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  • Other Sources  (28)
  • ASTROPHYSICS  (23)
  • Life Sciences (General)  (5)
  • Astrophysics
  • Polymer and Materials Science
  • 1990-1994  (25)
  • 1980-1984  (3)
  • 1
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    Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication (1992)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We have investigated the direct effect of dimethyl prostaglandin A1 (dmPGA1) on the replication of herpes simplex virus (HSV) and human immunodeficiency virus type 1 (HIV-1). dmPGA1 significantly inhibited viral replication in both HSV and HIV infection systems at concentrations of dmPGA1 that did not adversely alter cellular DNA synthesis. The 50% inhibitory concentration (ID50) for several HSV type 1 (HSV-1) strains ranged from 3.8 to 5.6 micrograms/ml for Vero cells and from 4.6 to 7.3 micrograms/ml for human foreskin fibroblasts. The ID50s for two HSV-2 strains varied from 3.8 to 4.5 micrograms/ml for Vero cells; the ID50 was 5.7 micrograms/ml for human foreskin fibroblasts. We found that closely related prostaglandins did not have the same effect on the replication of HSV; dmPGE2 and dmPGA2 caused up to a 60% increase in HSV replication compared with that in untreated virus-infected cells. HIV-1 replication in acutely infected T cells (VB line) and chronically infected macrophages was assessed by quantitative decreases in p24 concentration. The effective ID50s were 2.5 micrograms/ml for VB cells acutely infected with HIV-1 and 5.2 micrograms/m for chronically infected macrophages. dmPGA1 has an unusual broad-spectrum antiviral activity against both HSV and HIV-1 in vitro and offers a new class of potential therapeutic agents for in vivo use.
    Keywords: Life Sciences (General)
    Type: Antimicrobial agents and chemotherapy (ISSN 0066-4804); Volume 36; 10; 2253-8
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  • 2
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    Review of the biological effects of weightlessness on the human endocrine system (1993)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Studies from space flights over the past two decades have demonstrated that there are basic physiological changes in humans during space flight. These changes include cephalad fluid shifts, loss of fluid and electrolytes, loss of muscle mass, space motion sickness, anemia, reduced immune response, and loss of calcium and mineralized bone. The cause of most of these manifestations is not known but the general approach has been to investigate systemic and hormonal changes. However, data from the 1973-1974 Skylabs, Spacelab 3 (SL-3), Spacelab D-I (SL-DI), and now the new SLS-1 missions support a more basic biological response to microgravity that may occur at the tissue, cellular, and molecular level. This report summarizes ground-based and SLS-1 experiments that examined the mechanism of loss of red blood cell mass in humans, the loss of bone mass and lowered osteoblast growth under space flight conditions, and loss of immune function in microgravity.
    Keywords: Life Sciences (General)
    Type: Receptor (ISSN 1052-8040); Volume 3; 3; 145-54
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  • 3
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    X-ray spectroscopy of SNR E0102-72 with the ASCA satellite (1994)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: The Advanced Satellite for Cosmology and Astrophysics (ASCA) satellite has obtained a moderate-resolution energy spectrum of E0102-72, the brightest Supernova Remnant (SNR) in the Small Magellanic Cloud (SMC). This paper reports on the first results of the analysis of the high quality spectrum of E0102-72. The spectrum shows resolved emission lines of He-like K alpha, H-like K alpha and K beta from oxygen, neon, and magnesium. The intensity ratios of these lines cannot be explained by a multi-component plasma model with uniform abundances, but requires abundance inhomogeneity in the plasma. We demonstrate how the spectral capabilities of the ASCA SIS make available new diagnostics of X-ray plasmas in a state of non-equilibrium ionization. Some interpretation based on the spectral analysis is also given.
    Keywords: ASTROPHYSICS
    Type: PASJ: Publications of the Astronomical Society of Japan (ISSN 0004-6264); 46; 3; p. L121-L124
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  • 4
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    Cytoplasmic pH influences cytoplasmic calcium in MC3T3-E1 osteoblast cells (1993)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: We found that the cytoplasmic concentration of calcium (Cai) of MC3T3-E1 osteoblasts was influenced by the type of pH buffer we used in the perfusing medium, suggesting that intracellular pH (pHi) might influence Cai. To study this effect, the Cai and pHi were monitored as we applied various experimental conditions known to change pHi. Exposure to NH4Cl caused a transient increase in both pHi and Cai without a change in extracellular pH (pHo). Decreasing pHo and pHi by lowering the bicarbonate concentration of the medium decreased Cai, and increasing pHi by the removal of 5% CO2 increased Cai. Clamping pHi to known values with 10 microM nigericin, a potassium proton ionophore, also influenced Cai: acid pHi lowered Cai, whereas alkaline pHi increased it. The rise in Cai appears to be very sensitive to the extracellular concentration of calcium, suggesting the existence of a pH-sensitive calcium influx mechanism. We conclude that physiologic changes in pH could modulate Cai by controlling the influx of calcium ions and could change the time course of the Cai transient associated with hormonal activation.
    Keywords: Life Sciences (General)
    Type: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (ISSN 0884-0431); Volume 8; 6; 725-32
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  • 5
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    Cell cycle arrest by prostaglandin A1 at the G1/S phase interface with up-regulation of oncogenes in S-49 cyc- cells (1994)
    In:  Other Sources
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    Publication Date: 2011-08-24
    Description: Our previous studies have implied that prostaglandins inhibit cell growth independent of cAMP. Recent reports, however, have suggested that prostaglandin arrest of the cell cycle may be mediated through protein kinase A. In this report, in order to eliminate the role of c-AMP in prostaglandin mediated cell cycle arrest, we use the -49 lymphoma variant (cyc-) cells that lack adenylate cyclase activity. We demonstrate that dimethyl prostaglandin A1 (dmPGA1) inhibits DNA synthesis and cell growth in cyc- cells. DNA synthesis is inhibited 42% by dmPGA1 (50 microM) despite the fact that this cell line lacks cellular components needed for cAMP generation. The ability to decrease DNA synthesis depends upon the specific prostaglandin structure with the most effective form possessing the alpha, beta unsaturated ketone ring. Dimethyl PGA1 is most effective in inhibiting DNA synthesis in cyc- cells, with prostaglandins PGE1 and PGB1 being less potent inhibitors of DNA synthesis. DmPGE2 caused a significant stimulation of DNA synthesis. S-49 cyc- variant cells exposed to (30-50 microns) dmPGA1, arrested in the G1 phase of the cell cycle within 24 h. This growth arrest was reversed when the prostaglandin was removed from the cultured cells; growth resumed within hours showing that this treatment is not toxic. The S-49 cyc- cells were chosen not only for their lack of adenylate cyclase activity, but also because their cell cycle has been extensively studied and time requirements for G1, S, G2, and M phases are known. Within hours after prostaglandin removal the cells resume active DNA synthesis, and cell number doubles within 15 h suggesting rapid entry into S-phase DNA synthesis from the G1 cell cycle block.(ABSTRACT TRUNCATED AT 250 WORDS).
    Keywords: Life Sciences (General)
    Type: Journal of cellular biochemistry (ISSN 0730-2312); Volume 54; 3; 265-72
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  • 6
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    The spatial distribution of large cometary meteoroids in the inner solar system (1992)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: A model of the spatial density distribution of large (m greater than 10(exp -3) g) cometary meteoroids in the inner solar system is obtained assuming that they have orbits closely associated with that of their parent comet. Distributions of the orbital parameters of the Taurid, Quadrantid and Perseid meteoroid streams are used in developing the model.
    Keywords: ASTROPHYSICS
    Type: Lunar and Planetary Inst., Asteroids, Comets, Meteors 1991; p 403-406
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  • 7
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    CCD imaging of the inner coma jets of comet P/Halley (1992)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: We analyze the inner coma section of a CCD image of comet P/Halley taken at 1807 UT on 13 March 1986 using a C2 filter (wavelength 5000 to 5200A, half maximum) with the 3.8 m Anglo Australian Telescope at Siding Springs, Australia. Atmospheric turbulence leads to a spreading of the image detail and this produces a blander image of the inner coma region with a slower radial decrease of brightness in comparison to the unaffected image. We remove this smearing by utilizing the point spread function of a star on the same CCD image. Jets were then revealed by removing the average background. Analysis of the jet structure enabled us to estimate the lower limit of the parent molecule velocity. This is found to be 0.3 km s(exp -1).
    Keywords: ASTROPHYSICS
    Type: Lunar and Planetary Inst., Asteroids, Comets, Meteors 1991; p 89-92
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  • 8
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    Midlatitude Pi2 pulsations: AFGL and ISEE magnetometer observations correlated (1982)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: The ISEE observations of the pi2 magnetic pulsations occuring substorm onset in the inner magnetosphere are discussed. One of these events which was also detected as a pi2 event by the AFGL midlatitude magnetometers is considered. The event occurred when the foot of the ISEE field line was over North America. The ground and satellite signals are remarkably similar: they start and stop at the same time, have the same period and can be correlated cycle by cycle. The waves are detected in the electric field data from ISEE 1 and in the magnetic field data from both ISEE 1 and ISEE 2. Calculation of the Poynting vector at ISEE 1 shows that the energy flowed mainly westward, but that there was also a component towards the nearer (southern) ionospheric foot of the field line. The phases between the various field components measured by ISEE 1 and 2 indicate that this is a standing hydromagnetic oscillation.
    Keywords: ASTROPHYSICS
    Type: NASA-TM-84763 , NAS 1.15:84763
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  • 9
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    Interpretation of the number versus diameter distribution for supernova remnants in the Large Magellanic Cloud (1984)
    In:  Other Sources
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    Publication Date: 2019-06-28
    Description: An examination is conducted of the cumulative number versus diameter relation for an X-ray selected sample of supernova remnants in the Large Magellanic Cloud in an attempt to understand the evolutionary state of these objects. Previous studies have suggested that the observed linear N(D) relation requires the remnants in the cloud to be freely expanding. Detailed calculations have been carried out to determine the effect of a luminosity threshold on the observed distribution and it is shown that the observations can be fitted by remnants which are in the adiabatic or later stages of evolution. The implications of the results for the supernova creation rate in the LMC are discussed.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters to the Editor (ISSN 0004-637X); 281; L25-L28
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  • 10
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    Evolution of the ultraviolet coma of comet Austin (1982g.) (1984)
    In:  Other Sources
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    Publication Date: 2019-06-28
    Description: Ultraviolet spectra of comet Austin (1982) obtained in July 1982 at heliocentric distances ranging from 1.10 to 0.81 AU preperihelion with the IUE reveal that the comet is very similar in chemical composition and appearance to comet Bradfield (1979X). In addition, the derived H2O production rate is found to vary with heliocentric distance as r to the -3.6, similar to the r to the -3.7 behavior found for comet Bradfield. It is pointed out, however, that the limited sample rate precludes the observation of the short-term variations which could be produced by a rotating nonuniform cometary nucleus.
    Keywords: ASTROPHYSICS
    Type: Astronomy and Astrophysics (ISSN 0004-6361); 131; 2 Fe
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