrations of PCBs among nesting locations, and to determine relationships between concentrations of PCBs and age, productivity, and colony site tenacity. PCBs, DDE, dieldrin, and trans-nonachlor were detected in all the samples. Concentrations of PCBs were, on average, 10, 100, and 250 times greater than those of DDE, dieldrin, and trans-nonachlor, respectively. Concentrations of PCBs were not correlated with age, and were greater in Caspian terns from Saginaw and Green Bays than in Caspian terns from the North Channel and Georgian Bay. Concentrations of PCBs and DDE were significantly correlated with one-another and their accumulation patterns were the most similar among all the chemicals studied. Patterns of organochlorines as determined by cluster analysis were most similar for the nearest nesting locations. The bioaccumulation of PCBs in Great Lakes Caspian terns appeared to be seasonal and did not vary with adult age. A significant negative correlation was observed between mean concentrations of PCBs by region and percent terns returning to natal region. Those populations which were likely to be affected by PCBs were those nesting in Green Bay and Saginaw Bay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01128730
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  • 6
    Electronic Resource
    Electronic Resource
    Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. II: Implications for health of mink (1994)
    Springer
    Archives of environmental contamination and toxicology 27 (1994), S. 213-223 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Populations of mink (Mustela vison) have declined in many areas of the world. Such declines have been linked to exposures to synthetic, halogenated hydrocarbons. In the Great Lakes region, mink are fewer in areas along the shore of the Great Lakes and their tributaries where mink have access to fish from the Great Lakes. Recently, there has been discussion of the relative merits of passage of fishes around hydroelectric dams on rivers in Michigan. A hazard assessment was conducted to determine the potential for adverse effects on mink, which could consume such fishes from above or below dams on the rivers. Concentrations of organochlorine insecticides, polychlorinated biphenyls (PCBs), 2,3,7,8-tetrachloridibenzo-p-dioxin equivalents (TCDD-EQ), and total mercury were measured in composite samples of fishes from above or below hydroelectric dams on the Manistee and Muskegon Rivers, which flow into Lake Michigan, and the Au Sable River, which flows into Lake Huron. Concentrations of organochlorine insecticides, PCBs, and TCDD-EQ were all greater in fishes from below the dams than those from above. Concentrations of neither organochlorine insecticides nor mercury in fishes are currently a risk to mink above or below the dams. All of the species of fishes collected from downstream of the dams contained concentrations of PCBs and TCDD-EQ, which represent a hazard to mink. The hazard index for PCBs was less than one for the average of all species from the upstream reaches of the Manistee and Au Sable Rivers, but not the Muskegon. The hazard index (concentration in fish/NOAEC) was greater than 1 for all of the species collected from below the dams, in all three rivers. The greatest hazard index was observed for carp (Cyprinus carpio) downstream on the Muskegon River. Because the concentrations of PCBs used in the hazard assessment were corrected for relative toxic potencies, the hazard ratios based on PCBs should be similar to those based on TCDD-EQ. This was found to be true. Thus, either total PCBs or TCDD-EQ could be used as the critical toxicant in the hazard assessment. However, if uncorrected concentrations of PCBs, expressed as Aroclors®, were used in the hazard assessment, the toxicity of the weathered mixture would have been underestimated by approximately five-fold, and, in that instance, TCDD-EQ would be the critical contaminant for the hazard assessment. The average maximum allowable percentage of fish from above the dams, which would result in no observable adverse effects of TCDD-EQ, was 70%. Based on the average TCDD-EQ concentrations in the fishes, an average of 8.6% of the diet could be made up of fishes from below dams on the rivers. The most restrictive daily allowable intakes were for carp on the Muskegon and steelhead trout (Onchorhyncus mykiss) on the Manistee Rivers. Only 2.7% of the diet could be made up of these two species from influenced portion of the Au Sable River, they would be exposed to 390 μg PCBs and 8.55 ng of TCDD-EQ per day, respectively (Giesy et al. 1994b). Thus, it would take 15.1 or 77 days for mink to receive their total annual dose of PCBs or TCDD-EQ, respectively. At least for chinook salmon, the critical contaminant for the purposes of hazard assessment would be total concentrations of PCBs. Consuming chinook salmon for as little as 2 weeks would deliver the annual allowable dose of PCBs to mink.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214265
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  • 7
    Electronic Resource
    Electronic Resource
    The liver metabolite S-422 of the hypolipidaemic drug benfluorex decreases cholesterol esterification in fibroblasts and monocyte-like cells (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 339-344 
    Details
    ISSN: 1432-1041
    Keywords: Benfluorex ; cholesterol esterification ; metabolite S-422 ; fibroblasts ; monocyte-like cells ; hepatic metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of S-422 (1-(3-trifluoromethylphenyl)-2-[N-(2-hydroxyethyl) amino] propane), an hepatic metabolite of the hypolipidaemic drug Benfluorex, on lipid metabolism have been investigated in two experimental models: in human fetal lung fibroblasts, for study of the apo B/E receptor-mediated regulation of cholesterol metabolism, and in murine J 774 monocyte-like cells, for study of the scavenger receptor-mediated induction of cholesteryl ester accumulation. In human fibroblasts S-422 increased low density lipoprotein (LDL) catabolism by about 20%, whereas it decreased oleic acid incorporation into triacylglycerols and cholesteryl esters by 25 and 35%, respectively. In J 774 cells, S-422 decreased acetylated LDL degradation and cholesteryl ester formation by about 35%. In both cell types, ACAT activity was significantly reduced by the drug, either after a 24 h pretreatment of the cultured cells, or after an in vitro 30 min preincubation of cell homogenates. The results suggest that S-422, and thus Benfluorex, might prevent the development of atherosclerotic plaques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314964
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  • 8
    Electronic Resource
    Electronic Resource
    Knowledge-based approach to the management of serious arrhythmia in the CCU (1991)
    Springer
    Medical & biological engineering & computing 29 (1991), S. 254-260 
    Details
    ISSN: 1741-0444
    Keywords: Arrhythmia ; Artificial intelligence ; Coronary care unit ; Expert systems ; Intelligent instrumentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract An expert system (SETA) for the management of patients in the CCU environment has been developed. SETA suggests therapeutic actions for the treatment of serious arrhythmias that complicate the pathophysiological state of patients recovering from acute and suspected myocardial infarction. The prototype begins by reasoning from the arrhythmia, diagnosed from the ECG signal, and progresses through its inference process by considering ECG changes (i.e. heart rate, QRS width), patient clinical data, patient history and therapeutic drug data, to reach the most appropriate actions for each particular patient. The system was implemented on production rules using M1 as a development tool. SETA uses a multiknowledge base (KB) architecture, one for each particular arrhythmia and relevant complication, and a decision board that controls the firing of the KBs and keeps track of patient status through time. The system takes into consideration aspects that are very important for the human expert, e.g. sequence of arrhythmia appearance, drug contraindications and priority in the case of simultaneous arrhythmia. The development of this system has given insight into the management of critical CCU patients, that should influence the specification and design of intelligent instruments for this clinical environment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02446707
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  • 9
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    Studies on GABA accumulation induced byγ-glutamyl-hydrazide in regions of rat brain following treatment with a tyrosine hydroxylase inhibitor and 6-hydroxy-dopamine (1977)
    Springer
    Details
    Publication Date: 1977-07-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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  • 10
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    Seasonal and geographical variation of organochlorine residues in birds from Northwest Mexico (1991)
    Springer
    Details
    Publication Date: 1991-11-01
    Print ISSN: 0090-4341
    Electronic ISSN: 1432-0703
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by Springer
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