Publication Date:
1994-11-04
Description:
The function of keratinocyte growth factor (KGF) in normal and wounded skin was assessed by expression of a dominant-negative KGF receptor transgene in basal keratinocytes. The skin of transgenic mice was characterized by epidermal atrophy, abnormalities in the hair follicles, and dermal hyperthickening. Upon skin injury, inhibition of KGF receptor signaling reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in substantially delayed reepithelialization of the wound.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Werner, S -- Smola, H -- Liao, X -- Longaker, M T -- Krieg, T -- Hofschneider, P H -- Williams, L T -- HL-43821/HL/NHLBI NIH HHS/ -- R01 HL32898/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1994 Nov 4;266(5186):819-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cardiovascular Research Institute, University of California at San Francisco (UCSF) 94143-0130.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7973639" target="_blank"〉PubMed〈/a〉
Keywords:
Aging
;
Animals
;
Cell Division
;
Cell Movement
;
Epidermis/pathology
;
Epithelial Cells
;
Fibroblast Growth Factor 10
;
Fibroblast Growth Factor 7
;
*Fibroblast Growth Factors
;
Growth Substances/*physiology
;
Hair/cytology/growth & development
;
Keratinocytes/*cytology/physiology
;
Mice
;
Mice, Transgenic
;
Phenotype
;
Receptor, Fibroblast Growth Factor, Type 2
;
*Receptors, Fibroblast Growth Factor
;
Receptors, Growth Factor/genetics/*physiology
;
Signal Transduction
;
Skin/*cytology
;
Wound Healing/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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