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  • 1
    Electronic Resource
    Electronic Resource
    Bone graft and bone graft substitutes: A review of current technology and applications (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Biomaterials 2 (1991), S. 187-208 
    Details
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The morbidity associated with autogenous bone graft harvest and the recent concern regarding the transmission of live virus through use of allografts, have been the impetus for research into a variety of materials that could take the place of these standard materials for bone grafting. The positive results reported with various ceramics and/or bone derivatives suggest the possibility of a material with osteoconductive and/or osteoinductive properties for use with or in place of bone graft. This review discusses a variety of bone graft and bone graft substitute materials. Among the osteoconductive materials outlined are the hydroxyapatite and tricalcium phosphate ceramics as well as some reportedly osteoactive polymers. While osteoconduction is a favorable quality, much interest has focussed on the use of osteoinductive or osteogenic materials such as demineralized bone matrix or bone derivatives,that is, BMP, osteogenin, etc. It is increasingly apparent that these materials require a carrier vehicle for optimal expression of osteoactivity. Therefore, the review finishes with a comparison of the various materials suggested for use as carriers.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jab.770020307
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  • 2
    Electronic Resource
    Electronic Resource
    Metal ion concentrations in retrieved polyethylene total hip inserts and implications for artifactually high readings in tissue (1993)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 27 (1993), S. 1349-1355 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Although there are many studies which document high metal ion concentrations in clinically retrieved tissues surrounding total joint replacements, most investigations have remained cautious in their interpretation due to the artifactual influences of metal particulate.The possible contribution of polyethylene wear debris to artifactually high periprosthetic metal ion concentration readings has not been previously considered. This study documents the potential role of polyethylene particulate contamination in causing artifactually high metal concentration readings in tissues.The data showed metal ion contamination in the polyethylene was progressive at each stage of exposure to metal: from bar stock preparation, to manufacturing, to in vivo ambulation. The manufacturing and machining processes showed a statistically significant (P ≤ .05) increase in metal ion concentrations in the nonarticulated acetabular inserts over bar stock.The results of this study demonstrate that periprosthetic tissue and synovial fluid metal ion concentration data must be interpreted with caution due to possible artifactual problems associated with metal ion contaminated polyethylene particulate. © 1993 John Wiley & Sons, Inc.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820271102
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  • 3
    Electronic Resource
    Electronic Resource
    Metal ion concentrations in retrieved polyethylene total hip inserts and implications for artifactually high readings in tissue (1994)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 28 (1994), S. 405-405 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820280316
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  • 4
    Electronic Resource
    Electronic Resource
    The peroxidase antiperoxidase staining of factor VIII-related antigen on cultured endothelial cells (1984)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 18 (1984), S. 561-566 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: To prevent the premature occlusion of vascular prostheses, endothelium is being cultured experimentally onto synthetic flow surfaces. A rapid method of identifying cultured endothelium on the prosthesis is valuable for determining the degree of fibroblast and smooth muscle cell contamination and to screen for endothelial cell transformation. Fluorescent Factor VIII related antigen (FVIII-RA) staining has been used to identify cultured endothelium, but results in excessive staining of the underlying prosthesis, loss of morphologic detail, and deterioration of the FVIII-RA antibody reaction with time. We have applied the peroxidase antiperoxidase (PAP) method of antigen staining to permit staining of FVIII-RA and thereby to permit a sensitive and specific identification of human or canine endothelium with a concurrent analysis of morphologic detail.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820180509
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  • 5
    Electronic Resource
    Electronic Resource
    Preliminary characterization of bioresorbable and nonresorbable synthetic fibers for the repair of soft tissue injuries (1990)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 24 (1990), S. 789-808 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Preliminary characterizations of two new synthetic fibers were performed to determine their potentials for use in soft tissue scaffolding devices. A slowly bioresorbing random copolymer of dimethyltrimethylene carbonate (DMTMC) and trimethylene carbonate (TMC) was the first fiber evaluated. The second was a nonresorbable high-strength synthetic fiber of highly oriented polyethylene. Their in vitro mechanical behavior was evaluated by loading fibers in uniaxial tension to determine mechanical properties in dry and wet (saline) environments. The polyethylene fiber had a dry strength of approximately 2.0 GPa, an ultimate strain of 3 to 4%, a tangent modulus of 57 GPa, and was not affected by the saline environment. The bioresorbable fiber had a dry strength of approximately 500 MPa, an ultimate strain of 35%, and tangent modulus of 5.4 GPa. The in vitro resorption of the bioresorbable fibers produced a 15% loss in strength over a 10-week period. In vitro cell-fiber compatibility studies were conducted to assay material biocompatibility and fiber substrate efficacy. Fibroblasts proliferated and migrated on both the polyethylene and bioresorbable fibers at rates similar to those previously found for other compatible fibers, thus demonstrating the new materials to be similar in their in vitro biocompatibility profiles. Morphological assessment with SEM also confirmed that these materials were suitable substrates for cell attachment. A rabbit Achilles tendon repair model using oriented polyethylene or bioresorbable fiber tows was evaluated after 12 and 26 weeks of implantation. The mechanical performances of both types of tendon repairs were similar to those found in previous studies using carbon or PET fibers. The polyethylene fibers elicited a low-grade chronic inflammatory tissue response. The bioresorbable fibers were still intact at 26 weeks and remained relatively inert in the host tissue, eliciting a minimal foreign body response.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820240702
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  • 6
    Electronic Resource
    Electronic Resource
    Investigation of an organic delivery system for demineralized bone matrix in a delayed-healing cranial defect model (1994)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 28 (1994), S. 553-561 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The osteogenic potential of demineralized bone matrix (DBM) has been demonstrated in multiple animal models and clinical applications. A particulate form of DBM is generally used to fill defects because it is easily packed into a defect site without operative planning or shaping. One potential disadvantage in the use of a particulate is the migration of particles from the defect site. To stem this, glycerol was added to DBM to improve handling properties. A study was undertaken to compare two forms of DBM with glycerol, with DBM particulate and autograft in a bony defect site. The model chosen consisted of bilateral 8-mm trephine defects created in the parietal skull of 40 rabbits. Animals were sacrificed at 2 and 8 weeks. Results demonstrated both cartilage and bone induction with the three forms of DBM, with 75-90% of the linear width of the defect filled with new bone by 2 weeks. This was similar to the autograft (86%) and significantly greater than the unfilled defects (26%) at 2 weeks. The addition of glycerol to the DBM did not affect the inductive capacity, and produced a response similar to that of DBM particulate alone or autogenous bone. © 1994 John Wiley & Sons, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820280505
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  • 7
    Electronic Resource
    Electronic Resource
    Measurement of the activation time for platelet adhesion to foreign surfaces (1980)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 14 (1980), S. 417-426 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: An apparatus is described which permitted a perfusant (lactated Ringer's solution) to be passed through a porous sample in a pulsatile manner with a square wave pressure profile. The “on” time, “off” time, number of cycles and pressure amplitude were separately controllable. Using this apparatus and immersing the sample in stirred, heparinized, human blood, there was a certain “off” time below which platelet adhesion to the sample abruptly ceased. The values of this “off” time, termed the activation time ta for platelet adhesion were ∼0.5 sec for 0.2 μm pore size cellulose diacetate/nitrate (millipore filter) and ˜0.3 sec for 0.2 μm polycarbonate (nuclepore filter). After a single cycle with a 5 sec “off” time, adhered platelets on both these materials showed pseudopodia, varying degrees of spreading and membrane perforation.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820140408
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